Search Results - "Dickson, T. C."

Anxiolytic- and antidepressant-like properties of ketamine in behavioral and neurophysiological animal models by Engin, E, Treit, D, Dickson, C.T

“…Abstract Ketamine, a dissociative anesthetic agent, appears to have rapid antidepressant effects at sub-anesthetic doses in clinically depressed patients…”
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Epothilone D alters normal growth, viability and microtubule dependent intracellular functions of cortical neurons in vitro by Clark, J. A., Chuckowree, J. A., Dyer, M. S., Dickson, T. C., Blizzard, C. A.

“…Brain penetrant microtubule stabilising agents (MSAs) are being increasingly validated as potential therapeutic strategies for neurodegenerative diseases and…”
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Anxiolytic and antidepressant effects of intracerebroventricularly administered somatostatin: Behavioral and neurophysiological evidence by Engin, E, Stellbrink, J, Treit, D, Dickson, C.T

“…Abstract Somatostatin (SST) is a cyclic polypeptide that inhibits the release of a variety of regulatory hormones (e.g. growth hormone, insulin, glucagon,…”
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The morphological phenotype of β-amyloid plaques and associated neuritic changes in Alzheimer’s disease by Dickson, T.C, Vickers, J.C

“…We have utilised laser confocal microscopy to categorise β-amyloid plaque types that are associated with preclinical and end-stage Alzheimer’s disease and to…”
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Olfactory ensheathing cells promote neurite sprouting of injured axons in vitro by direct cellular contact and secretion of soluble factors by Chung, R S, Woodhouse, A, Fung, S, Dickson, T C, West, A K, Vickers, J C, Chuah, M I

“…Olfactory ensheathing cells (OECs) represent an exciting possibility for promoting axonal regeneration within the injured spinal cord. A number of studies have…”
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Alpha-synuclein is upregulated in neurones in response to chronic oxidative stress and is associated with neuroprotection by Quilty, M.C., King, A.E., Gai, W-P., Pountney, D.L., West, A.K., Vickers, J.C., Dickson, T.C.

“…Chronic oxidative stress has been linked to the neurodegenerative changes characteristic of Parkinson’s disease, particularly alpha-synuclein accumulation and…”
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Neuron–glia interactions underlie ALS-like axonal cytoskeletal pathology by King, A.E, Dickson, T.C, Blizzard, C.A, Woodhouse, A, Foster, S.S, Chung, R.S, Vickers, J.C

“…Abstract Amyotrophic lateral sclerosis (ALS) is a devastating disorder involving loss of movement due to degeneration of motor neurons. Studies suggest that in…”
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Inhibitory synaptic plasticity regulates pyramidal neuron spiking in the rodent hippocampus by Saraga, F, Balena, T, Wolansky, T, Dickson, C.T, Woodin, M.A

“…Abstract Spike-timing modifies the efficacy of both excitatory and inhibitory synapses onto CA1 pyramidal neurons in the rodent hippocampus. Repetitively…”
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The translational inhibitor and amnestic agent emetine also suppresses ongoing hippocampal neural activity similarly to other blockers of protein synthesis by Al‐Smadi, S., Padros, A., Goss, G. G., Dickson, C. T.

“…The consolidation of memory is thought to ultimately depend on the synthesis of new proteins, since translational inhibitors such as anisomycin and…”
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The amnestic agent anisomycin disrupts intrinsic membrane properties of hippocampal neurons via a loss of cellular energetics by Scavuzzo, C J, LeBlancq, M J, Nargang, F, Lemieux, H, Hamilton, T J, Dickson, C T

“…The nearly axiomatic idea that de novo protein synthesis is necessary for long-term memory consolidation is based heavily on behavioral studies using…”
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Electroresponsiveness of medial entorhinal cortex layer III neurons in vitro by Dickson, C.T, Mena, A.R, Alonso, A

“…The entorhinal cortex funnels sensory information from the entire cortical mantle into the hippocampal formation via the perforant path. A major component of…”
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Discharge patterns of hippocampal theta-related cells in the caudal diencephalon of the urethan-anesthetized rat by Bland, B H, Konopacki, J, Kirk, I J, Oddie, S D, Dickson, C T

“…1. Single-unit discharge patterns of cells in specific nuclei of the caudal diencephalon were characterized in relation to simultaneously recorded field…”
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Epothilone D accelerates disease progression in the SOD1G93A mouse model of amyotrophic lateral sclerosis by Clark, J. A., Blizzard, C. A., Breslin, M. C., Yeaman, E. J., Lee, K. M., Chuckowree, J. A., Dickson, T. C.

“…Aims Degeneration of the distal neuromuscular circuitry is a hallmark pathology of Amyotrophic Lateral Sclerosis (ALS). The potential for microtubule…”
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Neurochemical Diversity of Dystrophic Neurites in the Early and Late Stages of Alzheimer's Disease by Dickson, Tracey C., King, Carolyn E., McCormack, Graeme H., Vickers, James C.

“…We examined the neurochemical and morphological diversity of abnormal neurites associated with β-amyloid plaque formation in the early and late stages of…”
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Evidence for Spatial Modules Mediated by Temporal Synchronization of Carbachol-Induced Gamma Rhythm in Medial Entorhinal Cortex by Dickson, Clayton T, Biella, Gerardo, de Curtis, Marco

“…Fast (gamma) oscillations in the cortex underlie the rapid temporal coordination of large-scale neuronal assemblies in the processing of sensory stimuli…”
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Neurofilament triplet proteins are restricted to a subset of neurons in the rat neocortex by Kirkcaldie, M.T.K, Dickson, T.C, King, C.E, Grasby, D, Riederer, B.M, Vickers, J.C

“…The cellular localisation of neurofilament triplet subunits was investigated in the rat neocortex. A subset of mainly pyramidal neurons showed colocalisation…”
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Epothilone D accelerates disease progression in the SOD1 G93A mouse model of amyotrophic lateral sclerosis by Clark, J A, Blizzard, C A, Breslin, M C, Yeaman, E J, Lee, K M, Chuckowree, J A, Dickson, T C

“…Degeneration of the distal neuromuscular circuitry is a hallmark pathology of Amyotrophic Lateral Sclerosis (ALS). The potential for microtubule dysfunction to…”
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Focal damage to the adult rat neocortex induces wound healing accompanied by axonal sprouting and dendritic structural plasticity by Blizzard, Catherine A, Chuckowree, Jyoti A, King, Anna E, Hosie, Katherine A, McCormack, Graeme H, Chapman, Jamie A, Vickers, James C, Dickson, Tracey C

“…Accumulating evidence indicates that damage to the adult mammalian brain evokes an array of adaptive cellular responses and may retain a capacity for…”
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Relationship between apolipoprotein E and the amyloid deposits and dystrophic neurites of Alzheimer's disease by Dickson, T. C., Saunders, H. L., Vickers, J. C.

“…T. C. Dickson, H. L. Saunders and J. C. Vickers (1997) Neuropathology and Applied Neurobiology, 23, 483–491 Relationship between apolipoprotein E and the…”
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Localization of glutamate receptors in developing cortical neurons in culture and relationship to susceptibility to excitotoxicity by King, A.E., Chung, R.S., Vickers, J.C., Dickson, T.C.

“…Overactivation of glutamate receptors leading to excitotoxicity has been implicated in the neurodegenerative alterations of a range of central nervous system…”
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