Search Results - "Diaz‐Nido, J."

Delivery of the 135 kb human frataxin genomic DNA locus gives rise to different frataxin isoforms by Pérez-Luz, S, Gimenez-Cassina, A, Fernández-Frías, I, Wade-Martins, R, Díaz-Nido, J

“…Friedreich's ataxia (FRDA) is the most common form of hereditary ataxia caused by recessive mutations in the FXN gene. Recent results have indicated the…”
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A cAMP-activated pathway, including PKA and PI3K, regulates neuronal differentiation by Sánchez, S, Jiménez, C, Carrera, A.C, Diaz-Nido, J, Avila, J, Wandosell, F

“…Neuronal differentiation is a complex process in which many different signalling pathways may be involved. An increase in the intracellular levels of cyclic…”
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The inhibition of phosphatidylinositol‐3‐kinase induces neurite retraction and activates GSK3 by Sanchez, S., Sayas, C. L., Lim, F., Diaz‐Nido, J., Avila, J., Wandosell, F.

“…It has been extensively described that neuronal differentiation involves the signalling through neurotrophin receptors to a Ras‐dependent mitogen‐activated…”
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Semaphorin 3C preserves survival and induces neuritogenesis of cerebellar granule neurons in culture by Moreno‐Flores, M. T., Martín‐Aparicio, E., Martín‐Bermejo, M. J., Agudo, M., McMahon, S., Ávila, J., Díaz‐Nido, J., Wandosell, F.

“…Semaphorins (sema) constitute a family of molecules sharing a common extracellular domain (semaphorin domain). This family includes several types of secreted…”
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Implication of brain cdc2 and MAP2 kinases in the phosphorylation of tau protein in Alzheimer's disease by Ledesma, M.D., Correas, I., Avila, J., Diaz-Nido, J.

“…Brain tau protein is phosphorylated in vitro by cdc2 and MAP2 kinases, obtained through immunoaffinity purification from rat brain extracts. The…”
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Phosphorylation of microtubule-associated protein 2 (MAP2) and its relevance for the regulation of the neuronal cytoskeleton function by Sánchez, C, Díaz-Nido, J, Avila, J

“…Neurons, the basic information processing units of the nervous system, are characterized by a complex polar morphology which is essential for their function…”
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Infectious delivery and long-term persistence of transgene expression in the brain by a 135-kb iBAC-FXN genomic DNA expression vector by Gimenez-Cassina, A, Wade-Martins, R, Gomez-Sebastian, S, Corona, J-C, Lim, F, Diaz-Nido, J

“…Novel gene-based therapies for disease will depend in many cases on long-term persistent transgene expression. To develop gene therapy strategies for…”
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Lithium protects cultured neurons against β-amyloid-induced neurodegeneration by Alvarez, Gema, Muñoz-Montaño, Juan Ramón, Satrústegui, Jorgina, Avila, Jesús, Bogónez, Elena, Dı́az-Nido, Javier

“…The deposition of β-amyloid peptide (Aβ), the hyperphosphorylation of tau protein and the death of neurons in certain brain regions are characteristic features…”
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Localization of differentially phosphorylated isoforms of microtubule-associated protein 1B in cultured rat hippocampal neurons by Ulloa, L, Díez-Guerra, F J, Avila, J, Díaz-Nido, J

“…The development and plasticity of axons and dendrites in mammalian neurons may depend on the presence and phosphorylation state of cytoskeletal proteins,…”
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Phosphorylation of a neuronal-specific beta-tubulin isotype by Díaz-Nido, J, Serrano, L, López-Otín, C, Vandekerckhove, J, Avila, J

“…Adult rats were intracraneally injected with [32P] phosphate and brain microtubules isolated. The electrophoretically purified, in vivo phospholabeled,…”
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Pharmacological inhibition of GSK-3 is not strictly correlated with a decrease in tyrosine phosphorylation of residues 216/279 by Simón, D., Benitez, M. J., Gimenez-Cassina, A., Garrido, J. J., Bhat, R. V., Díaz-Nido, J., Wandosell, F.

“…Recent evidence suggests that intramolecular autophosphorylation is responsible for the tyrosine phosphorylation (pY) of residues 279 or 216 of glycogen…”
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N-methyl-D-aspartate stimulates the dephosphorylation of the microtubule-associated protein 2 and potentiates excitatory synaptic pathways in the rat hippocampus by Montoro, R J, Díaz-Nido, J, Avila, J, López-Barneo, J

“…We have studied the effect of brief (50-150 s) applications of N-methyl-D-aspartate (10-100 microM) on the phosphorylated state of the microtubule-associated…”
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Association of casein kinase II with microtubules by Serrano, L, Hernández, M A, Díaz-Nido, J, Avila, J

“…A magnesium-dependent heparin-inhibited protein kinase activity associated with brain microtubule preparations has been identified as casein kinase II using a…”
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Depletion of casein kinase II by antisense oligonucleotide prevents neuritogenesis in neuroblastoma cells by Ulloa, L., Díaz‐Nido, J., Avila, J.

“…Casein kinase II is a multifunctional protein kinase which has been implicated in the regulation of cell growth and differentiation. This enzyme is much more…”
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Microtubule protein phosphorylation in neuroblastoma cells and neurite growth by DIAZ-NIDO, J, ARMAS-PORTELA, R, CORREAS, I, DOMINGUEZ, J. E, MONTEJO, E, AVILA, J

“…The development of highly asymmetrical neurones from undifferentiated neuroblasts involves the extension of processes (axon and dendrites), that depends on the…”
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Regulation of microtubule dynamics by microtubule-associated protein expression and phosphorylation during neuronal development by AVILA, J, DOMINGUEZ, J, DIAZ-NIDO, J

“…Neuronal morphogenesis is driven by cytoskeletal changes in which microtubules play a leading role. A very heterogeneous group of microtubule-associated…”
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Delivery of the 135kb human frataxin genomic DNA locus gives rise to different frataxin isoforms by Pérez-Luz, S., Gimenez-Cassina, A., Fernández-Frías, I., Wade-Martins, R., Díaz-Nido, J.

“…Friedreich's ataxia (FRDA) is the most common form of hereditary ataxia caused by recessive mutations in the FXN gene. Recent results have indicated the…”
Get full text

Regulation of a site-specific phosphorylation of the microtubule-associated protein 2 during the development of cultured neurons by Sánchez, C, Dı́az-Nido, J, Avila, J

“…The phosphorylation state of cytoskeletal proteins, including certain microtubule-associated proteins, may influence the development and plasticity of axons…”
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Implication of cyclin-dependent kinases and glycogen synthase kinase 3 in the phosphorylation of microtubule-associated protein 1B in developing neuronal cells by García-Pérez, Julia, Avila, Jesús, Díaz-Nido, Javier

“…Phosphorylation at certain proline‐directed sites on the microtubule‐associated protein 1B (MAP1B) is a characteristic feature of mitotic neuronal precursor…”
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A Casein Kinase II-Related Activity Is Involved in Phosphorylation of Microtubule-Associated Protein MAP-1B during Neuroblastoma Cell Differentiation by Díaz-Nido, J., Serrano, L., Méndez, E., Avila, J.

“…A neuroblastoma protein related to the brain microtubule-associated protein, MAP-1B, as determined by immunoprecipitation and coassembly with brain…”
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