Search Results - "Dick, Robert"
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Plastic anisotropy and failure in thin metal: Material characterization and fracture prediction with an advanced constitutive model and polar EPS (effective plastic strain) fracture diagram for AA 3014-H19
Published in International journal of solids and structures (15-10-2018)“…Material characterizations for plasticity and fracture have been conducted from uniaxial tensile tests, bi-axial bulge test, and disk compression test for a…”
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Permeability of the HIV-1 capsid to metabolites modulates viral DNA synthesis
Published in PLoS biology (17-12-2020)“…Reverse transcription, an essential event in the HIV-1 life cycle, requires deoxynucleotide triphosphates (dNTPs) to fuel DNA synthesis, thus requiring…”
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Primate lentiviruses require Inositol hexakisphosphate (IP6) or inositol pentakisphosphate (IP5) for the production of viral particles
Published in PLoS pathogens (01-08-2020)“…Inositol hexakisphosphate (IP6) potently stimulates HIV-1 particle assembly in vitro and infectious particle production in vivo. However, knockout cells…”
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Evidence of Health Risks Associated with Prolonged Standing at Work and Intervention Effectiveness
Published in Rehabilitation nursing (01-05-2015)“…Purpose Prolonged standing at work has been shown to be associated with a number of potentially serious health outcomes, such as lower back and leg pain,…”
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Inositol phosphates are assembly co-factors for HIV-1
Published in Nature (London) (01-08-2018)“…A short, 14-amino-acid segment called SP1, located in the Gag structural protein 1 , has a critical role during the formation of the HIV-1 virus particle…”
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Structures of immature EIAV Gag lattices reveal a conserved role for IP6 in lentivirus assembly
Published in PLoS pathogens (01-01-2020)“…Retrovirus assembly is driven by the multidomain structural protein Gag. Interactions between the capsid domains (CA) of Gag result in Gag multimerization,…”
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Mechanisms of PI(4,5)P2 Enrichment in HIV-1 Viral Membranes
Published in Journal of molecular biology (04-09-2020)“…Phosphatidylinositol 4,5-bisphosphate (PIP2) is critical for HIV-1 virus assembly. The viral membrane is enriched in PIP2, suggesting that the virus assembles…”
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Online Resource Management for Improving Reliability of Real-Time Systems on "Big-Little" Type MPSoCs
Published in IEEE transactions on computer-aided design of integrated circuits and systems (01-01-2020)“…Heterogeneous multiprocessor systems on a chips (MPSoCs) consisting of cores with different performance/power characteristics are widely used in many real-time…”
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IP6 Regulation of HIV Capsid Assembly, Stability, and Uncoating
Published in Viruses (15-11-2018)“…The mechanisms that drive formation of the HIV capsid, first as an immature particle and then as a mature protein shell, remain incompletely understood. Recent…”
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Subnanometer Structure of an Asymmetric Model Membrane: Interleaflet Coupling Influences Domain Properties
Published in Langmuir (24-05-2016)“…Cell membranes possess a complex three-dimensional architecture, including nonrandom lipid lateral organization within the plane of a bilayer leaflet, and…”
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Improving System-Level Lifetime Reliability of Multicore Soft Real-Time Systems
Published in IEEE transactions on very large scale integration (VLSI) systems (01-06-2017)“…This paper studies the problem of maximizing multicore system lifetime reliability, an important design consideration for many real-time embedded systems…”
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Structural insights into HIV-1 polyanion-dependent capsid lattice formation revealed by single particle cryo-EM
Published in Proceedings of the National Academy of Sciences - PNAS (02-05-2023)“…The HIV-1 capsid houses the viral genome and interacts extensively with host cell proteins throughout the viral life cycle. It is composed of capsid protein…”
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Biochemical Reconstitution of HIV-1 Assembly and Maturation
Published in Journal of virology (14-02-2020)“…The assembly of an orthoretrovirus such as HIV-1 requires the coordinated functioning of multiple biochemical activities of the viral Gag protein. These…”
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Distinct stabilization of the human T cell leukemia virus type 1 immature Gag lattice
Published in Nature structural & molecular biology (06-09-2024)“…Human T cell leukemia virus type 1 (HTLV-1) immature particles differ in morphology from other retroviruses, suggesting a distinct way of assembly. Here we…”
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Improving Reliability of Soft Real-Time Embedded Systems on Integrated CPU and GPU Platforms
Published in IEEE transactions on computer-aided design of integrated circuits and systems (01-10-2020)“…Multiprocessor systems on a chip consisting of integrated CPUs and GPUs are suitable platforms for real-time embedded applications requiring massively parallel…”
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HIV-1 Gag protein can sense the cholesterol and acyl chain environment in model membranes
Published in Proceedings of the National Academy of Sciences - PNAS (13-11-2012)“…Membrane binding of the HIV-1 group-specific antigen (Gag) structural protein, a critical step in viral assembly at the plasma membrane, is mediated by the…”
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Spatial-Frequency Network for Segmentation of Remote Sensing Images
Published in 2023 IEEE International Conference on Image Processing (ICIP) (08-10-2023)“…We describe a deep learning system for satellite image segmentation. Our CNN model embeds contextual feature dependencies in both spatial and frequency…”
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Conference Proceeding -
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Digital Foveation: An Energy-Aware Machine Vision Framework
Published in IEEE transactions on computer-aided design of integrated circuits and systems (01-11-2018)“…In machine vision applications, imaging systems and analysis algorithms are generally interdependent and energy intensive. We describe a machine vision energy…”
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A Structural Perspective of the Role of IP6 in Immature and Mature Retroviral Assembly
Published in Viruses (17-09-2021)“…The small cellular molecule inositol hexakisphosphate (IP6) has been known for ~20 years to promote the in vitro assembly of HIV-1 into immature virus-like…”
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Exploring high-resolution cryo-ET and subtomogram averaging capabilities of contemporary DEDs
Published in Journal of structural biology (01-06-2022)“…[Display omitted] •We demonstrate the capabilities of two cryo-EM systems equipped with contemporary direct-electron detectors and energy filters for…”
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