Search Results - "Dickson, Claire"

SHARPER-enhanced benchtop NMR: improving SNR by removing couplings and approaching natural linewidths by Dickson, Claire L, Peat, George, Rossetto, Matheus, Halse, Meghan E, Uhrín, Dušan

“…We present a signal enhancement strategy for benchtop NMR that produces SNR increases on the order of 10 to 30 fold by collapsing the target resonance into an…”
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Sequential ubiquitination and deubiquitination enzymes synchronize the dual sensor and effector functions of TRIM21 by Fletcher, Adam J., Mallery, Donna L., Watkinson, Ruth E., Dickson, Claire F., James, Leo C.

“…Tripartite motif (TRIM) 21 is a cytosolic antibody receptor that neutralizes antibody-coated viruses that penetrate the cell and simultaneously activates…”
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IP6 is an HIV pocket factor that prevents capsid collapse and promotes DNA synthesis by Mallery, Donna L, Márquez, Chantal L, McEwan, William A, Dickson, Claire F, Jacques, David A, Anandapadamanaban, Madhanagopal, Bichel, Katsiaryna, Towers, Gregory J, Saiardi, Adolfo, Böcking, Till, James, Leo C

“…The HIV capsid is semipermeable and covered in electropositive pores that are essential for viral DNA synthesis and infection. Here, we show that these pores…”
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Rapid Estimation of T 1 for Quantitative NMR by Wei, Ran, Dickson, Claire L, Uhrín, Dušan, Lloyd-Jones, Guy C

“…Quantitative NMR spectroscopy (qNMR) is an essential tool in organic chemistry, with applications including reaction monitoring, mechanistic analysis, and…”
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SHARPER-DOSY: Sensitivity enhanced diffusion-ordered NMR spectroscopy by Peat, George, Boaler, Patrick J., Dickson, Claire L., Lloyd-Jones, Guy C., Uhrín, Dušan

“…Since its discovery in mid-20 th century, the sensitivity of Nuclear Magnetic Resonance (NMR) has increased steadily, in part due to the design of new,…”
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Monitoring off-resonance signals with SHARPER NMR - the MR-SHARPER experiment by Davy, Matthew, Dickson, Claire L, Wei, Ran, Uhrín, Dusan, Butts, Craig P

“…We demonstrate an extension to the SHARPER (Sensitive Homogenous and Refocussed Peaks in Real Time) NMR experiment which allows more than one signal to be…”
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A tri-ionic anchor mechanism drives Ube2N-specific recruitment and K63-chain ubiquitination in TRIM ligases by Kiss, Leo, Zeng, Jingwei, Dickson, Claire F., Mallery, Donna L., Yang, Ji-Chun, McLaughlin, Stephen H., Boland, Andreas, Neuhaus, David, James, Leo C.

“…The cytosolic antibody receptor TRIM21 possesses unique ubiquitination activity that drives broad-spectrum anti-pathogen targeting and underpins the protein…”
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Trim-Away ubiquitinates and degrades lysine-less and N-terminally acetylated substrates by Kiss, Leo, Rhinesmith, Tyler, Luptak, Jakub, Dickson, Claire F., Weidenhausen, Jonas, Smyly, Shannon, Yang, Ji-Chun, Maslen, Sarah L., Sinning, Irmgard, Neuhaus, David, Clift, Dean, James, Leo C.

“…TRIM proteins are the largest family of E3 ligases in mammals. They include the intracellular antibody receptor TRIM21, which is responsible for mediating…”
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Target-induced clustering activates Trim-Away of pathogens and proteins by Zeng, Jingwei, Santos, Ana Filipa, Mukadam, Aamir S., Osswald, Mariana, Jacques, David A., Dickson, Claire F., McLaughlin, Stephen H., Johnson, Christopher M., Kiss, Leo, Luptak, Jakub, Renner, Nadine, Vaysburd, Marina, McEwan, William A., Morais-de-Sá, Eurico, Clift, Dean, James, Leo C.

“…Trim-Away is a recently developed technology that exploits off-the-shelf antibodies and the RING E3 ligase and cytosolic antibody receptor TRIM21 to carry out…”
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Hemoglobin variants: biochemical properties and clinical correlates by Thom, Christopher S, Dickson, Claire F, Gell, David A, Weiss, Mitchell J

“…Diseases affecting hemoglobin synthesis and function are extremely common worldwide. More than 1000 naturally occurring human hemoglobin variants with single…”
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IsdB-dependent Hemoglobin Binding Is Required for Acquisition of Heme by Staphylococcus aureus by Pishchany, Gleb, Sheldon, Jessica R., Dickson, Claire F., Alam, Md Tauqeer, Read, Timothy D., Gell, David A., Heinrichs, David E., Skaar, Eric P.

“…Staphylococcus aureus is a Gram-positive pathogen responsible for tremendous morbidity and mortality. As with most bacteria, S. aureus requires iron to cause…”
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Intracellular antibody signalling is regulated by phosphorylation of the Fc receptor TRIM21 by Dickson, Claire, Fletcher, Adam J, Vaysburd, Marina, Yang, Ji-Chun, Mallery, Donna L, Zeng, Jingwei, Johnson, Christopher M, McLaughlin, Stephen H, Skehel, Mark, Maslen, Sarah, Cruickshank, James, Huguenin-Dezot, Nicolas, Chin, Jason W, Neuhaus, David, James, Leo C

“…Cell surface Fc receptors activate inflammation and are tightly controlled to prevent autoimmunity. Antibodies also simulate potent immune signalling from…”
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Rapid HIV‑1 Capsid Interaction Screening Using Fluorescence Fluctuation Spectroscopy by Lau, Derrick, Walsh, James C, Dickson, Claire F, Tuckwell, Andrew, Stear, Jeffrey H, Hunter, Dominic J. B, Bhumkar, Akshay, Shah, Vaibhav, Turville, Stuart G, Sierecki, Emma, Gambin, Yann, Böcking, Till, Jacques, David A

“…The HIV capsid is a multifunctional protein capsule that mediates the delivery of the viral genetic material into the nucleus of the target cell. Host cell…”
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Structure of the Hemoglobin-IsdH Complex Reveals the Molecular Basis of Iron Capture by Staphylococcus aureus by Dickson, Claire F., Kumar, Kaavya Krishna, Jacques, David A., Malmirchegini, G. Reza, Spirig, Thomas, Mackay, Joel P., Clubb, Robert T., Guss, J. Mitchell, Gell, David A.

“…Staphylococcus aureus causes life-threatening disease in humans. The S. aureus surface protein iron-regulated surface determinant H (IsdH) binds to mammalian…”
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The PRE-Derived NMR Model of the 38.8-kDa Tri-Domain IsdH Protein from Staphylococcus aureus Suggests That It Adaptively Recognizes Human Hemoglobin by Sjodt, Megan, Macdonald, Ramsay, Spirig, Thomas, Chan, Albert H., Dickson, Claire F., Fabian, Marian, Olson, John S., Gell, David A., Clubb, Robert T.

“…Staphylococcus aureus is a medically important bacterial pathogen that, during infections, acquires iron from human hemoglobin (Hb). It uses two closely…”
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The Staphylococcus aureus Protein IsdH Inhibits Host Hemoglobin Scavenging to Promote Heme Acquisition by the Pathogen by Sæderup, Kirstine Lindhardt, Stødkilde, Kristian, Graversen, Jonas Heilskov, Dickson, Claire F., Etzerodt, Anders, Hansen, Søren Werner Karlskov, Fago, Angela, Gell, David, Andersen, Christian Brix Folsted, Moestrup, Søren Kragh

“…Hemolysis is a complication in septic infections with Staphylococcus aureus, which utilizes the released Hb as an iron source. S. aureus can acquire heme in…”
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Enhancing 19 F Benchtop NMR Spectroscopy by Combining para -Hydrogen Hyperpolarization and Multiplet Refocusing by Silva Terra, Ana I, Rossetto, Matheus, Dickson, Claire L, Peat, George, Uhrín, Dušan, Halse, Meghan E

“…Benchtop NMR spectrometers provide a promising alternative to high-field NMR for applications that are limited by instrument size and/or cost. F benchtop NMR…”
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Structural Basis for Hemoglobin Capture by Staphylococcus aureus Cell-surface Protein, IsdH by Krishna Kumar, Kaavya, Jacques, David A., Pishchany, Gleb, Caradoc-Davies, Tom, Spirig, Thomas, Malmirchegini, G. Reza, Langley, David B., Dickson, Claire F., Mackay, Joel P., Clubb, Robert T., Skaar, Eric P., Guss, J. Mitchell, Gell, David A.

“…Pathogens must steal iron from their hosts to establish infection. In mammals, hemoglobin (Hb) represents the largest reservoir of iron, and pathogens express…”
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Staphylococcus aureus Uses a Novel Multidomain Receptor to Break Apart Human Hemoglobin and Steal Its Heme by Spirig, Thomas, Malmirchegini, G. Reza, Zhang, Jiang, Robson, Scott A., Sjodt, Megan, Liu, Mengyao, Krishna Kumar, Kaavya, Dickson, Claire F., Gell, David A., Lei, Benfang, Loo, Joseph A., Clubb, Robert T.

“…Staphylococcus aureus is a leading cause of life-threatening infections in the United States. It requires iron to grow, which must be actively procured from…”
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Enhancing 19F Benchtop NMR Spectroscopy by Combining para-Hydrogen Hyperpolarization and Multiplet Refocusing by Silva Terra, Ana I, Rossetto, Matheus, Dickson, Claire L, Peat, George, Uhrín, Dušan, Halse, Meghan E

“…Benchtop NMR spectrometers provide a promising alternative to high-field NMR for applications that are limited by instrument size and/or cost. 19 F benchtop…”
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