Search Results - "Dicarlo, E"

RNA-Guided Human Genome Engineering via Cas9 by Mali, Prashant, Yang, Luhan, Esvelt, Kevin M., Aach, John, Guell, Marc, DiCarlo, James E., Norville, Julie E., Church, George M.

“…Bacteria and archaea have evolved adaptive immune defenses, termed clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated (Cas)…”
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Design of a synthetic yeast genome by Richardson, Sarah M., Mitchell, Leslie A., Stracquadanio, Giovanni, Yang, Kun, Dymond, Jessica S., DiCarlo, James E., Lee, Dongwon, Huang, Cheng Lai Victor, Chandrasegaran, Srinivasan, Cai, Yizhi, Boeke, Jef D., Bader, Joel S.

“…We describe complete design of a synthetic eukaryotic genome, Sc2.0, a highly modified Saccharomyces cerevisiae genome reduced in size by nearly 8%, with 1.1…”
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Misunderstanding of race as biology has deep negative biological and social consequences by Lujan, Heidi L., DiCarlo, Stephen E.

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Mechanism-based strategies to prevent salt sensitivity and salt-induced hypertension by Kurtz, Theodore W, Pravenec, Michal, DiCarlo, Stephen E

“…High-salt diets are a major cause of hypertension and cardiovascular (CV) disease. Many governments are interested in using food salt reduction programs to…”
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High-throughput creation and functional profiling of DNA sequence variant libraries using CRISPR–Cas9 in yeast by Guo, Xiaoge, Chavez, Alejandro, Tung, Angela, Chan, Yingleong, Kaas, Christian, Yin, Yi, Cecchi, Ryan, Garnier, Santiago Lopez, Kelsic, Eric D, Schubert, Max, DiCarlo, James E, Collins, James J, Church, George M

“…An optimized method to introduce precise modifications into the yeast genome enables high-throughput characterization of the phenotypic effect of mutations…”
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Humor, laughter, learning, and health! A brief review by Savage, Brandon M, Lujan, Heidi L, Thipparthi, Raghavendar R, DiCarlo, Stephen E

“…Human emotions, such as anxiety, depression, fear, joy, and laughter, profoundly affect psychological and physiological processes. These emotions form a set of…”
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Small Amounts of Inorganic Nitrate or Beetroot Provide Substantial Protection From Salt-Induced Increases in Blood Pressure by Morris, R Curtis, Pravenec, Michal, Šilhavý, Jan, DiCarlo, Stephen E, Kurtz, Theodore W

“…To reduce the risk of salt-induced hypertension, medical authorities have emphasized dietary guidelines promoting high intakes of potassium and low intakes of…”
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Local cytokine profiles in knee osteoarthritis: elevated synovial fluid interleukin-15 differentiates early from end-stage disease by Scanzello, C.R, Umoh, E, Pessler, F, Diaz-Torne, C, Miles, T, DiCarlo, E, Potter, H.G, Mandl, L, Marx, R, Rodeo, S, Goldring, S.R, Crow, M.K

“…Summary Objective Much of what is known about the inflammatory response in the synovial membrane (SM) of patients with osteoarthritis (OA) comes from studies…”
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The pivotal role of renal vasodysfunction in salt sensitivity and the initiation of salt-induced hypertension by Kurtz, Theodore W, DiCarlo, Stephen E, Pravenec, Michal, Morris, R Curtis

“…PURPOSE OF REVIEWFor decades, it has been widely accepted that initiation of salt-induced hypertension involves a type of kidney dysfunction (natriuretic…”
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Comparison of mineral quality and quantity in iliac crest biopsies from high- and low-turnover osteoporosis : an FT-IR microspectroscopic investigation by BOSKEY, A. L, DICARLO, E, PASCHALIS, E, WEST, Paul, MENDELSOHN, Richard

“…Fourier-transform infrared microspectroscopy (FTIRM) allows analysis of mineral content, mineral crystal maturity and mineral composition at approximately…”
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An Appraisal of Methods Recently Recommended for Testing Salt Sensitivity of Blood Pressure by Kurtz, Theodore W, DiCarlo, Stephen E, Pravenec, Michal, Morris, Jr, R Curtis

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Cardiac output, at rest and during exercise, before and during myocardial ischemia, reperfusion, and infarction in conscious mice by Lujan, Heidi L, DiCarlo, Stephen E

“…Multiple systems and regulatory strategies interact to control cardiac homeostasis. In fact, regulated systems, feedback controls, and redundant control…”
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In Vivo Evaluation of Autologous Cartilage Fragment-Loaded Scaffolds Implanted Into Equine Articular Defects and Compared With Autologous Chondrocyte Implantation by Frisbie, David D., Lu, Y., Kawcak, Christopher E., DiCarlo, E. F., Binette, F., McIlwraith, C. Wayne

“…Background Current autologous chondrocyte implantation (ACI) techniques require 2 surgical procedures: 1 for cell harvest and 1 for reimplantation of cultured…”
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Changing views on the common physiologic abnormality that mediates salt sensitivity and initiation of salt-induced hypertension: Japanese research underpinning the vasodysfunction theory of salt sensitivity by Kurtz, Theodore W, DiCarlo, Stephen E, Pravenec, Michal, Morris, R Curtis

“…High-salt intake is one of the major dietary determinants of increased blood pressure and cardiovascular disease. Thus, there is scientific and medical…”
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Elevated high-sensitivity C-reactive protein levels are associated with local inflammatory findings in patients with osteoarthritis by Pearle, A.D., M.D, Scanzello, C.R., M.D., Ph.D, George, S., B.A, Mandl, L.A., M.D., M.P.H, DiCarlo, E.F., M.D, Peterson, M., Ph.D, Sculco, T.P., M.D, Crow, M.K., M.D

“…Summary Objective C-reactive protein (CRP) has been associated with disease progression in patients with osteoarthritis (OA), but the reasons for this remain…”
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Hidden in plain sight: urinary Cryptococcus neoformans missed by routine diagnostics in a patient with acute leukemia by Weiss, Zoe F, DiCarlo, James E, Basta, David W, Kent, Stephanie, Liakos, Alexis, Baden, Lindsey, Brigl, Manfred, Kanjilal, Sanjat, Caéete-Gibas, Connie, Wiederhold, Nathan P, Basu, Sankha S

“…Abstract Cryptococcuria is a rare manifestation of localized cryptococcal disease. We present a case of Cryptococcus neoformans urinary tract infection in an…”
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The influence of synovial inflammation and hyperplasia on symptomatic outcomes up to 2 years post-operatively in patients undergoing partial meniscectomy by Scanzello, C.R, Albert, A.S, DiCarlo, E, Rajan, K.B, Kanda, V, Asomugha, E.U, Swaim, B.H, Katz, J.N, Goldring, S.R, Richmond, J.C, McKeon, B

“…Summary Objective Synovitis is associated with pain and other symptoms in patients with knee osteoarthritis (OA), and in patients with meniscal tears even in…”
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Comparable outcomes in fracture reduction and bone properties with RANKL inhibition and alendronate treatment in a mouse model of osteogenesis imperfecta by Bargman, R., Posham, R., Boskey, A. L., DiCarlo, E., Raggio, C., Pleshko, N.

“…Summary We report a direct comparison of receptor activator of nuclear factor kappa B ligand (RANKL) inhibition (RANK-Fc) with bisphosphonate treatment…”
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Reduced arsenic clearance and increased toxicity in aquaglyceroporin-9-null mice by Carbrey, Jennifer M, Song, Linhua, Zhou, Yao, Yoshinaga, Masafumi, Rojek, Aleksandra, Wang, Yiding, Liu, Yangjian, Lujan, Heidi L, DiCarlo, Stephen E, Nielsen, Søren, Rosen, Barry P, Agre, Peter, Mukhopadhyay, Rita

“…Expressed in liver, aquaglyceroporin-9 (AQP9) is permeated by glycerol, arsenite, and other small, neutral solutes. To evaluate a possible protective role,…”
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My gut feeling says rest: Increased intestinal permeability contributes to chronic diseases in high-intensity exercisers by Van Houten, Jason M, Wessells, Robert J, Lujan, Heidi L, DiCarlo, Stephen E

“…Abstract Chronic diseases are the leading cause of death and disability worldwide, and many of these conditions are linked to chronic inflammation. One…”
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