Search Results - "Dickson, Dorothy M."
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Network analysis of patterns and relevance of enteric pathogen co-infections among infants in a diarrhea-endemic setting
Published in PLoS computational biology (01-11-2023)“…Despite significant progress in recent decades toward ameliorating the excess burden of diarrheal disease globally, childhood diarrhea remains a leading cause…”
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The "Performance of Rotavirus and Oral Polio Vaccines in Developing Countries" (PROVIDE) study: description of methods of an interventional study designed to explore complex biologic problems
Published in The American journal of tropical medicine and hygiene (01-04-2015)“…Oral vaccines appear less effective in children in the developing world. Proposed biologic reasons include concurrent enteric infections, malnutrition, breast…”
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Immunotranscriptomic profiling the acute and clearance phases of a human challenge dengue virus serotype 2 infection model
Published in Nature communications (24-05-2021)“…About 20–25% of dengue virus (DENV) infections become symptomatic ranging from self-limiting fever to shock. Immune gene expression changes during progression…”
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In a randomized trial, the live attenuated tetravalent dengue vaccine TV003 is well-tolerated and highly immunogenic in subjects with flavivirus exposure prior to vaccination
Published in PLoS neglected tropical diseases (08-05-2017)“…Infection caused by the four serotypes of dengue virus (DENV-1-4) is a leading cause of mosquito-borne disease. Clinically-severe dengue disease is more common…”
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Oral rotavirus vaccine shedding as a marker of mucosal immunity
Published in Scientific reports (05-11-2021)“…Group A rotaviruses (RVA) remain a leading cause of pediatric diarrhea worldwide, in part due to underperformance of currently approved live-attenuated, oral…”
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Infant Non-Secretor Histoblood Group Antigen Phenotype Reduces Susceptibility to Both Symptomatic and Asymptomatic Rotavirus Infection
Published in Pathogens (Basel) (01-03-2024)“…The infant non-secretor histoblood group antigen phenotype is associated with reduced risk of symptomatic rotavirus diarrhea, one of the leading global causes…”
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Histo–Blood Group Antigen Phenotype Determines Susceptibility to Genotype-Specific Rotavirus Infections and Impacts Measures of Rotavirus Vaccine Efficacy
Published in The Journal of infectious diseases (11-04-2018)“…Abstract Background Lewis and secretor histo–blood group antigens (HBGAs) have been associated with decreased susceptibility to P[8] genotype rotavirus (RV)…”
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Safety and durable immunogenicity of the TV005 tetravalent dengue vaccine, across serotypes and age groups, in dengue-endemic Bangladesh: a randomised, controlled trial
Published in The Lancet infectious diseases (01-02-2024)“…Morbidity and mortality from dengue virus (DENV) is rapidly growing in the large populations of south Asia. Few formal evaluations of candidate dengue vaccine…”
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TV005 dengue vaccine protects against dengue serotypes 2 and 3 in two controlled human infection studies
Published in The Journal of clinical investigation (01-02-2024)“…BACKGROUNDDisease due to dengue viruses is a growing global health threat, causing 100-400 million cases annually. An ideal dengue vaccine should demonstrate…”
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Maternal Secretor Status Affects Oral Rotavirus Vaccine Response in Breastfed Infants in Bangladesh
Published in The Journal of infectious diseases (13-10-2021)“…Abstract Secretor status controls mucosal histo–blood group antigen expression and is associated with susceptibility to rotavirus (RV) diarrhea, with…”
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Impact of enterovirus and other enteric pathogens on oral polio and rotavirus vaccine performance in Bangladeshi infants
Published in Vaccine (08-06-2016)“…Highlights • Oral vaccines exhibit poor performance in low-income settings. • Enterovirus and Campylobacter carriage are associated with lower OPV…”
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Intradermal fractional-dose inactivated polio vaccine (fIPV) adjuvanted with double mutant Enterotoxigenic Escherichia coli heat labile toxin (dmLT) is well-tolerated and augments a systemic immune response to all three poliovirus serotypes in a randomized placebo-controlled trial
Published in Vaccine (26-04-2022)“…Eradication of poliomyelitis globally is constrained by fecal shedding of live polioviruses, both wild-type and vaccine-derived strains, into the environment…”
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Delayed Dosing of Oral Rotavirus Vaccine Demonstrates Decreased Risk of Rotavirus Gastroenteritis Associated With Serum Zinc: A Randomized Controlled Trial
Published in Clinical infectious diseases (01-09-2016)“…Background. Rotavirus is the world's leading cause of childhood diarrheal death. Despite successes, oral rotavirus vaccines are less effective in developing…”
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Rotavirus-Specific Immunoglobulin A Responses Are Impaired and Serve as a Suboptimal Correlate of Protection Among Infants in Bangladesh
Published in Clinical infectious diseases (02-07-2018)“…Abstract Background Rotavirus (RV)-specific immunoglobulin A (IgA) responses following oral RV vaccination are impaired in low-income countries, where the…”
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Corrigendum to “Intradermal fractional-dose inactivated polio vaccine (fIPV) adjuvanted with double mutant Enterotoxigenic Escherichia coli heat labile toxin (dmLT) is well-tolerated and augments a systemic immune response to all three poliovirus serotypes in a randomized active-controlled trial” [Vaccine 40(19) (2022) 2705–2713]
Published in Vaccine (31-05-2022)Get full text
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The effect of increased inoculum on oral rotavirus vaccine take among infants in Dhaka, Bangladesh: A double-blind, parallel group, randomized, controlled trial
Published in Vaccine (03-01-2020)“…•Oral rotavirus vaccines underperform in low-income countries.•A double vaccine dose did not improve immune response among infants in Bangladesh.•Infants with…”
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Maternal Breast Milk Secretor Phenotype Does Not Affect Infant Susceptibility to Rotavirus Diarrhea
Published in Open forum infectious diseases (01-06-2023)“…Abstract Breast milk secretor status is associated with antibody seroconversion to oral rotavirus vaccination. Here, we were unable to detect a similar impact…”
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Plasma VP8∗-Binding Antibodies in Rotavirus Infection and Oral Vaccination in Young Bangladeshi Children
Published in Journal of the Pediatric Infectious Diseases Society (30-04-2022)“…Abstract Background Despite the availability and success of live-attenuated oral vaccines, rotavirus (RV) remains the leading cause of pediatric…”
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TV005 dengue vaccine protects against dengue serotypes 2 and 3 in two controlled human infection studies
Published in The Journal of clinical investigation (01-02-2024)“…BACKGROUND. Disease dueto dengue viruses is a growing global health threat, causing 100-400 million cases annually. An ideal dengue vaccine should demonstrate…”
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