Search Results - "Dickenson, Anthony H"

Pain and nociception: mechanisms of cancer-induced bone pain by Falk, Sarah, Dickenson, Anthony H

“…Cancer pain, especially pain caused by metastasis to bone, is a severe type of pain, and unless the cause and consequences can be resolved, the pain will…”
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Peripheral input and its importance for central sensitization by Baron, Ralf, Hans, Guy, Dickenson, Anthony H.

“…Many pain states begin with damage to tissue and/or nerves in the periphery, leading to enhanced transmitter release within the spinal cord and central…”
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Modality selective roles of pro-nociceptive spinal 5-HT2A and 5-HT3 receptors in normal and neuropathic states by Patel, Ryan, Dickenson, Anthony H.

“…Descending brainstem control of spinal nociceptive processing permits a dynamic and adaptive modulation of ascending sensory information. Chronic pain states…”
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Combination pharmacotherapy for management of chronic pain: from bench to bedside by Gilron, Ian, Prof, Jensen, Troels S, Prof, Dickenson, Anthony H, Prof

“…Summary Chronic pain, a frequently neglected problem, is treated with different classes of drugs. Current agents are limited by incomplete efficacy and…”
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Osteoarthritis pain: nociceptive or neuropathic? by Thakur, Matthew, Dickenson, Anthony H., Baron, Ralf

“…The most common symptom of osteoarthritis is pain, but current treatments do not identify or treat different types of osteoarthritis-associated pain. In this…”
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Neuronal hyperexcitability in the ventral posterior thalamus of neuropathic rats: modality selective effects of pregabalin by Patel, Ryan, Dickenson, Anthony H

“…Neuropathic pain represents a substantial clinical challenge; understanding the underlying neural mechanisms and back-translation of therapeutics could aid…”
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What goes up must come down: insights from studies on descending controls acting on spinal pain processing by Lockwood, Stevie, Dickenson, Anthony H.

“…Descending controls link higher processing of noxious signals to modulation of spinal cord responses to their noxious inputs. It has become possible to study…”
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Multiple sites and actions of gabapentin-induced relief of ongoing experimental neuropathic pain by Bannister, Kirsty, Qu, Chaoling, Navratilova, Edita, Oyarzo, Janice, Xie, Jennifer Yanhua, King, Tamara, Dickenson, Anthony H., Porreca, Frank

“…Gabapentin (GBP) is a first-line therapy for neuropathic pain, but its mechanisms and sites of action remain uncertain. We investigated GBP-induced modulation…”
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Mechanisms and Management of Diabetic Painful Distal Symmetrical Polyneuropathy by TESFAYE, Solomon, BOULTON, Andrew J. M, DICKENSON, Anthony H

“…Although a number of the diabetic neuropathies may result in painful symptomatology, this review focuses on the most common: chronic sensorimotor distal…”
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Selective modulation of tonic aversive qualities of neuropathic pain by morphine in the central nucleus of the amygdala requires endogenous opioid signaling in the anterior cingulate cortex by Navratilova, Edita, Nation, Kelsey, Remeniuk, Bethany, Neugebauer, Volker, Bannister, Kirsty, Dickenson, Anthony H., Porreca, Frank

“…The amygdala is a key subcortical region believed to contribute to emotional components of pain. As opioid receptors are found in both the central (CeA) and…”
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GPR160 de-orphanization reveals critical roles in neuropathic pain in rodents by Yosten, Gina Lc, Harada, Caron M, Haddock, Chris, Giancotti, Luigino Antonio, Kolar, Grant R, Patel, Ryan, Guo, Chun, Chen, Zhoumou, Zhang, Jinsong, Doyle, Timothy M, Dickenson, Anthony H, Samson, Willis K, Salvemini, Daniela

“…Treating neuropathic pain is challenging and novel non-opioid-based medicines are needed. Using unbiased receptomics, transcriptomic analyses,…”
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Morphine effects within the rodent anterior cingulate cortex and rostral ventromedial medulla reveal separable modulation of affective and sensory qualities of acute or chronic pain by Gomtsian, Lusine, Bannister, Kirsty, Eyde, Nathan, Robles, Dagoberto, Dickenson, Anthony H., Porreca, Frank, Navratilova, Edita

“…Modulation of pain may result from engagement of opioid receptors in multiple brain regions. Whether sensory and affective qualities of pain are differentially…”
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Neural coding of nociceptive stimuli—from rat spinal neurones to human perception by Sikandar, Shafaq, Ronga, Irene, Iannetti, Gian Domenico, Dickenson, Anthony H.

“…This study used radiant laser pulses to explore the central processing and spatial summation of nociceptive inputs in a novel parallel investigation between…”
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Neuropathic pain: Precise sensory profiling improves treatment and calls for back-translation by Baron, Ralf, Dickenson, Anthony H.

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Cell and Molecular Basis of Mechanical, Cold, and Inflammatory Pain by Abrahamsen, Bjarke, Zhao, Jing, Asante, Curtis O, Cendan, Cruz Miguel, Marsh, Steve, Martinez-Barbera, Juan Pedro, Nassar, Mohammed A, Dickenson, Anthony H, Wood, John N

“…Peripheral pain pathways are activated by a range of stimuli. We used diphtheria toxin to kill all mouse postmitotic sensory neurons expressing the sodium…”
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α2δ-1 gene deletion affects somatosensory neuron function and delays mechanical hypersensitivity in response to peripheral nerve damage by Patel, Ryan, Bauer, Claudia S, Nieto-Rostro, Manuela, Margas, Wojciech, Ferron, Laurent, Chaggar, Kanchan, Crews, Kasumi, Ramirez, Juan D, Bennett, David L H, Schwartz, Arnold, Dickenson, Anthony H, Dolphin, Annette C

“…The α2δ-1 subunit of voltage-gated calcium channels is upregulated after sensory nerve injury and is also the therapeutic target of gabapentinoid drugs. It is…”
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Characterisation of a peripheral neuropathic component of the rat monoiodoacetate model of osteoarthritis by Thakur, Matthew, Rahman, Wahida, Hobbs, Carl, Dickenson, Anthony H, Bennett, David L H

“…Joint degeneration observed in the rat monoiodoacetate (MIA) model of osteoarthritis shares many histological features with the clinical condition. The…”
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Translational issues in precision medicine in neuropathic pain by Dickenson, Anthony H., Patel, Ryan

“…Neuropathic pain remains poorly treated, with most new drugs falling through the translational gap. The traditional model of bench-to-bedside research has…”
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Mu-opioid and noradrenergic α2-adrenoceptor contributions to the effects of tapentadol on spinal electrophysiological measures of nociception in nerve-injured rats by Bee, Lucy A., Bannister, Kirsty, Rahman, Wahida, Dickenson, Anthony H.

“…Multiple pathological mechanisms at multiple sensory sites may underlie the pain that follows nerve injury. This provides a basis for recommending more than…”
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Preclinical and Early Clinical Investigations Related to Monoaminergic Pain Modulation by Bannister, Kirsty, Bee, Lucy A., Dickenson, Anthony H.

“…The balance between descending controls, both excitatory and inhibitory, can be altered in various pain states. There is good evidence for a prominent α…”
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