Search Results - "Dib, Karim"

Histamine Produced by Gram-Negative Bacteria Impairs Neutrophil’s Antimicrobial Response by Engaging the Histamine 2 Receptor by Dib, Karim, El Banna, Amal, Radulescu, Clara, Lopez Campos, Guillermo, Sheehan, Gerard, Kavanagh, Kevin

“…Abstract We found that histamine (10−9 M) did not have any effect on the in vitro capture of Escherichia coli by neutrophils but accelerated its intracellular…”
Get full text

The histamine H4 receptor is a potent inhibitor of adhesion‐dependent degranulation in human neutrophils by Dib, Karim, Perecko, Tomas, Jenei, Veronika, McFarlane, Cheryl, Comer, David, Brown, Vanessa, Katebe, Mwape, Scheithauer, Torsten, Thurmond, Robin L., Chazot, Paul L., Ennis, Madeleine

“…The presence of a functional histamine H4 receptor in neutrophils with anti‐inflammatory properties. The histamine H4 receptor regulates the inflammatory…”
Get full text

The Pro-inflammatory Mediator Leukotriene D4 Induces Phosphatidylinositol 3-Kinase and Rac-dependent Migration of Intestinal Epithelial Cells by Paruchuri, Sailaja, Broom, Oliver, Dib, Karim, Sjölander, Anita

“…Inflammatory bowel diseases are associated with increased risk of developing colon cancer. A possible role of the pro-inflammatory leukotriene D4 (LTD4) in…”
Get full text

USP17 Regulates Ras Activation and Cell Proliferation by Blocking RCE1 Activity by Burrows, James F., Kelvin, Alyson A., McFarlane, Cheryl, Burden, Roberta E., McGrattan, Michael J., De la Vega, Michelle, Govender, Ureshnie, Quinn, Derek J., Dib, Karim, Gadina, Massimo, Scott, Christopher J., Johnston, James A.

“…The proto-oncogene Ras undergoes a series of post-translational modifications at its carboxyl-terminal CAAX motif that are essential for its proper membrane…”
Get full text

Exchange protein directly activated by cAMP 1 (Epac1) is expressed in human neutrophils and mediates cAMP-dependent activation of the monomeric GTPase Rap1 by Dash‐Koney, Madhuri, Deevi, Ravi K., McFarlane, Cheryl, Dib, Karim

“…cAMP regulates Rap1 through Epac1 in human neutrophils. Epac1 and Epac2 bind cAMP and mediate cAMP‐dependent activation of Rap1. cAMP is produced in…”
Get full text

The cytoplasmic tail of L-selectin interacts with the adaptor-protein complex AP-1 subunit μ1A via a novel basic binding motif by Dib, Karim, Tikhonova, Irina G., Ivetic, Aleksandar, Schu, Peter

“…L-selectin regulates leukocyte adhesion and rolling along the endothelium. Proteins binding to the cytoplasmic tail of L-selectin regulate L-selectin…”
Get full text

Vasodilator-Stimulated Phosphoprotein (VASP)-dependent and -independent pathways regulate thrombin-induced activation of Rap1b in platelets by Benz, Peter M, Laban, Hebatullah, Zink, Joana, Günther, Lea, Walter, Ulrich, Gambaryan, Stepan, Dib, Karim

“…Vasodilator-Stimulated Phosphoprotein (VASP) is involved in the inhibition of agonist-induced platelet aggregation by cyclic nucleotides and the adhesion of…”
Get full text

Two Naturally Occurring Mutant Insulin Receptors Phosphorylate Insulin Receptor Substrate-1 (IRS-1) but Fail to Mediate the Biological Effects of Insulin by Krook, Anna, Moller, David E., Dib, Karim, O'Rahilly, Stephen

“…Two naturally occurring mutant insulin receptors, Arg-1174 Gln and Leu-1178 Pro, found in patients with dominantly inherited Type A insulin resistance, showed…”
Get full text

The deubiquitinating enzyme USP17 is essential for GTPase subcellular localization and cell motility by de la Vega, Michelle, Kelvin, Alyson A., Dunican, Dara J., McFarlane, Cheryl, Burrows, James F., Jaworski, Jakub, Stevenson, Nigel J., Dib, Karim, Rappoport, Joshua Z., Scott, Christopher J., Long, Aideen, Johnston, James A.

“…Deubiquitinating enzymes are now emerging as potential therapeutic targets that control many cellular processes, but few have been demonstrated to control cell…”
Get full text

β2 Integrins target Rap GTPases to the plasma membrane by means of degranulation by Dib, Karim, Axelsson, Lena, Andersson, Tommy

“…We report the novel observation that engagement of β2 integrins on human neutrophils is accompanied by increased levels of the small GTPases Rap1 and Rap2 in a…”
Get full text

Vasodilator-Stimulated Phosphoprotein Regulates Inside-Out Signaling of β2 Integrins in Neutrophils by Deevi, Ravi K., Koney-Dash, Madhuri, Kissenpfennig, Adrien, Johnston, James A., Schuh, Kai, Walter, Ulrich, Dib, Karim

“…The monomeric GTPase Rap1 controls functional activation of β2 integrins in leukocytes. In this article, we describe a novel mechanism by which the…”
Get full text

Simvastatin decreases the level of heparin-binding protein in patients with acute lung injury by McAuley, Daniel F, O'Kane, Cecilia M, Craig, Thelma R, Shyamsundar, Murali, Herwald, Heiko, Dib, Karim

“…Heparin-binding protein is released by neutrophils during inflammation and disrupts the integrity of the alveolar and capillary endothelial barrier implicated…”
Get full text

Role of p190RhoGAP in β2 Integrin Regulation of RhoA in Human Neutrophils by Dib, Karim, Melander, Fredrik, Andersson, Tommy

“…We found that engagement of β2 integrins on human neutrophils induced activation of RhoA, as indicated by the increased ratio of GTP:GTP + GDP recovered on…”
Get full text

Engagement of β2 integrins recruits 14-3-3 proteins to c-Cbl in human neutrophils by Melander, Fredrik, Andersson, Tommy, Dib, Karim

“…We found that engagement of β2 integrins on human neutrophils triggered both tyrosine and serine phosphorylation of c-Cbl. Pretreatment of the neutrophils with…”
Get full text

Nitric Oxide Produced in Response to Engagement of beta 2 Integrins on Human Neutrophils Activates the Monomeric GTPases Rap1 and Rap2 and Promotes Adhesion by Jenei, Veronika, Deevi, Ravi Kiran, Adams, Catherine Anne, Axelsson, Lena, Hirst, David Graham, Andersson, Tommy, Dib, Karim

“…We found that engagement of beta 2 integrins on human neutrophils increased the levels of GTP-bound Rap1 and Rap2. Also, the activation of Rap1 was blocked by…”
Get full text

Nitric Oxide Produced in Response to Engagement of β2 Integrins on Human Neutrophils Activates the Monomeric GTPases Rap1 and Rap2 and Promotes Adhesion by Jenei, Veronika, Deevi, Ravi Kiran, Adams, Catherine Anne, Axelsson, Lena, Hirst, David Graham, Andersson, Tommy, Dib, Karim

“…We found that engagement of β2 integrins on human neutrophils increased the levels of GTP-bound Rap1 and Rap2. Also, the activation of Rap1 was blocked by PP1,…”
Get full text

Wnt‐5a and G‐protein signaling are required for collagen‐induced DDR1 receptor activation and normal mammary cell adhesion by Dejmek, Janna, Dib, Karim, Jönsson, Marzieh, Andersson, Tommy

“…The collagen‐induced phosphorylation of discoidin domain receptor 1 (DDR1) in Wnt‐5a‐expressing HB2 mammary cells was effectively inhibited by pertussis toxin,…”
Get full text

Down-regulation of Rac Activity during β2 Integrin-mediated Adhesion of Human Neutrophils by Dib, Karim, Melander, Fredrik, Axelsson, Lena, Dagher, Marie-Claire, Aspenström, Pontus, Andersson, Tommy

Get full text

beta 2 Integrins target Rap GTPases to the plasma membrane by means of degranulation by Dib, K, Axelsson, L, Andersson, T

“…We report the novel observation that engagement of beta 2 integrins on human neutrophils is accompanied by increased levels of the small GTPases Rap1 and Rap2…”
Get full text

Engagement of beta2 integrins recruits 14-3-3 proteins to c-Cbl in human neutrophils by Melander, Fredrik, Andersson, Tommy, Dib, Karim

“…We found that engagement of beta2 integrins on human neutrophils triggered both tyrosine and serine phosphorylation of c-Cbl. Pretreatment of the neutrophils…”
Get full text