Dendritic spine changes associated with normal aging

Dendritic spine changes associated with normal aging

Highlights ► Effects of normal aging on neuronal loss, dendrites, and spines are region-specific. ► In many brain areas, normal aging is accompanied by dendritic regression and spine loss. ► Aging likely affects stubby, mushroom, and thin spines differently. ► Spine changes may contribute to cogniti...

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Bibliographic Details
Published in:Neuroscience Vol. 251; pp. 21 - 32
Main Authors: Dickstein, D.L, Weaver, C.M, Luebke, J.I, Hof, P.R
Format: Journal Article
Language:English
Published: United States Elsevier Ltd 22-10-2013
Subjects:
Aging
Animals
Brain - cytology
Brain - physiology
cognition
Cognition - physiology
dendritic spines
Dendritic Spines - physiology
electrophysiology
Humans
morphology
Neurology
Neuronal Plasticity
Neurons - cytology
Neurons - physiology
hyperpolarization-activated cyclic nucleotide-gated
DG
delayed recognition span test
N-methyl- d-aspartate
prefrontal cortex
ovariectomized
cAMP
PFC
dendritic spines
delayed non-matching-to-sample
DRST
DNMS
OVX
SAMP
ChAT
NMDA
protein kinase C
GluR
morphology
cognition
PKC
postsynaptic currents
dentate gyrus
HCN
senescence-prone strains
choline acetyltransferase
electrophysiology
PSCs
cyclic-AMP
aging
glutamate receptors
N-methyl-d-aspartate
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Description
Summary:Highlights ► Effects of normal aging on neuronal loss, dendrites, and spines are region-specific. ► In many brain areas, normal aging is accompanied by dendritic regression and spine loss. ► Aging likely affects stubby, mushroom, and thin spines differently. ► Spine changes may contribute to cognitive decline, but direct evidence is lacking.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
ISSN:0306-4522
1873-7544
DOI:10.1016/j.neuroscience.2012.09.077