Search Results - "Dick Jr, Lawrence W."

C-terminal lysine variants in fully human monoclonal antibodies: Investigation of test methods and possible causes by Dick, Lawrence W. Jr, Qiu, Difei, Mahon, David, Adamo, Michael, Cheng, Kuang-Chuan

“…The C-terminal lysine variation is commonly observed in biopharmaceutical monoclonal antibodies. This modification can be important since it is found to be…”
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Determination of the origin of the N-terminal pyro-glutamate variation in monoclonal antibodies using model peptides by Dick Jr, Lawrence W., Kim, Catherine, Qiu, Difei, Cheng, Kuang-Chuan

“…The purpose of this work is to determine the cause of the cyclization of the N‐terminal glutamine in recombinant proteins and monoclonal antibodies. This…”
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Isomerization in the CDR2 of a monoclonal antibody: Binding analysis and factors that influence the isomerization rate by Dick Jr, Lawrence W., Qiu, Difei, Wong, Rosie B., Cheng, Kuang-Chuan

“…Isomerization of a monoclonal antibody is one of the common routes of protein degradation. An isomerization in the complementarity‐determining region (CDR) was…”
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Investigation of proteins and peptides from yeastolate and subsequent impurity testing of drug product by Dick Jr, Lawrence W., Kakaley, Jeffrey A., Mahon, David, Qiu, Difei, Cheng, Kuang-Chuan

“…Hydrolysates play an important role in modern biological production. These mixtures are mostly undefined and contain a mixture of proteins, peptides, and amino…”
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Peptide mapping of therapeutic monoclonal antibodies: Improvements for increased speed and fewer artifacts by Dick, Lawrence W., Mahon, David, Qiu, Difei, Cheng, Kuang-Chuan

“…Peptide mapping is a widely utilized technique to characterize monoclonal antibodies for the purpose of product identity and is becoming increasing important…”
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A simple reversed phase high-performance liquid chromatography method for polysorbate 80 quantitation in monoclonal antibody drug products by Adamo, Michael, Dick, Lawrence W., Qiu, Difei, Lee, An-Horng, Devincentis, John, Cheng, Kuang-Chuan

“…In this paper, we discuss an improved high-performance liquid chromatography (HPLC) method for the quantitation of polysorbate 80 (polyoxyethylenesorbitan…”
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Identification and measurement of isoaspartic acid formation in the complementarity determining region of a fully human monoclonal antibody by Dick, Lawrence W., Qiu, Difei, Cheng, Kuang-Chuan

“…Isomerization plays a key role in protein degradation. This isomerization is often difficult to detect by many protein characterization methods such as…”
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Label-free quantitative mass spectrometry for analysis of protein antigens in a meningococcal group B outer membrane vesicle vaccine by Dick Jr, Lawrence W, Mehl, John T, Loughney, John W, Mach, Anna, Rustandi, Richard R, Ha, Sha, Zhang, Lan, Przysiecki, Craig T, Dieter, Lance, Hoang, Van M

“…The development of a multivalent outer membrane vesicle (OMV) vaccine where each strain contributes multiple key protein antigens presents numerous analytical…”
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Evaluation of oligosaccharide methods for carbohydrate analysis in a fully human monoclonal antibody and comparison of the results to the monosaccharide composition determination by a novel calculation by Adamo, Michael, Qiu, Difei, Dick, Lawrence W., Zeng, Ming, Lee, An-Horng, Cheng, Kuang-Chuan

“…Carbohydrates can change a drug's properties including solubility, affinity towards antigen, pharmacokinetics and pharmacodynamics. Due to this importance,…”
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Flow virometry for process monitoring of live virus vaccines-lessons learned from ERVEBO by Ricci, Geoffri, Minsker, Kevin, Kapish, Austin, Osborn, James, Ha, Sha, Davide, Joseph, Califano, Joseph P., Sehlin, Darrell, Rustandi, Richard R., Dick, Lawrence W., Vlasak, Josef, Culp, Timothy D., Baudy, Andreas, Bell, Edward, Mukherjee, Malini

“…Direct at line monitoring of live virus particles in commercial manufacturing of vaccines is challenging due to their small size. Detection of malformed or…”
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Soluble Human Cytomegalovirus gH/gL/pUL128–131 Pentameric Complex, but Not gH/gL, Inhibits Viral Entry to Epithelial Cells and Presents Dominant Native Neutralizing Epitopes by Loughney, John W., Rustandi, Richard R., Wang, Dai, Troutman, Matthew C., Dick, Lawrence W., Li, Guanghua, Liu, Zhong, Li, Fengsheng, Freed, Daniel C., Price, Colleen E., Hoang, Van M., Culp, Timothy D., DePhillips, Pete A., Fu, Tong-Ming, Ha, Sha

“…Congenital infection of human cytomegalovirus (HCMV) is one of the leading causes of nongenetic birth defects, and development of a prophylactic vaccine…”
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Affinity Capture and Detection of Immunoglobulin E in Human Serum Using an Aptamer-Modified Surface in Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry by Cole, Jacquelyn R, Dick, Lawrence W, Morgan, Elizabeth J, McGown, Linda B

“…Capture and detection of immunoglobulin E (IgE) in simple solution and in human serum using an aptamer-modified probe surface for affinity matrix-assisted…”
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Aptamer-Enhanced Laser Desorption/Ionization for Affinity Mass Spectrometry by Dick, Lawrence W, McGown, Linda B

“…The thrombin-binding DNA aptamer was used for affinity capture of thrombin in MALDI-TOF-MS. The aptamer was covalently attached to the surface of a glass slide…”
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Demonstrating β-glucan and yeast peptide clearance in biopharmaceutical downstream processes by Jiang, Canping, Scherfner, Sarah, Shukla, Abhinav A.

“…The use of yeast‐ and plant‐derived hydrolysates in cell culture production processes has sparked concerns over the potential immunogenicity risk posed by…”
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Erratum by Jiang, Canping, Scherfner, Sarah, Dick Jr, Lawrence W., Mahon, David, Qiu, Difei, Cheng, Kuang-Chuan, Shukla, Abhinav A.

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