Cross-sectional characteristics of pediatric-onset discoid lupus erythematosus: Results of a multicenter, retrospective cohort study

The incidence of systemic lupus in children with discoid lupus is unknown. This study assessed the baseline characteristics of patients with pediatric discoid lupus erythematosus (pDLE). Medical records at 17 sites were reviewed for pediatric dermatology and rheumatology patients with discoid lupus...

Full description

Saved in:

Bibliographic Details
Published in:	Journal of the American Academy of Dermatology Vol. 87; no. 3; pp. 559 - 566
Main Authors:	Ezeh, N., Ardalan, K., Buhr, K.A., Nguyen, C., Al Ahmed, O., Ardoin, S.P., Barton, V., Bell, S., Brandling-Bennett, H., Castelo-Soccio, L., Chiu, Y.E., Chong, B.F., Co, D.O., Lara-Corrales, I., Cintosun, A., Curran, M.L., Diaz, L.Z., Elman, S.A., Faith, E. Fernandez, Garcia-Romero, M.T., Grossman-Kranseler, J., Hogeling, M., Hudson, A.D., Hunt, R.D., Ibler, E.M., Marques, M.C., Monir, R.L., Oza, V., Paller, A.S., Putterman, E., Rodriguez-Salgado, P., Schoch, J.J., Truong, A., Wang, J., Lee, L. Wine, Vleugels, R.A., Klein-Gitelman, M.S., von Scheven, E., Werth, V.P., Arkin, Lisa.M.
Format:	Journal Article
Language:	English
Published:	United States Elsevier Inc 01-09-2022
Subjects:	Adolescent Child Cohort Studies Cross-Sectional Studies discoid lupus erythematosus Female Humans Lupus Erythematosus, Discoid - diagnosis Lupus Erythematosus, Discoid - epidemiology Lupus Erythematosus, Systemic - epidemiology Male pediatric pediatric dermatology pediatric rheumatology Retrospective Studies systemic lupus erythematosus ACR systemic lupus erythematosus pediatric rheumatology ANA SLICC pediatric dermatology DLE SLE pDLE discoid lupus erythematosus pediatric
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	The incidence of systemic lupus in children with discoid lupus is unknown. This study assessed the baseline characteristics of patients with pediatric discoid lupus erythematosus (pDLE). Medical records at 17 sites were reviewed for pediatric dermatology and rheumatology patients with discoid lupus erythematosus. The inclusion criteria were clinical and/or histopathologic diagnosis of discoid lupus erythematosus with an age at onset of <18 years. Baseline data were collected at the first documented visit. Outcomes included diagnosis of systemic lupus erythematosus (SLE) at the baseline visit using the 1997 American College of Rheumatology (primary) and the 2012 Systemic Lupus International Collaborating Clinics (secondary) criteria. Of the >1500 charts reviewed, 438 patients met the inclusion criteria. The cohort was predominantly female (72%) and racially/ethnically diverse. A diagnosis of SLE at the baseline visit (pDLE + SLE) was rendered in 162 (37%) patients using the American College of Rheumatology and in 181 (41%) patients using the Systemic Lupus International Collaborating Clinics criteria. Patients with pDLE + SLE were older at the time of rash onset (median, 12.9 vs 8.9 years; P < .001), with shorter time from discoid lupus erythematosus onset to diagnosis, compared with patients with pDLE-only (median, 2 vs 7 months; P < .001). Patients with pDLE + SLE were more likely to be female (P = .004), with generalized discoid lupus erythematosus and clinically aggressive disease, including end-organ involvement, positive serologies, and higher- titer levels of antinuclear antibodies (P < .001). Retrospective study. A diagnosis of discoid lupus erythematosus in adolescence should prompt thorough screening for SLE.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 Equal effort
ISSN:	0190-9622 1097-6787
DOI:	10.1016/j.jaad.2022.04.028