Search Results - "Dickson, Dennis W"

The neuropathological diagnosis of Alzheimer's disease by DeTure, Michael A, Dickson, Dennis W

“…Alzheimer's disease is a progressive neurodegenerative disease most often associated with memory deficits and cognitive decline, although less common clinical…”
Get full text

Propagation of tau pathology: hypotheses, discoveries, and yet unresolved questions from experimental and human brain studies by Lewis, Jada, Dickson, Dennis W.

“…Tau is a microtubule-associated protein and a key regulator of microtubule stabilization as well as the main component of neurofibrillary tangles—a principle…”
Get full text

Recent advances in neuropathology, biomarkers and therapeutic approach of multiple system atrophy by Koga, Shunsuke, Dickson, Dennis W

“…Multiple system atrophy (MSA) is a progressive neurodegenerative disorder characterised by a variable combination of autonomic failure, levodopa-unresponsive…”
Get full text

Unconventional Translation of C9ORF72 GGGGCC Expansion Generates Insoluble Polypeptides Specific to c9FTD/ALS by Ash, Peter E.A., Bieniek, Kevin F., Gendron, Tania F., Caulfield, Thomas, Lin, Wen-Lang, DeJesus-Hernandez, Mariely, van Blitterswijk, Marka M., Jansen-West, Karen, Paul, Joseph W., Rademakers, Rosa, Boylan, Kevin B., Dickson, Dennis W., Petrucelli, Leonard

“…Frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS) are devastating neurodegenerative disorders with clinical, genetic, and neuropathological…”
Get full text

Neuropathology and molecular diagnosis of Synucleinopathies by Koga, Shunsuke, Sekiya, Hiroaki, Kondru, Naveen, Ross, Owen A, Dickson, Dennis W

“…Synucleinopathies are clinically and pathologically heterogeneous disorders characterized by pathologic aggregates of α-synuclein in neurons and glia, in the…”
Get full text

Posttranslational Modifications Mediate the Structural Diversity of Tauopathy Strains by Arakhamia, Tamta, Lee, Christina E., Carlomagno, Yari, Kumar, Mukesh, Duong, Duc M., Wesseling, Hendrik, Kundinger, Sean R., Wang, Kevin, Williams, Dewight, DeTure, Michael, Dickson, Dennis W., Cook, Casey N., Seyfried, Nicholas T., Petrucelli, Leonard, Steen, Judith A., Fitzpatrick, Anthony W.P.

“…Tau aggregation into insoluble filaments is the defining pathological hallmark of tauopathies. However, it is not known what controls the formation and…”
Get full text

TDP-43 Pathology in Alzheimer's Disease by Meneses, Axel, Koga, Shunsuke, O'Leary, Justin, Dickson, Dennis W, Bu, Guojun, Zhao, Na

“…Transactive response DNA binding protein of 43 kDa (TDP-43) is an intranuclear protein encoded by the TARDBP gene that is involved in RNA splicing,…”
Get full text

Cellular and pathological heterogeneity of primary tauopathies by Chung, Dah-Eun Chloe, Roemer, Shanu, Petrucelli, Leonard, Dickson, Dennis W

“…Microtubule-associated protein tau is abnormally aggregated in neuronal and glial cells in a range of neurodegenerative diseases that are collectively referred…”
Get full text

Limbic-predominant age-related TDP-43 encephalopathy (LATE): consensus working group report by Nelson, Peter T, Dickson, Dennis W, Trojanowski, John Q, Jack, Clifford R, Boyle, Patricia A, Arfanakis, Konstantinos, Rademakers, Rosa, Alafuzoff, Irina, Attems, Johannes, Brayne, Carol, Coyle-Gilchrist, Ian T S, Chui, Helena C, Fardo, David W, Flanagan, Margaret E, Halliday, Glenda, Hokkanen, Suvi R K, Hunter, Sally, Jicha, Gregory A, Katsumata, Yuriko, Kawas, Claudia H, Keene, C Dirk, Kovacs, Gabor G, Kukull, Walter A, Levey, Allan I, Makkinejad, Nazanin, Montine, Thomas J, Murayama, Shigeo, Murray, Melissa E, Nag, Sukriti, Rissman, Robert A, Seeley, William W, Sperling, Reisa A, White, 3rd, Charles L, Yu, Lei, Schneider, Julie A

“…We describe a recently recognized disease entity, limbic-predominant age-related TDP-43 encephalopathy (LATE). LATE neuropathological change (LATE-NC) is…”
Get full text

The ALS disease-associated mutant TDP-43 impairs mitochondrial dynamics and function in motor neurons by Wang, Wenzhang, Li, Li, Lin, Wen-Lang, Dickson, Dennis W, Petrucelli, Leonard, Zhang, Teng, Wang, Xinglong

“…Mutations in TDP-43 lead to familial ALS. Expanding evidence suggests that impaired mitochondrial dynamics likely contribute to the selective degeneration of…”
Get full text

ADAR2 mislocalization and widespread RNA editing aberrations in C9orf72-mediated ALS/FTD by Moore, Stephen, Alsop, Eric, Lorenzini, Ileana, Starr, Alexander, Rabichow, Benjamin E., Mendez, Emily, Levy, Jennifer L., Burciu, Camelia, Reiman, Rebecca, Chew, Jeannie, Belzil, Veronique V., W. Dickson, Dennis, Robertson, Janice, Staats, Kim A., Ichida, Justin K., Petrucelli, Leonard, Van Keuren-Jensen, Kendall, Sattler, Rita

“…The hexanucleotide repeat expansion GGGGCC (G 4 C 2 ) n in the C9orf72 gene is the most common genetic abnormality associated with amyotrophic lateral…”
Get full text

TDP-43 represses cryptic exon inclusion in the FTD–ALS gene UNC13A by Ma, X. Rosa, Prudencio, Mercedes, Koike, Yuka, Vatsavayai, Sarat C., Kim, Garam, Harbinski, Fred, Briner, Adam, Rodriguez, Caitlin M., Guo, Caiwei, Akiyama, Tetsuya, Schmidt, H. Broder, Cummings, Beryl B., Wyatt, David W., Kurylo, Katherine, Miller, Georgiana, Mekhoubad, Shila, Sallee, Nathan, Mekonnen, Gemechu, Ganser, Laura, Rubien, Jack D., Jansen-West, Karen, Cook, Casey N., Pickles, Sarah, Oskarsson, Björn, Graff-Radford, Neill R., Boeve, Bradley F., Knopman, David S., Petersen, Ronald C., Dickson, Dennis W., Shorter, James, Myong, Sua, Green, Eric M., Seeley, William W., Petrucelli, Leonard, Gitler, Aaron D.

“…A hallmark pathological feature of the neurodegenerative diseases amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) is the depletion of…”
Get full text

Neuropathologically defined subtypes of Alzheimer's disease with distinct clinical characteristics: a retrospective study by Murray, Melissa E, PhD, Graff-Radford, Neill R, Prof, Ross, Owen A, PhD, Petersen, Ronald C, Prof, Duara, Ranjan, MD, Dickson, Dennis W, Prof

“…Summary Background Neurofibrillary pathology has a stereotypical progression in Alzheimer's disease (AD) that is encapsulated in the Braak staging scheme;…”
Get full text

Distinct binding of PET ligands PBB3 and AV-1451 to tau fibril strains in neurodegenerative tauopathies by Ono, Maiko, Sahara, Naruhiko, Kumata, Katsushi, Ji, Bin, Ni, Ruiqing, Koga, Shunsuke, Dickson, Dennis W, Trojanowski, John Q, Lee, Virginia M-Y, Yoshida, Mari, Hozumi, Isao, Yoshiyama, Yasumasa, van Swieten, John C, Nordberg, Agneta, Suhara, Tetsuya, Zhang, Ming-Rong, Higuchi, Makoto

“…Diverse neurodegenerative disorders are characterized by deposition of tau fibrils composed of conformers (i.e. strains) unique to each illness. The…”
Get full text

C9orf72 BAC Transgenic Mice Display Typical Pathologic Features of ALS/FTD by O’Rourke, Jacqueline G., Bogdanik, Laurent, Muhammad, A.K.M.G., Gendron, Tania F., Kim, Kevin J., Austin, Andrew, Cady, Janet, Liu, Elaine Y., Zarrow, Jonah, Grant, Sharday, Ho, Ritchie, Bell, Shaughn, Carmona, Sharon, Simpkinson, Megan, Lall, Deepti, Wu, Kathryn, Daughrity, Lillian, Dickson, Dennis W., Harms, Matthew B., Petrucelli, Leonard, Lee, Edward B., Lutz, Cathleen M., Baloh, Robert H.

“…Noncoding expansions of a hexanucleotide repeat (GGGGCC) in the C9orf72 gene are the most common cause of familial amyotrophic lateral sclerosis and…”
Get full text

The first NINDS/NIBIB consensus meeting to define neuropathological criteria for the diagnosis of chronic traumatic encephalopathy by McKee, Ann C., Cairns, Nigel J., Dickson, Dennis W., Folkerth, Rebecca D., Dirk Keene, C., Litvan, Irene, Perl, Daniel P., Stein, Thor D., Vonsattel, Jean-Paul, Stewart, William, Tripodis, Yorghos, Crary, John F., Bieniek, Kevin F., Dams-O’Connor, Kristen, Alvarez, Victor E., Gordon, Wayne A.

“…Chronic traumatic encephalopathy (CTE) is a neurodegeneration characterized by the abnormal accumulation of hyperphosphorylated tau protein within the brain…”
Get full text

AMPK is abnormally activated in tangle- and pre-tangle-bearing neurons in Alzheimer’s disease and other tauopathies by Vingtdeux, Valérie, Davies, Peter, Dickson, Dennis W., Marambaud, Philippe

“…Tauopathies represent a class of neurodegenerative disorders characterized by abnormal tau phosphorylation and aggregation into neuronal paired helical…”
Get full text

Strikingly Different Clinicopathological Phenotypes Determined by Progranulin-Mutation Dosage by Smith, Katherine R., Damiano, John, Franceschetti, Silvana, Carpenter, Stirling, Canafoglia, Laura, Morbin, Michela, Rossi, Giacomina, Pareyson, Davide, Mole, Sara E., Staropoli, John F., Sims, Katherine B., Lewis, Jada, Lin, Wen-Lang, Dickson, Dennis W., Dahl, Hans-Henrik, Bahlo, Melanie, Berkovic, Samuel F.

“…We performed hypothesis-free linkage analysis and exome sequencing in a family with two siblings who had neuronal ceroid lipofuscinosis (NCL). Two linkage…”
Get full text

Structure-based discovery of small molecules that disaggregate Alzheimer’s disease tissue derived tau fibrils in vitro by Seidler, Paul M., Murray, Kevin A., Boyer, David R., Ge, Peng, Sawaya, Michael R., Hu, Carolyn J., Cheng, Xinyi, Abskharon, Romany, Pan, Hope, DeTure, Michael A., Williams, Christopher K., Dickson, Dennis W., Vinters, Harry V., Eisenberg, David S.

“…Alzheimer’s disease (AD) is the consequence of neuronal death and brain atrophy associated with the aggregation of protein tau into fibrils. Thus…”
Get full text

TDP-43 pathology disrupts nuclear pore complexes and nucleocytoplasmic transport in ALS/FTD by Chou, Ching-Chieh, Zhang, Yi, Umoh, Mfon E., Vaughan, Spencer W., Lorenzini, Ileana, Liu, Feilin, Sayegh, Melissa, Donlin-Asp, Paul G., Chen, Yu Han, Duong, Duc M., Seyfried, Nicholas T., Powers, Maureen A., Kukar, Thomas, Hales, Chadwick M., Gearing, Marla, Cairns, Nigel J., Boylan, Kevin B., Dickson, Dennis W., Rademakers, Rosa, Zhang, Yong-Jie, Petrucelli, Leonard, Sattler, Rita, Zarnescu, Daniela C., Glass, Jonathan D., Rossoll, Wilfried

“…The cytoplasmic mislocalization and aggregation of TAR DNA-binding protein-43 (TDP-43) is a common histopathological hallmark of the amyotrophic lateral…”
Get full text