Search Results - "Dicks, Ed"

An updated PREDICT breast cancer prognostication and treatment benefit prediction model with independent validation by Candido Dos Reis, Francisco J, Wishart, Gordon C, Dicks, Ed M, Greenberg, David, Rashbass, Jem, Schmidt, Marjanka K, van den Broek, Alexandra J, Ellis, Ian O, Green, Andrew, Rakha, Emad, Maishman, Tom, Eccles, Diana M, Pharoah, Paul D P

“…PREDICT is a breast cancer prognostic and treatment benefit model implemented online. The overall fit of the model has been good in multiple independent case…”
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Population-based targeted sequencing of 54 candidate genes identifies PALB2 as a susceptibility gene for high-grade serous ovarian cancer by Song, Honglin, Dicks, Ed M, Tyrer, Jonathan, Intermaggio, Maria, Chenevix-Trench, Georgia, Bowtell, David D, Traficante, Nadia, Group, Aocs, Brenton, James, Goranova, Teodora, Hosking, Karen, Piskorz, Anna, van Oudenhove, Elke, Doherty, Jen, Harris, Holly R, Rossing, Mary Anne, Duerst, Matthias, Dork, Thilo, Bogdanova, Natalia V, Modugno, Francesmary, Moysich, Kirsten, Odunsi, Kunle, Ness, Roberta, Karlan, Beth Y, Lester, Jenny, Jensen, Allan, Krüger Kjaer, Susanne, Høgdall, Estrid, Campbell, Ian G, Lázaro, Conxi, Pujara, Miguel Angel, Cunningham, Julie, Vierkant, Robert, Winham, Stacey J, Hildebrandt, Michelle, Huff, Chad, Li, Donghui, Wu, Xifeng, Yu, Yao, Permuth, Jennifer B, Levine, Douglas A, Schildkraut, Joellen M, Riggan, Marjorie J, Berchuck, Andrew, Webb, Penelope M, Group, Opal Study, Cybulski, Cezary, Gronwald, Jacek, Jakubowska, Anna, Lubinski, Jan, Alsop, Jennifer, Harrington, Patricia, Chan, Isaac, Menon, Usha, Pearce, Celeste L, Wu, Anna H, de Fazio, Anna, Kennedy, Catherine J, Goode, Ellen, Ramus, Susan, Gayther, Simon, Pharoah, Paul

“…The known epithelial ovarian cancer (EOC) susceptibility genes account for less than 50% of the heritable risk of ovarian cancer suggesting that other…”
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Subclonal phylogenetic structures in cancer revealed by ultra-deep sequencing by Campbell, Peter J, Pleasance, Erin D, Stephens, Philip J, Dicks, Ed, Rance, Richard, Goodhead, Ian, Follows, George A, Green, Anthony R, Futreal, P. Andy, Stratton, Michael R

“…During the clonal expansion of cancer from an ancestral cell with an initiating oncogenic mutation to symptomatic neoplasm, the occurrence of somatic mutations…”
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High throughput DNA sequence variant detection by conformation sensitive capillary electrophoresis and automated peak comparison by Davies, Helen, Dicks, Ed, Stephens, Philip, Cox, Charles, Teague, Jon, Greenman, Chris, Bignell, Graham, O'Meara, Sarah, Edkins, Sarah, Parker, Adrian, Stevens, Claire, Menzies, Andrew, Blow, Matt, Bottomley, Bill, Dronsfield, Mark, Futreal, P. Andrew, Stratton, Michael R., Wooster, Richard

“…We report the development of a heteroduplex-based mutation detection method using multicapillary automated sequencers, known as conformation-sensitive…”
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Mechanisms for pollutant transport between the boundary layer and the free troposphere by Donnell, Elisabeth A., Fish, Deb J., Dicks, Ed M., Thorpe, Alan J.

“…Pollutants are longer‐lived in the free troposphere than the boundary layer, hence the transport of pollutants from the boundary layer to the free troposphere…”
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Long-term trends in the epidemiology of cardiovascular diseases in the UK: insights from the British Heart Foundation statistical compendium by Cheema, Katherine Margaret, Dicks, Ed, Pearson, Jeremy, Samani, Nilesh J

“…Abstract The British Heart Foundation’s (BHF) annual statistical compendium is a comprehensive source of accessible epidemiological data in relation to…”
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Germline Mutations in the BRIP1, BARD1, PALB2, and NBN Genes in Women With Ovarian Cancer by Ramus, Susan J, Song, Honglin, Dicks, Ed, Tyrer, Jonathan P, Rosenthal, Adam N, Intermaggio, Maria P, Fraser, Lindsay, Gentry-Maharaj, Aleksandra, Hayward, Jane, Philpott, Susan, Anderson, Christopher, Edlund, Christopher K, Conti, David, Harrington, Patricia, Barrowdale, Daniel, Bowtell, David D, Alsop, Kathryn, Mitchell, Gillian, Cicek, Mine S, Cunningham, Julie M, Fridley, Brooke L, Alsop, Jennifer, Jimenez-Linan, Mercedes, Poblete, Samantha, Lele, Shashi, Sucheston-Campbell, Lara, Moysich, Kirsten B, Sieh, Weiva, McGuire, Valerie, Lester, Jenny, Bogdanova, Natalia, Dürst, Matthias, Hillemanns, Peter, Odunsi, Kunle, Whittemore, Alice S, Karlan, Beth Y, Dörk, Thilo, Goode, Ellen L, Menon, Usha, Jacobs, Ian J, Antoniou, Antonis C, Pharoah, Paul D P, Gayther, Simon A

“…Epithelial ovarian cancer (EOC) is the most lethal gynecological malignancy, responsible for 13 000 deaths per year in the United States. Risk prediction based…”
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Contribution of Germline Mutations in the RAD51B, RAD51C, and RAD51D Genes to Ovarian Cancer in the Population by Song, Honglin, Dicks, Ed, Ramus, Susan J, Tyrer, Jonathan P, Intermaggio, Maria P, Hayward, Jane, Edlund, Christopher K, Conti, David, Harrington, Patricia, Fraser, Lindsay, Philpott, Susan, Anderson, Christopher, Rosenthal, Adam, Gentry-Maharaj, Aleksandra, Bowtell, David D, Alsop, Kathryn, Cicek, Mine S, Cunningham, Julie M, Fridley, Brooke L, Alsop, Jennifer, Jimenez-Linan, Mercedes, Høgdall, Estrid, Høgdall, Claus K, Jensen, Allan, Kjaer, Susanne Krüger, Lubiński, Jan, Huzarski, Tomasz, Jakubowska, Anna, Gronwald, Jacek, Poblete, Samantha, Lele, Shashi, Sucheston-Campbell, Lara, Moysich, Kirsten B, Odunsi, Kunle, Goode, Ellen L, Menon, Usha, Jacobs, Ian J, Gayther, Simon A, Pharoah, Paul D P

“…The aim of this study was to estimate the contribution of deleterious mutations in the RAD51B, RAD51C, and RAD51D genes to invasive epithelial ovarian cancer…”
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Rare germline genetic variation in PAX8 transcription factor binding sites and susceptibility to epithelial ovarian cancer by Ezquina, Suzana A M, Jones, Michelle, Dicks, Ed, de Vries, Amber, Peng, Pei-Chen, Lawrenson, Kate, Corona, Rosario I, Tyrer, Jonathan, Hazelett, Dennis, Brenton, James, Antoniou, Antonis, Gayther, Simon A, Pharoah, Paul D P

“…Common genetic variation throughout the genome together with rare coding variants identified to date explain about a half of the inherited genetic component of…”
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A risk prediction algorithm for ovarian cancer incorporating BRCA1, BRCA2, common alleles and other familial effects by Jervis, Sarah, Song, Honglin, Lee, Andrew, Dicks, Ed, Harrington, Patricia, Baynes, Caroline, Manchanda, Ranjit, Easton, Douglas F, Jacobs, Ian, Pharoah, Paul P D, Antoniou, Antonis C

“…Although BRCA1 and BRCA2 mutations account for only ∼27% of the familial aggregation of ovarian cancer (OvC), no OvC risk prediction model currently exists…”
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The contribution of deleterious germline mutations in BRCA1, BRCA2 and the mismatch repair genes to ovarian cancer in the population by Song, Honglin, Cicek, Mine S, Dicks, Ed, Harrington, Patricia, Ramus, Susan J, Cunningham, Julie M, Fridley, Brooke L, Tyrer, Jonathan P, Alsop, Jennifer, Jimenez-Linan, Mercedes, Gayther, Simon A, Goode, Ellen L, Pharoah, Paul D P

“…The aim of this study was to estimate the contribution of deleterious mutations in BRCA1, BRCA2, MLH1, MSH2, MSH6 and PMS2 to invasive epithelial ovarian…”
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A genome-wide association scan (GWAS) for mean telomere length within the COGS project: identified loci show little association with hormone-related cancer risk by Pooley, Karen A, Bojesen, Stig E, Weischer, Maren, Nielsen, Sune F, Thompson, Deborah, Amin Al Olama, Ali, Michailidou, Kyriaki, Tyrer, Jonathan P, Benlloch, Sara, Brown, Judith, Audley, Tina, Luben, Robert, Khaw, K-T, Neal, David E, Hamdy, Freddie C, Donovan, Jenny L, Kote-Jarai, Zsofia, Baynes, Caroline, Shah, Mitul, Bolla, Manjeet K, Wang, Qin, Dennis, Joe, Dicks, Ed, Yang, Rongxi, Rudolph, Anja, Schildkraut, Joellen, Chang-Claude, Jenny, Burwinkel, Barbara, Chenevix-Trench, Georgia, Pharoah, Paul D P, Berchuck, Andrew, Eeles, Rosalind A, Easton, Douglas F, Dunning, Alison M, Nordestgaard, Børge G

“…Mean telomere length (TL) in blood cells is heritable and has been reported to be associated with risks of several diseases, including cancer. We conducted a…”
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Acquired mutation of the tyrosine kinase JAK2 in human myeloproliferative disorders by BAXTER, E, SCOTT, L, CAMPBELL, P, EAST, C, FOUROUCLAS, N, SWANTON, S, VASSILIOU, G, BENCH, A, BOYD, E, CURTIN, N

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Ovarian cancer familial relative risks by tumour subtypes and by known ovarian cancer genetic susceptibility variants by Jervis, Sarah, Song, Honglin, Lee, Andrew, Dicks, Ed, Tyrer, Jonathan, Harrington, Patricia, Easton, Douglas F, Jacobs, Ian J, Pharoah, Paul P D, Antoniou, Antonis C

“…Family history is one of the most important risk factors for epithelial ovarian cancer (EOC). Little is known, however, on how EOC familial relative risks…”
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X-linked protocadherin 19 mutations cause female-limited epilepsy and cognitive impairment by Jenkinson, Andrew, Varian, Jennifer, Shoubridge, Cheryl, Vandeleur, Lucianne, Shepherd, Rebecca, Hynes, Kim, Shaw, Marie, Gusella, James F, Teague, John, Edkins, Sarah, Dicks, Ed, Dibbens, Leanne M, Haan, Eric, Gécz, Jozef, Halliday, Kelly, Lerman-Sagie, Tally, Sutton, Edwina, Corbett, Mark, Wray, Paul, Bomar, Jamee, Stevens, Claire, Scheffer, Ingrid E, Barthorpe, Syd, Butler, Adam, Tarpey, Patrick S, Jones, David, Bayly, Marta A, Madison, Mark, West, Sofie, Lev, Dorit, Stratton, Michael R, Neufeld, Miriam Y, Korczyn, Amos D, Tofts, Calli, Futreal, P Andrew, Turner, Samantha J, Kim, Hyung-Goo, Berkovic, Samuel F, Buck, Gemma, O'Meara, Sarah, Friend, Kathryn, Kivity, Sara, Afawi, Zaid, Mironenko, Tatiana, McKee, Shane, Cole, Jennifer, Lee, Rebecca, Geschwind, Daniel H, Widaa, Sara, Ryan, Stephen, Smith, Raffaella, Sutherland, Grant R, Menzies, Andrew, Mulley, John C, Mazarib, Aziz, Derry, Christopher P, Thomas, Paul

“…Epilepsy and mental retardation limited to females (EFMR) is a disorder with an X-linked mode of inheritance and an unusual expression pattern. Disorders…”
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Abstract B37: Germline mutations in new susceptibility genes for non-high-grade serous ovarian cancer by Pavanello, Marina, Dicks, Ed, Song, Honglin, Ariff, Amir, Bolithon, Adelyn, Intermaggio, Maria P., Pinese, Mark, Moysich, Kirsten, Odunsi, Kunle O., Goode, Ellen, Bowtell, David D., Fasching, Peter, Doherty, Jennifer A., Modugno, Francesmary, Kjær, Susanne K., Webb, Penelope M., Wu, Anna, deFazio, Anna, James, Paul, Subramanian, Deepak, Campbell, Ian, Gayther, Simon A., Pharoah, Paul D.P., Ramus, Susan J.

“…Abstract Improving risk prediction and prevention strategies through identifying new susceptibility genes for non-high-grade serous ovarian cancer (non-HGS)…”
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Lung cancer Intragenic ERBB2 kinase mutations in tumours by Futreal, P. Andrew, Stephens, Philip, Hunter, Chris, Bignell, Graham, Edkins, Sarah, Davies, Helen, Teague, Jon, Stevens, Claire, O'Meara, Sarah, Smith, Raffaella, Parker, Adrian, Barthorpe, Andy, Blow, Matthew, Brackenbury, Lisa, Butler, Adam, Clarke, Oliver, Cole, Jennifer, Dicks, Ed, Dike, Angus, Drozd, Anja, Edwards, Ken, Forbes, Simon, Foster, Rebecca, Gray, Kristian, Greenman, Chris, Halliday, Kelly, Hills, Katy, Kosmidou, Vivienne, Lugg, Richard, Menzies, Andy, Perry, Janet, Petty, Robert, Raine, Keiran, Ratford, Lewis, Shepherd, Rebecca, Small, Alexandra, Stephens, Yvonne, Tofts, Calli, Varian, Jennifer, West, Sofie, Widaa, Sara, Yates, Andrew, Brasseur, Francis, Cooper, Colin S, Flanagan, Adrienne M, Knowles, Margaret, Leung, Suet Y, Louis, David N, Looijenga, Leendert H. J, Malkowicz, Bruce, Pierotti, Marco A, Teh, Bin, Chenevix-Trench, Georgia, Weber, Barbara L, Yuen, Siu T, Harris, Grace, Goldstraw, Peter, Nicholson, Andrew G, Wooster, Richard, Stratton, Michael R

“…The protein-kinase family is the most frequently mutated gene family found in human cancer and faulty kinase enzymes are being investigated as promising…”
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Mutation analysis of 24 known cancer genes in the NCI-60 cell line set by Ikediobi, Ogechi N, Davies, Helen, Bignell, Graham, Edkins, Sarah, Stevens, Claire, O'Meara, Sarah, Santarius, Thomas, Avis, Tim, Barthorpe, Syd, Brackenbury, Lisa, Buck, Gemma, Butler, Adam, Clements, Jody, Cole, Jennifer, Dicks, Ed, Forbes, Simon, Gray, Kristian, Halliday, Kelly, Harrison, Rachel, Hills, Katy, Hinton, Jonathan, Hunter, Chris, Jenkinson, Andy, Jones, David, Kosmidou, Vivienne, Lugg, Richard, Menzies, Andrew, Mironenko, Tatiana, Parker, Adrian, Perry, Janet, Raine, Keiran, Richardson, David, Shepherd, Rebecca, Small, Alex, Smith, Raffaella, Solomon, Helen, Stephens, Philip, Teague, Jon, Tofts, Calli, Varian, Jennifer, Webb, Tony, West, Sofie, Widaa, Sara, Yates, Andy, Reinhold, William, Weinstein, John N, Stratton, Michael R, Futreal, P Andrew, Wooster, Richard

“…The panel of 60 human cancer cell lines (the NCI-60) assembled by the National Cancer Institute for anticancer drug discovery is a widely used resource. The…”
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PPM1D Mosaic Truncating Variants in Ovarian Cancer Cases May Be Treatment-Related Somatic Mutations by Pharoah, Paul D P, Song, Honglin, Dicks, Ed, Intermaggio, Maria P, Harrington, Patricia, Baynes, Caroline, Alsop, Kathryn, Bogdanova, Natalia, Cicek, Mine S, Cunningham, Julie M, Fridley, Brooke L, Gentry-Maharaj, Aleksandra, Hillemanns, Peter, Lele, Shashi, Lester, Jenny, McGuire, Valerie, Moysich, Kirsten B, Poblete, Samantha, Sieh, Weiva, Sucheston-Campbell, Lara, Widschwendter, Martin, Whittemore, Alice S, Dörk, Thilo, Menon, Usha, Odunsi, Kunle, Goode, Ellen L, Karlan, Beth Y, Bowtell, David D, Gayther, Simon A, Ramus, Susan J

“…Mosaic truncating mutations in the protein phosphatase, Mg(2+)/Mn(2+)-dependent, 1D (PPM1D) gene have recently been reported with a statistically significantly…”
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Mutations in UPF3B , a member of the nonsense-mediated mRNA decay complex, cause syndromic and nonsyndromic mental retardation by Gécz, Jozef, Perry, Janet, Smith, Raffaella, Edkins, Sarah, Pearson, Pauline, Nguyen, Lam S, Shepherd, Rebecca, West, Sofie, Bobrow, Martin, Teague, John, Sanderson, Tracy, Richardson, David, Wooster, Richard, Varian, Jennifer, Rodriguez, Jayson, Bhat, Shambhu S, Jenkinson, Andrew, Vandeleur, Lucianne, Dicks, Ed, Srivastava, Anand K, Warner, John P, O'Meara, Sarah, Skinner, Cindy, Tarpey, Patrick S, Raine, Keiran, Stevenson, Roger E, Luo, Yin, Barthorpe, Syd, Butler, Adam, Moon, Jenny, Hackett, Anna, Parnau, Josep, Hoganson, George, Thomas, Paul, Hills, Katy, Brooks, Doug, Widaa, Sara, Halliday, Kelly, Lucy Raymond, F, Tofts, Calli, Andrew Futreal, P, Jones, David, Cole, Jennifer, Porteous, Mary E, Menzies, Andrew, Superneau, Duane, Corbett, Mark, Shoubridge, Cheryl, Schwartz, Charles E, Gardner, Alison, Stevens, Claire, Turner, Gillian, Parkinson-Lawrence, Emma, Stratton, Michael R, Buck, Gemma, Mironenko, Tatiana, Simensen, Richard J

“…Nonsense-mediated mRNA decay (NMD) is of universal biological significance. It has emerged as an important global RNA, DNA and translation regulatory pathway…”
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