Search Results - "Dickinson, Robin"

Diverse physiological functions for dual-specificity MAP kinase phosphatases by Dickinson, Robin J, Keyse, Stephen M

“…A structurally distinct subfamily of ten dual-specificity (Thr/Tyr) protein phosphatases is responsible for the regulated dephosphorylation and inactivation of…”
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Negative-feedback regulation of FGF signalling by DUSP6/MKP-3 is driven by ERK1/2 and mediated by Ets factor binding to a conserved site within the DUSP6/MKP-3 gene promoter by Ekerot, Maria, Stavridis, Marios P, Delavaine, Laurent, Mitchell, Michael P, Staples, Christopher, Owens, David M, Keenan, Iain D, Dickinson, Robin J, Storey, Kate G, Keyse, Stephen M

“…DUSP6 (dual-specificity phosphatase 6), also known as MKP-3 [MAPK (mitogen-activated protein kinase) phosphatase-3] specifically inactivates ERK1/2…”
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Regulation of Caenorhabditis elegans p53/CEP-1-dependent germ cell apoptosis by Ras/MAPK signaling by Rutkowski, Rachael, Dickinson, Robin, Stewart, Graeme, Craig, Ashley, Schimpl, Marianne, Keyse, Stephen M, Gartner, Anton

“…Maintaining genome stability in the germline is thought to be an evolutionarily ancient role of the p53 family. The sole Caenorhabditis elegans p53 family…”
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DUSP6/MKP-3 inactivates ERK1/2 but fails to bind and inactivate ERK5 by Arkell, Rebecca S., Dickinson, Robin J., Squires, Matthew, Hayat, Shaista, Keyse, Stephen M., Cook, Simon J.

“…Extracellular signal-regulated kinase-1 and -2 (ERK1/2) are activated by dual threonine and tyrosine phosphorylation of a TEY motif. The highly related kinase…”
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Both Nuclear-Cytoplasmic Shuttling of the Dual Specificity Phosphatase MKP-3 and Its Ability to Anchor MAP Kinase in the Cytoplasm Are Mediated by a Conserved Nuclear Export Signal by Karlsson, Maria, Mathers, Joanne, Dickinson, Robin J, Mandl, Margret, Keyse, Stephen M

“…MAP kinase phosphatase (MKP)-3 is a cytoplasmic dual specificity protein phosphatase that specifically binds to and inactivates the ERK1/2 MAP kinases in…”
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Negative Feedback Regulation of FGF Signaling Levels by Pyst1/MKP3 in Chick Embryos by Eblaghie, Maxwell C., Lunn, J.Simon, Dickinson, Robin J., Münsterberg, Andrea E., Sanz-Ezquerro, Juan-Jose, Farrell, Elizabeth R., Mathers, Joanne, Keyse, Stephen M., Storey, Kate, Tickle, Cheryll

“…Background: The importance of endogenous antagonists in intracellular signal transduction pathways is becoming increasingly recognized. There is evidence in…”
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Distinct Docking Mechanisms Mediate Interactions between the Msg5 Phosphatase and Mating or Cell Integrity Mitogen-activated Protein Kinases (MAPKs) in Saccharomyces cerevisiae by Palacios, Lorena, Dickinson, Robin J., Sacristán-Reviriego, Almudena, Didmon, Mark P., Marín, María José, Martín, Humberto, Keyse, Stephen M., Molina, María

“…MAPK phosphatases (MKPs) are negative regulators of signaling pathways with distinct MAPK substrate specificities. For example, the yeast dual specificity…”
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The Dual-Specificity Protein Phosphatase DUSP9/MKP-4 Is Essential for Placental Function but Is Not Required for Normal Embryonic Development by Christie, Graham R., Williams, David J., MacIsaac, Fiona, Dickinson, Robin J., Rosewell, Ian, Keyse, Stephen M.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Phosphorylation of the Kinase Interaction Motif in Mitogen-activated Protein (MAP) Kinase Phosphatase-4 Mediates Cross-talk between Protein Kinase A and MAP Kinase Signaling Pathways by Dickinson, Robin J., Delavaine, Laurent, Cejudo-Marín, Rocío, Stewart, Graeme, Staples, Christopher J., Didmon, Mark P., Trinidad, Antonio Garcia, Alonso, Andrés, Pulido, Rafael, Keyse, Stephen M.

“…MAP kinase phosphatase 4 (DUSP9/MKP-4) plays an essential role during placental development and is one of a subfamily of three closely related cytoplasmic…”
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MKP-3, a Novel Cytosolic Protein-tyrosine Phosphatase That Exemplifies a New Class of Mitogen-activated Protein Kinase Phosphatase (∗) by Muda, Marco, Boschert, Ursula, Dickinson, Robin, Martinou, Jean-Claude, Martinou, Isabelle, Camps, Montserrat, Schlegel, Werner, Arkinstall, Steve

“…MKP-1 (also known as CL100, 3CH134, Erp, and hVH-1) exemplifies a class of dual-specificity phosphatase able to reverse the activation of mitogen-activated…”
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Hippi is essential for node cilia assembly and Sonic hedgehog signaling by Houde, Caroline, Dickinson, Robin J., Houtzager, Vicky M., Cullum, Rebecca, Montpetit, Rachel, Metzler, Martina, Simpson, Elizabeth M., Roy, Sophie, Hayden, Michael R., Hoodless, Pamela A., Nicholson, Donald W.

“…Hippi functions as an adapter protein that mediates pro-apoptotic signaling from poly-glutamine-expanded huntingtin, an established cause of Huntington…”
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Characterization of a murine gene encoding a developmentally regulated cytoplasmic dual-specificity mitogen-activated protein kinase phosphatase by Dickinson, Robin J, Williams, David J, Slack, David N, Williamson, Jill, Seternes, Ole-Morten, Keyse, Stephen M

“…Mitogen-activated protein kinases (MAPKs) play a vital role in cellular growth control, but far less is known about these signalling pathways in the context of…”
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Developmental and plasticity-related differential expression of two SNAP-25 isoforms in the rat brain by Boschert, Ursula, O'Shaughnessy, Celestine, Dickinson, Robin, Tessari, Michela, Bendotti, Caterina, Catsicas, Stefan, Pich, Emilio Merlo

“…In this article we study the relationship between the expression pattern of two recently identified isoforms of the 25‐kD synaptosomal‐associated protein…”
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Expression of the ERK-specific MAP kinase phosphatase PYST1/ MKP3 in mouse embryos during morphogenesis and early organogenesis by Dickinson, Robin J., Eblaghie, Maxwell C., Keyse, Stephen M., Morriss-Kay, Gillian M.

“…Mitogen-activated-protein kinase (MAP kinase) cascades are effector mechanisms for many growth factor signals implicated in developmental processes, including…”
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Regulation of Caenorhabditis elegans p53/CEP-1-Dependent Germ Cell Apoptosis by Ras/MAPK Signaling: e1002238 by Rutkowski, Rachael, Dickinson, Robin, Stewart, Graeme, Craig, Ashley, Schimpl, Marianne, Keyse, Stephen M, Gartner, Anton

“…Maintaining genome stability in the germline is thought to be an evolutionarily ancient role of the p53 family. The sole Caenorhabditis elegans p53 family…”
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Building better health: joint working between health, housing and social care – introduction to the special edition by Glasby, Jon, Dickinson, Helen, Miller, Robin

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Determination of downstream targets of FGF signalling using gene trap and cDNA subtractive approaches by Tateossian, Hilda, Powles, Nicola, Dickinson, Robin, Ficker, Michael, Maconochie, Mark

“…Signalling through the fibroblast growth factor family (FGF) of ligands is essential for normal mammalian embryonic development. At a cellular level, many…”
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Regulated expression of dual specificity protein phosphatases in rat brain by Boschert, Ursula, Dickinson, Robin, Muda, Marco, Camps, Montserrat, Arkinstall, Steve

“…ACTIVATED mitogen-activated protein (MAP) kinases play an essential role controlling many neuronal functions. Dual specificity protein phosphatases (DS-PTPs)…”
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Induction of the dual specificity phosphatase PAC1 in rat brain following seizure activity by Boschert, Ursula, Muda, Marco, Camps, Montserrat, Dickinson, Robin, Arkinstall, Steve

“…RECURRENT seizure activity leads to delayed neuronal death as well as to inflammatory responses involving microglia in hippocampal subfields CA1, CA3 and CA4…”
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A time for birth control by Dickinson, Robin, Pimentel, Jeff

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