Search Results - "Dickson, Phillip W."

Tyrosine hydroxylase phosphorylation in vivo by Dunkley, Peter R., Dickson, Phillip W.

“…Tyrosine hydroxylase (TH) is the rate‐limiting enzyme in the synthesis of the catecholamines dopamine, noradrenaline and adrenaline. One of the major…”
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Expression of tyrosine hydroxylase isoforms and phosphorylation at serine 40 in the human nigrostriatal system in Parkinson's disease by Shehadeh, Jacqueline, Double, Kay L., Murphy, Karen E., Bobrovskaya, Larisa, Reyes, Stefanie, Dunkley, Peter R., Halliday, Glenda M., Dickson, Phillip W.

“…Tyrosine hydroxylase is the key enzyme controlling the synthesis of the catecholamines including dopamine. The breakdown of dopamine into toxic compounds has…”
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Tyrosine hydroxylase phosphorylation: regulation and consequences by Dunkley, Peter R., Bobrovskaya, Larisa, Graham, Mark E., Von Nagy‐Felsobuki, Ellak I., Dickson, Phillip W.

“…The rate‐limiting enzyme in catecholamine synthesis is tyrosine hydroxylase. It is phosphorylated at serine (Ser) residues Ser8, Ser19, Ser31 and Ser40 in…”
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Functional programming of the autonomic nervous system by early life immune exposure: implications for anxiety by Sominsky, Luba, Fuller, Erin A, Bondarenko, Evgeny, Ong, Lin Kooi, Averell, Lee, Nalivaiko, Eugene, Dunkley, Peter R, Dickson, Phillip W, Hodgson, Deborah M

“…Neonatal exposure of rodents to an immune challenge alters a variety of behavioural and physiological parameters in adulthood. In particular, neonatal…”
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Reconsidering the role of glial cells in chronic stress-induced dopaminergic neurons loss within the substantia nigra? Friend or foe? by Ong, Lin Kooi, Zhao, Zidan, Kluge, Murielle, TeBay, Clifford, Zalewska, Katarzyna, Dickson, Phillip W, Johnson, Sarah J, Nilsson, Michael, Walker, Frederick R

“…Highlights • Chronic stress triggers loss of dopaminergic neurons within the substantia nigra. • Increased level of oxidative stress. • Suppressed glia…”
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Catalytic domain surface residues mediating catecholamine inhibition in tyrosine hydroxylase by Briggs, Gabrielle D, Bulley, Jesse, Dickson, Phillip W

“…Tyrosine hydroxylase (TH) performs the rate-limiting step in catecholamine (CA) synthesis and is a tetramer composed of regulatory, catalytic and…”
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Mechanism of action of salsolinol on tyrosine hydroxylase by Briggs, Gabrielle D., Nagy, Gyorgy M., Dickson, Phillip W.

“…•Salsolinol binds to the inhibitory dopamine binding sites on tyrosine hydroxylase with low and high affinity.•Salsolinol uses the same inhibitory mechanisms…”
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Tyrosine hydroxylase phosphorylation in catecholaminergic brain regions: a marker of activation following acute hypotension and glucoprivation by Damanhuri, Hanafi A, Burke, Peter G R, Ong, Lin K, Bobrovskaya, Larisa, Dickson, Phillip W, Dunkley, Peter R, Goodchild, Ann K

“…The expression of c-Fos defines brain regions activated by the stressors hypotension and glucoprivation however, whether this identifies all brain sites…”
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Differential Regulation of the Human Tyrosine Hydroxylase Isoforms via Hierarchical Phosphorylation by Lehmann, Ingo T., Bobrovskaya, Larisa, Gordon, Sarah L., Dunkley, Peter R., Dickson, Phillip W.

“…Tyrosine hydroxylase (TH) is the rate-limiting enzyme in the biosynthesis of the catecholamines dopamine, noradrenaline, and adrenaline. In response to short…”
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The Sustained Phase of Tyrosine Hydroxylase Activation In vivo by Ong, Lin Kooi, Sominsky, Luba, Dickson, Phillip W., Hodgson, Deborah M., Dunkley, Peter R.

“…Tyrosine hydroxylase (TH) is the rate-limiting enzyme in the biosynthetic pathway for catecholamine synthesis. Stress triggers an increase in TH activity,…”
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Sustained phosphorylation of tyrosine hydroxylase at serine 40: a novel mechanism for maintenance of catecholamine synthesis by Bobrovskaya, Larisa, Gilligan, Conor, Bolster, Ellen K, Flaherty, Jeffrey J, Dickson, Phillip W, Dunkley, Peter R

“…Tyrosine hydroxylase (TH) is the rate-limiting enzyme in catecholamine synthesis. Its activity is known to be controlled acutely (minutes) by phosphorylation…”
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Tyrosine hydroxylase activity is regulated by two distinct dopamine‐binding sites by Gordon, Sarah L., Quinsey, Noelene S., Dunkley, Peter R., Dickson, Phillip W.

“…Tyrosine hydroxylase (TH), the rate‐limiting enzyme in the biosynthesis of the catecholamines dopamine, noradrenaline and adrenaline, is regulated acutely by…”
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Manganese induces sustained Ser40 phosphorylation and activation of tyrosine hydroxylase in PC12 cells by Posser, Thaís, Franco, Jeferson L, Bobrovskaya, Larisa, Leal, Rodrigo B, Dickson, Phillip W, Dunkley, Peter R

“…Manganese (Mn²⁺) is an essential metal involved in normal functioning of a range of physiological processes. However, occupational overexposure to Mn²⁺ causes…”
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Tyrosine hydroxylase regulation in adult rat striatum following short-term neonatal exposure to manganese by Peres, Tanara V, Ong, Lin K, Costa, Ana Paula, Eyng, Helena, Venske, Débora K R, Colle, Dirleise, Gonçalves, Filipe M, Lopes, Mark W, Farina, Marcelo, Aschner, Michael, Dickson, Phillip W, Dunkley, Peter R, Leal, Rodrigo B

“…Manganese (Mn) is an essential trace element required for a range of physiological processes, but Mn can also be neurotoxic especially during development…”
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PACAP stimulates the sustained phosphorylation of tyrosine hydroxylase at serine 40 by Bobrovskaya, Larisa, Gelain, Daniel P., Gilligan, Conor, Dickson, Phillip W., Dunkley, Peter R.

“…Tyrosine hydroxylase (TH) is the rate-limiting enzyme in catecholamine synthesis. Its activity is controlled by PACAP, acutely by phosphorylation at Ser40 and…”
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Regulation of CaMKII by phospho-Thr253 or phospho-Thr286 sensitive targeting alters cellular function by Skelding, Kathryn A., Suzuki, Tatsuo, Gordon, Sarah, Xue, Jing, Verrills, Nicole M., Dickson, Phillip W., Rostas, John A.P.

“…Calcium/calmodulin-stimulated protein kinase II (CaMKII) is an important mediator of synaptic function that is regulated by multi-site phosphorylation and…”
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Phosphorylation of Ser19 increases both Ser40 phosphorylation and enzyme activity of tyrosine hydroxylase in intact cells by Bobrovskaya, Larisa, Dunkley, Peter R., Dickson, Phillip W.

“…We have previously shown that the phosphorylation of Ser19 in tyrosine hydroxylase can increase the rate of phosphorylation of Ser40 in tyrosine hydroxylase…”
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Phosphorylation of CaMKII at Thr253 occurs in vivo and enhances binding to isolated postsynaptic densities by Migues, Paola V., Lehmann, Ingo T., Fluechter, Lisa, Cammarota, Martin, Gurd, James W., Sim, Alistair T. R., Dickson, Phillip W., Rostas, John A. P.

“…Autophosphorylation of Ca2+‐calmodulin stimulated protein kinase II (CaMKII) at two sites (Thr286 and Thr305/306) is known to regulate the subcellular location…”
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Peripheral inflammation induces long-term changes in tyrosine hydroxylase activation in the substantia nigra by Ong, Lin Kooi, Briggs, Gabrielle D., Guan, Liying, Dunkley, Peter R., Dickson, Phillip W.

“…Inflammation plays a role in neuropathology. We hypothesised that inflammation, induced by a single intraperitoneal injection of lipopolysaccharide (LPS),…”
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Methylmercury neurotoxicity is associated with inhibition of the antioxidant enzyme glutathione peroxidase by Franco, Jeferson L., Posser, Thaís, Dunkley, Peter R., Dickson, Phillip W., Mattos, Jacó J., Martins, Roberta, Bainy, Afonso C.D., Marques, Maria R., Dafre, Alcir L., Farina, Marcelo

“…In this study, we investigated the involvement of glutathione peroxidase—GPx in methylmercury (MeHg)-induced toxicity using three models: (a) in mouse brain…”
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