Search Results - "Dick, Robert D."

A novel role for XIAP in copper homeostasis through regulation of MURR1 by Burstein, Ezra, Ganesh, Lakshmanan, Dick, Robert D, van De Sluis, Bart, Wilkinson, John C, Klomp, Leo WJ, Wijmenga, Cisca, Brewer, George J, Nabel, Gary J, Duckett, Colin S

Get full text

The Role of Copper Suppression as an Antiangiogenic Strategy in Head and Neck Squamous Cell Carcinoma by Cox, Claudell, Teknos, Theodoros N., Barrios, Marty, Brewer, George J., Dick, Robert D., Merajver, Sofia D.

“…Objective To determine whether tetrathiomolybdate (TM), a powerful chelator of copper, is capable of lowering the body stores of copper and suppressing the…”
Get full text

Radiotherapy and Antiangiogenic TM in Lung Cancer by Khan, Mohamed K., Miller, Meredith W., Taylor, Jeremy, Gill, Navkiranjit K., Dick, Robert D., Van Goled, Kenneth, Brewert, George J., Merajver, Sofia D.

“…Tetrathiomolybdate (TM) is a potent nontoxic orally delivered copper complexing agent under development for the last several years for the treatment of…”
Get full text

XIAP Is a Copper Binding Protein Deregulated in Wilson's Disease and Other Copper Toxicosis Disorders by Mufti, Arjmand R., Burstein, Ezra, Csomos, Rebecca A., Graf, Paul C.F., Wilkinson, John C., Dick, Robert D., Challa, Madhavi, Son, Jae-Kyoung, Bratton, Shawn B., Su, Grace L., Brewer, George J., Jakob, Ursula, Duckett, Colin S.

“…X-linked inhibitor of apoptosis (XIAP), known primarily for its caspase inhibitory properties, has recently been shown to interact with and regulate the levels…”
Get full text

Copper deficiency induced by tetrathiomolybdate suppresses tumor growth and angiogenesis by PAN, Quintin, KLEER, Celina G, BREWER, George J, MERAJVER, Sofia D, VAN GOLEN, Kenneth L, IRANI, Jennifer, BOTTEMA, Kristen M, BIAS, Carlos, DE CARVALHO, Magda, MESRI, Enrique A, ROBINS, Diane M, DICK, Robert D

“…Copper plays an essential role in promoting angiogenesis. Tumors that become angiogenic acquire the ability to enter a phase of rapid growth and exhibit…”
Get full text

Treatment of Metastatic Cancer with Tetrathiomolybdate, an Anticopper, Antiangiogenic Agent: Phase I Study by BREWER, G. J, DICK, R. D, STRAWDERMAN, M, LECARPENTIER, G, MERAJVER, S. D, GROVER, D. K, LECLAIRE, V, TSENG, M, WICHA, M, PIENTA, K, REDMAN, B. G, JAHAN, T, SONDAK, V. K

“…Preclinical and in vitro studies have determined that copper is an important cofactor for angiogenesis. Tetrathiomolybdate (TM) was developed as an effective…”
Get full text

Effects of Tetrathiomolybdate in a Mouse Model of Retinal Neovascularization by Elner, Susan G, Elner, Victor M, Yoshida, Ayako, Dick, Robert D, Brewer, George J

“…To determine the effects of tetrathiomolybdate (TM), a copper-chelating agent, on retinal angiogenesis and vascular endothelial growth factor (VEGF) in a mouse…”
Get full text

Treatment of Wilson's disease with zinc: XV long-term follow-up studies by Brewer, George J., Dick, Robert D., Johnson, Virginia D., Brunberg, James A., Kluin, Karen J., Fink, John K.

“…Wilson's disease is an inherited disease of copper accumulation caused by a failure of biliary excretion of excess copper. Accumulated copper causes liver…”
Get full text

Treatment of Wilson disease with ammonium tetrathiomolybdate. II. Initial therapy in 33 neurologically affected patients and follow-up with zinc therapy by Brewer, G J, Johnson, V, Dick, R D, Kluin, K J, Fink, J K, Brunberg, J A

“…To test the efficacy and toxic effects of ammonium tetrathiomolybdate in the initial treatment of a relatively large series of patients with neurologic…”
Get more information

Treatment of Wilson's disease with zinc. XVIII. Initial treatment of the hepatic decompensation presentation with trientine and zinc by Askari, Fred K, Greenson, Joel, Dick, Robert D, Johnson, Virginia D, Brewer, George J

“…We have treated 9 patients who presented with hepatic decompensation resulting from Wilson's disease with a combination of trientine and zinc, generally for at…”
Get full text

A novel role for XIAP in copper homeostasis through regulation of MURR1 by Burstein, Ezra, Ganesh, Lakshmanan, Dick, Robert D, van De Sluis, Bart, Wilkinson, John C, Klomp, Leo WJ, Wijmenga, Cisca, Brewer, George J, Nabel, Gary J, Duckett, Colin S

“…XIAP is a potent suppressor of apoptosis that directly inhibits specific members of the caspase family of cysteine proteases. Here we demonstrate a novel role…”
Get full text

Treatment of Wilson's disease with zinc. XVII: Treatment during pregnancy by Brewer, George J., Johnson, Virginia D., Dick, Robert D., Hedera, Peter, Fink, John K., Kluin, Karen J.

“…Therapy of Wilson's disease continues to evolve. In 1997, zinc acetate was added to the list of drugs approved by the Food and Drug Administration, which…”
Get full text

Inhibition of the Growth of Squamous Cell Carcinoma by Tetrathiomolybdate-Induced Copper Suppression in a Murine Model by Cox, Claudell, Merajver, Sofia D, Yoo, Sirius, Dick, Robert D, Brewer, George J, Lee, Julia Shin-Jung, Teknos, Theodoros N

“…OBJECTIVE To determine whether long-term therapy with tetrathiomolybdate suppresses tumor growth in an animal model. DESIGN In vivo murine model. SUBJECTS…”
Get full text

Treatment of Wilson's disease with zinc XVI: Treatment during the pediatric years by Brewer, George J., Dick, Robert D., Johnson, Virginia D., Fink, John K., Kluin, Karen J., Daniels, Susan

“…The objectives were to evaluate appropriate doses of zinc acetate and its efficacy for the maintenance management of Wilson's disease in pediatric cases…”
Get full text

Treatment of Wilson's disease with ammonium tetrathiomolybdate. I. Initial therapy in 17 neurologically affected patients by Brewer, G J, Dick, R D, Johnson, V, Wang, Y, Yuzbasiyan-Gurkan, V, Kluin, K, Fink, J K, Aisen, A

“…To test the efficacy and toxicity of a new drug, ammonium tetrathiomolybdate, in the initial treatment of a relatively large series of patients presenting with…”
Get more information

Initial therapy of patients with Wilson's disease with tetrathiomolybdate by Brewer, G J, Dick, R D, Yuzbasiyan-Gurkin, V, Tankanow, R, Young, A B, Kluin, K J

“…Patients with Wilson's disease who present with acute neurological symptoms often become clinically worse when initially treated with penicillamine. Other…”
Get more information

Inhibition of the growth of squamous cell carcinoma by tetrathiomolybdate-induced cooper suppression in a murine model by Cox, Claudell, Merajver, Sofia D, Yoo, Sirius, Dick, Robert D

“…OBJECTIVE: To determine whether long-term therapy with tetrathiomolybdate suppresses tumor growth in an animal model. DESIGN: In vivo murine model. SUBJECTS:…”
Get full text

Use of zinc acetate to treat copper toxicosis in dogs by Brewer, G J, Dick, R D, Schall, W, Yuzbasiyan-Gurkan, V, Mullaney, T P, Pace, C, Lindgren, J, Thomas, M, Padgett, G

“…Zinc acetate was used for the treatment and prophylaxis of hepatic copper toxicosis in 3 Bedlington Terriers and 3 West Highland White Terriers. Two dogs of…”
Get more information

Treatment of Wilson's disease with zinc XII: dose regimen requirements by Brewer, G J, Yuzbasiyan-Gurkan, V, Johnson, V, Dick, R D, Wang, Y

“…A considerable body of data is now available indicating the efficacy and lack of toxicity of zinc treatment of Wilson's disease. Dose-response studies have…”
Get more information

Correction of cerebrospinal fluid copper in Menkes kinky hair disease by Kollros, P R, Dick, R D, Brewer, G J

“…A patient with Menkes Kinky Hair disease was treated with infusions of copper-histidine which resulted in normal copper values in the cerebrospinal fluid. This…”
Get more information