Search Results - "Dickinson, Donna A."
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Development and validation of an in vitro micronucleus assay platform in TK6 cells
Published in Mutation research (04-07-2012)“…► TK6 cells are suitable for the MNvit assay in accordance with OECD guideline TG487. ► Extended recovery period after treatment improves sensitivity of TK6…”
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Differentiating mechanisms of toxicity using global gene expression analysis in Saccharomyces cerevisiae
Published in Mutation Research-Fundamental and Molecular Mechanisms of Mutagenesis (04-08-2005)“…Genotoxic stress triggers a variety of biological responses including the transcriptional activation of genes regulating DNA repair, cell survival and cell…”
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Histone markers identify the mode of action for compounds positive in the TK6 micronucleus assay
Published in Mutation research. Genetic toxicology and environmental mutagenesis (01-01-2015)“…•Presents follow-up strategy for in vitro micronucleus positive test results.•Uses histone markers to discriminate aneugens, clastogens and…”
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Evaluation of the Pig-a, micronucleus, and comet assay endpoints in a 28-day study with ethyl methanesulfonate
Published in Environmental and molecular mutagenesis (01-07-2014)“…Ethyl methanesulfonate (EMS) was evaluated as part of the validation effort for the rat Pig‐a mutation assay and compared with other well‐established in vivo…”
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Differentiation of DNA reactive and non-reactive genotoxic mechanisms using gene expression profile analysis
Published in Mutation research (18-05-2004)“…Genotoxic stress triggers a variety of biological responses including the transcriptional activation of genes regulating DNA repair, cell survival and cell…”
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