Search Results - "Dickman, Dion K."

A Presynaptic Glutamate Receptor Subunit Confers Robustness to Neurotransmission and Homeostatic Potentiation by Kiragasi, Beril, Wondolowski, Joyce, Li, Yan, Dickman, Dion K.

“…Homeostatic signaling systems are thought to interface with other forms of plasticity to ensure flexible yet stable levels of neurotransmission. The role of…”
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Endostatin Is a Trans-Synaptic Signal for Homeostatic Synaptic Plasticity by Wang, Tingting, Hauswirth, Anna G., Tong, Amy, Dickman, Dion K., Davis, Graeme W.

“…At synapses in organisms ranging from fly to human, a decrease in postsynaptic neurotransmitter receptor function elicits a homeostatic increase in presynaptic…”
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The Innate Immune Receptor PGRP-LC Controls Presynaptic Homeostatic Plasticity by Harris, Nathan, Braiser, Daniel J., Dickman, Dion K., Fetter, Richard D., Tong, Amy, Davis, Graeme W.

“…It is now appreciated that the brain is immunologically active. Highly conserved innate immune signaling responds to pathogen invasion and injury and promotes…”
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Synapse-specific and compartmentalized expression of presynaptic homeostatic potentiation by Li, Xiling, Goel, Pragya, Chen, Catherine, Angajala, Varun, Chen, Xun, Dickman, Dion K

“…Postsynaptic compartments can be specifically modulated during various forms of synaptic plasticity, but it is unclear whether this precision is shared at…”
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A Hierarchy of Cell Intrinsic and Target-Derived Homeostatic Signaling by Bergquist, Sharon, Dickman, Dion K., Davis, Graeme W.

“…Homeostatic control of neural function can be mediated by the regulation of ion channel expression, neurotransmitter receptor abundance, or modulation of…”
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Activity-dependent facilitation of Synaptojanin and synaptic vesicle recycling by the Minibrain kinase by Chen, Chun-Kan, Bregere, Catherine, Paluch, Jeremy, Lu, Jason F., Dickman, Dion K., Chang, Karen T.

“…Phosphorylation has emerged as a crucial regulatory mechanism in the nervous system to integrate the dynamic signalling required for proper synaptic…”
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Neurodevelopmental disease mechanisms, primary cilia, and endosomes converge on the BLOC‐1 and BORC complexes by Hartwig, Cortnie, Monis, William J., Chen, Xun, Dickman, Dion K., Pazour, Gregory J., Faundez, Victor

“…ABSTRACT The biogenesis of lysosome‐related organelles complex‐1 (BLOC‐1) and the bloc‐one‐related complex (BORC) are the cytosolic protein complexes required…”
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Imaging neuropeptide release at synapses with a genetically engineered reporter by Ding, Keke, Han, Yifu, Seid, Taylor W, Buser, Christopher, Karigo, Tomomi, Zhang, Shishuo, Dickman, Dion K, Anderson, David J

“…Research on neuropeptide function has advanced rapidly, yet there is still no spatio-temporally resolved method to measure the release of neuropeptides in…”
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A Drosophila kinesin required for synaptic bouton formation and synaptic vesicle transport by Kurshan, Peri T, Schwarz, Thomas L, Pack-Chung, Eunju, Dickman, Dion K

“…The morphological transition of growth cones to synaptic boutons characterizes synaptogenesis. Here we have isolated mutations in immaculate connections (imac;…”
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MCTP is an ER-resident calcium sensor that stabilizes synaptic transmission and homeostatic plasticity by Genç, Özgür, Dickman, Dion K, Ma, Wenpei, Tong, Amy, Fetter, Richard D, Davis, Graeme W

“…Presynaptic homeostatic plasticity (PHP) controls synaptic transmission in organisms from to human and is hypothesized to be relevant to the cause of human…”
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A Slowed Classical Pathway Rather Than Kiss-and-Run Mediates Endocytosis at Synapses Lacking Synaptojanin and Endophilin by Dickman, Dion K., Horne, Jane Anne, Meinertzhagen, Ian A., Schwarz, Thomas L.

“…The extent to which a “kiss-and-run” mode of endocytosis contributes to synaptic-vesicle recycling remains controversial. The only genetic evidence for…”
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The BLOC-1 Subunit Pallidin Facilitates Activity-Dependent Synaptic Vesicle Recycling by Chen, Xun, Ma, Wenpei, Zhang, Shixing, Paluch, Jeremy, Guo, Wanlin, Dickman, Dion K

“…Membrane trafficking pathways must be exquisitely coordinated at synaptic terminals to maintain functionality, particularly during conditions of high activity…”
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Extended Synaptotagmin Localizes to Presynaptic ER and Promotes Neurotransmission and Synaptic Growth in Drosophila by Kikuma, Koto, Li, Xiling, Kim, Daniel, Sutter, David, Dickman, Dion K

“…The endoplasmic reticulum (ER) is an extensive organelle in neurons with important roles at synapses including the regulation of cytosolic Ca ,…”
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Schizophrenia Susceptibility Gene dysbindin Controls Synaptic Homeostasis by Dickman, Dion K, Davis, Graeme W

“…The molecular mechanisms that achieve homeostatic stabilization of neural function remain largely unknown. To better understand how neural function is…”
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PIKFYVE inhibition mitigates disease in models of diverse forms of ALS by Hung, Shu-Ting, Linares, Gabriel R., Chang, Wen-Hsuan, Eoh, Yunsun, Krishnan, Gopinath, Mendonca, Stacee, Hong, Sarah, Shi, Yingxiao, Santana, Manuel, Kueth, Chuol, Macklin-Isquierdo, Samantha, Perry, Sarah, Duhaime, Sarah, Maios, Claudia, Chang, Jonathan, Perez, Joscany, Couto, Alexander, Lai, Jesse, Li, Yichen, Alworth, Samuel V., Hendricks, Eric, Wang, Yaoming, Zlokovic, Berislav V., Dickman, Dion K., Parker, J. Alex, Zarnescu, Daniela C., Gao, Fen-Biao, Ichida, Justin K.

“…Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease that results from many diverse genetic causes. Although therapeutics specifically…”
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Gene dosage in the dysbindin schizophrenia susceptibility network differentially affect synaptic function and plasticity by Mullin, Ariana P, Sadanandappa, Madhumala K, Ma, Wenpei, Dickman, Dion K, VijayRaghavan, Krishnaswamy, Ramaswami, Mani, Sanyal, Subhabrata, Faundez, Victor

“…Neurodevelopmental disorders arise from single or multiple gene defects. However, the way multiple loci interact to modify phenotypic outcomes remains poorly…”
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Snapin is critical for presynaptic homeostatic plasticity by Dickman, Dion K, Tong, Amy, Davis, Graeme W

“…The molecular mechanisms underlying the homeostatic modulation of presynaptic neurotransmitter release are largely unknown. We have previously used an…”
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The Proteome of BLOC-1 Genetic Defects Identifies the Arp2/3 Actin Polymerization Complex to Function Downstream of the Schizophrenia Susceptibility Factor Dysbindin at the Synapse by Gokhale, Avanti, Hartwig, Cortnie, Freeman, Amanda H, Das, Ravi, Zlatic, Stephanie A, Vistein, Rachel, Burch, Amelia, Carrot, Guillemette, Lewis, Arielle F, Nelms, Sheldon, Dickman, Dion K, Puthenveedu, Manojkumar A, Cox, Daniel N, Faundez, Victor

“…Proteome modifications downstream of monogenic or polygenic disorders have the potential to uncover novel molecular mechanisms participating in pathogenesis…”
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New approaches for studying synaptic development, function, and plasticity using Drosophila as a model system by Frank, C Andrew, Wang, Xinnan, Collins, Catherine A, Rodal, Avital A, Yuan, Quan, Verstreken, Patrik, Dickman, Dion K

“…The fruit fly Drosophila melanogaster has been established as a premier experimental model system for neuroscience research. These organisms are genetically…”
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Altered Synaptic Development and Active Zone Spacing in Endocytosis Mutants by Dickman, Dion K., Lu, Zhiyuan, Meinertzhagen, Ian A., Schwarz, Thomas L.

“…Many types of synapses have highly characteristic shapes and tightly regulated distributions of active zones, parameters that are important to the function of…”
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