Search Results - "Dibrov, Sergey M."

Correcting pervasive errors in RNA crystallography through enumerative structure prediction by Chou, Fang-Chieh, Sripakdeevong, Parin, Dibrov, Sergey M, Hermann, Thomas, Das, Rhiju

“…A Rosetta algorithm improves RNA structure by scoring each nucleotide's possible conformations based on an energy function and electron-density data…”
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Crystal-Structure-Guided Design of Self-Assembling RNA Nanotriangles by Boerneke, Mark A., Dibrov, Sergey M., Hermann, Thomas

“…RNA nanotechnology uses RNA structural motifs to build nanosized architectures that assemble through selective base‐pair interactions. Herein, we report the…”
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Self-assembling RNA square by Dibrov, Sergey M, McLean, Jaime, Parsons, Jerod, Hermann, Thomas

“…The three-dimensional structures of noncoding RNA molecules reveal recurring architectural motifs that have been exploited for the design of artificial RNA…”
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Conformational inhibition of the hepatitis C virus internal ribosome entry site RNA by Hermann, Thomas, Parsons, Jerod, Castaldi, M Paola, Dutta, Sanjay, Dibrov, Sergey M, Wyles, David L

“…The internal ribosome entry site (IRES), a highly conserved structured element of the hepatitis C virus (HCV) genomic RNA, is an attractive target for…”
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Functional conservation despite structural divergence in ligand-responsive RNA switches by Boerneke, Mark A., Dibrov, Sergey M., Gu, Jing, Wyles, David L., Hermann, Thomas

“…An internal ribosome entry site (IRES) initiates protein synthesis in RNA viruses, including the hepatitis C virus (HCV). We have discovered ligand-responsive…”
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Structure of a hepatitis C virus RNA domain in complex with a translation inhibitor reveals a binding mode reminiscent of riboswitches by Dibrov, Sergey M, Ding, Kejia, Brunn, Nicholas D, Parker, Matthew A, Bergdahl, B. Mikael, Wyles, David L, Hermann, Thomas

“…The internal ribosome entry site (IRES) in the hepatitis C virus (HCV) RNA genome is essential for the initiation of viral protein synthesis. IRES domains…”
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Functional Architecture of HCV IRES Domain II Stabilized by Divalent Metal Ions in the Crystal and in Solution by Dibrov, Sergey M., Johnston-Cox, Hillary, Weng, Yi-Hsin, Hermann, Thomas

“…Around the bend: A right‐angled bend in the RNA of the hepatitis C virus is stabilized by a core of divalent metal ions (shown as green and violet spheres)…”
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Analysis of mRNA recognition by human thymidylate synthase by Brunn, Nicholas D, Dibrov, Sergey M, Kao, Melody B, Ghassemian, Majid, Hermann, Thomas

“…Expression of hTS (human thymidylate synthase), a key enzyme in thymidine biosynthesis, is regulated on the translational level through a feedback mechanism…”
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Crystallographic view of fluidic structures for room-temperature ionic liquids: 1-butyl-3-methylimidazolium hexafluorophosphate by Dibrov, Sergey M, Kochi, Jay K

“…Shock-induced crystallization of the supercooled ionic liquid 1-butyl-3-methylimidazolium hexafluorophosphate, C8H15N2+.PF6-, allows for the first time precise…”
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Structure of the HCV Internal Ribosome Entry Site Subdomain IIa RNA in Complex with a Viral Translation Inhibitor by Dibrov, Sergey M, Hermann, Thomas

“…The internal ribosome entry site (IRES) in the 5' untranslated region (UTR) of the hepatitis C virus (HCV) RNA genome is responsible for initiation of viral…”
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Hepatitis C virus translation inhibitors targeting the internal ribosomal entry site by Dibrov, Sergey M, Parsons, Jerod, Carnevali, Maia, Zhou, Shu, Rynearson, Kevin D, Ding, Kejia, Garcia Sega, Emily, Brunn, Nicholas D, Boerneke, Mark A, Castaldi, Maria P, Hermann, Thomas

“…The internal ribosome entry site (IRES) in the 5' untranslated region (UTR) of the hepatitis C virus (HCV) genome initiates translation of the viral…”
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Aryl-substituted aminobenzimidazoles targeting the hepatitis C virus internal ribosome entry site by Ding, Kejia, Wang, Annie, Boerneke, Mark A., Dibrov, Sergey M., Hermann, Thomas

“…We describe the exploration of N1-aryl-substituted benzimidazoles as ligands for the hepatitis C virus (HCV) internal ribosome entry site (IRES) RNA. The…”
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2-Aminobenzoxazole ligands of the hepatitis C virus internal ribosome entry site by Rynearson, Kevin D, Charrette, Brian, Gabriel, Christopher, Moreno, Jesus, Boerneke, Mark A, Dibrov, Sergey M, Hermann, Thomas

“…2-Aminobenzoxazoles have been synthesized as ligands for the hepatitis C virus (HCV) internal ribosome entry site (IRES) RNA. The compounds were designed to…”
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Synthesis of Oxazole Analogs of Streptolidine Lactam by Rynearson, Kevin D., Dutta, Sanjay, Tran, Kiet, Dibrov, Sergey M., Hermann, Thomas

“…The streptolidine lactam is an amino acid constituent of streptothricin antibiotics, which inhibit protein synthesis by targeting the bacterial ribosome but…”
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model for the study of ligand binding to the ribosomal RNA helix h44 by Dibrov, Sergey M, Parsons, Jerod, Hermann, Thomas

“…Oligonucleotide models of ribosomal RNA domains are powerful tools to study the binding and molecular recognition of antibiotics that interfere with bacterial…”
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Synthesis and Crystal Structure of a Phenazine N-oxide by Ding, Kejia, Dibrov, Sergey M., Hermann, Thomas

“…The preparation and crystal structure of 8-chloro-1 H -pyrrolo[2,3- b ]phenazine5-oxide ( 1 ) are described. Compound 1 formed dark purple crystals from deeply…”
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1,3-Diazepanes of Natural Product-Like Complexity from Cyanamide-Induced Rearrangement of Epoxy-δ-lactams by Dutta, Sanjay, Higginson, Cody J, Ho, Bao T, Rynearson, Kevin D, Dibrov, Sergey M, Hermann, Thomas

“…A synthetic procedure toward 1,3-diazepane scaffolds of natural product-like complexity was developed for the construction of RNA-directed ligand libraries. A…”
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Crystal Structure of a Benzimidazole Hepatitis C Virus Inhibitor Free and in Complex with the Viral RNA Target by Dibrov, Sergey M., Parker, Matthew A., Bergdahl, B. Mikael, Hermann, Thomas

“…The crystal structure of 8-((dimethylamino)methyl)-1-(3-(dimethylamino)propyl)-1,7,8,9-tetrahydrochromeno[5,6-d]imidazol-2-amine ( 1 ), an inhibitor of the…”
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Kristallstruktur-geleitetes Design selbstorganisierender RNA-Nanodreiecke by Boerneke, Mark A., Dibrov, Sergey M., Hermann, Thomas

“…Abstract RNA‐Nanotechnologie nutzt RNA‐Strukturmotive zur Konstruktion von Molekülarchitekturen im Nanomaßstab, die sich durch selektive…”
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Synthesis and Structural Characterization of Some Selenoruthenates and Telluroruthenates by Dibrov, Sergey M, Deng, Bin, Ellis, Donald E, Ibers, James A

“…The reaction of solid [RuClCp(PPh3)2] with TeSe3 2- or Se n 2- in DMF leads to the formation of [RuCp(PPh3)(μ2-Se2)]2 (1). In the structure of this compound…”
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