Chromophore-enhanced laser-tumor tissue photothermal interaction using an 808-nm diode laser

Chromophore-enhanced laser-tumor tissue photothermal interaction using an 808-nm diode laser

A diode laser was used to irradiate tumor tissue, with indocyanine green as the chromophore. The 808-nm wavelength radiation falls within the absorption peak of the chromophore (about 780 nm). The preliminary results in this report revealed clear and significant coupling of this laser and indocyanin...

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Bibliographic Details
Published in:Cancer letters Vol. 88; no. 1; pp. 15 - 19
Main Authors: Chen, Wei R., Adams, Robert L., Heaton, Sean, Dickey, D.Thomas, Bartels, Kenneth E., Nordquist, Robert E.
Format: Journal Article
Language:English
Published: Shannon Elsevier Ireland Ltd 06-01-1995
Elsevier
Subjects:
808-nm Diode laser
Animals
Biological and medical sciences
Cancer treatment
Chromophore
Female
Hot Temperature
In Vitro Techniques
Indocyanine Green
Lasers
Mammary Neoplasms, Experimental - therapy
Medical sciences
Photoradiation therapy and photosensitizing agent
Photosensitizing Agents
Photothermal effect
Rats
Rats, Inbred WF
Treatment with physical agents
Treatment. General aspects
Tumors
Photothermal effect
Indocyanine green
808-nm Diode laser
Cancer treatment
Chromophore
Rat
Treatment efficiency
Rodentia
Laser irradiation
Malignant tumor
Carcinogenesis
In vitro
Isolated organ
Phototherapy
Mammary gland diseases
Pathology
Vertebrata
Experimental disease
Mammalia
Treatment
Animal
Mammary gland
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Summary:A diode laser was used to irradiate tumor tissue, with indocyanine green as the chromophore. The 808-nm wavelength radiation falls within the absorption peak of the chromophore (about 780 nm). The preliminary results in this report revealed clear and significant coupling of this laser and indocyanine green in laser-tissue photothermal interaction. The chromophore targeted tissue showed laser damage while peripheral tissues remained intact. Without the chromophore, this laser inflicted no apparent tissue damage in the non-contact mode with irradiance up to 1755 J/cm 2.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0304-3835
1872-7980
DOI:10.1016/0304-3835(94)03609-M