Search Results - "Diaz, H. Bruce"

LY2606368 Causes Replication Catastrophe and Antitumor Effects through CHK1-Dependent Mechanisms by King, Constance, Diaz, H Bruce, McNeely, Samuel, Barnard, Darlene, Dempsey, Jack, Blosser, Wayne, Beckmann, Richard, Barda, David, Marshall, Mark S

“…CHK1 is a multifunctional protein kinase integral to both the cellular response to DNA damage and control of the number of active replication forks. CHK1…”
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LY2603618, a selective CHK1 inhibitor, enhances the anti-tumor effect of gemcitabine in xenograft tumor models by Barnard, Darlene, Diaz, H. Bruce, Burke, Teresa, Donoho, Gregory, Beckmann, Richard, Jones, Bonita, Barda, David, King, Constance, Marshall, Mark

“…Summary Pharmacological inhibition of CHK1 in the absence of p53 functionality leads to abrogation of the S and G2/M DNA damage checkpoints. We report the…”
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PAK1 Phosphorylation of MEK1 Regulates Fibronectin-Stimulated MAPK Activation by Slack-Davis, Jill K., Eblen, Scott T., Zecevic, Maja, Boerner, Scott A., Tarcsafalvi, Adel, Diaz, H. Bruce, Marshall, Mark S., Weber, Michael J., Parsons, J. Thomas, Catling, Andrew D.

“…Activation of the Ras-MAPK signal transduction pathway is necessary for biological responses both to growth factors and ECM. Here, we provide evidence that…”
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Preclinical analyses and phase I evaluation of LY2603618 administered in combination with Pemetrexed and cisplatin in patients with advanced cancer by Calvo, Emiliano, Chen, Victor J., Marshall, Mark, Ohnmacht, Ute, Hynes, Scott M., Kumm, Elizabeth, Diaz, H. Bruce, Barnard, Darlene, Merzoug, Farhana F., Huber, Lysiane, Kays, Lisa, Iversen, Philip, Calles, Antonio, Voss, Beatrice, Lin, Aimee Bence, Dickgreber, Nicolas, Wehler, Thomas, Sebastian, Martin

“…Summary LY2603618 is an inhibitor of checkpoint kinase 1 (CHK1), an important regulator of the DNA damage checkpoints. Preclinical experiments analyzed…”
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Abstract B248: Characterization and preclinical development of LCI-1, a selective and potent Chk1 inhibitor in phase 1 clinical trials by Marshall, Mark, Barda, David, Barnard, Darlene, Cox, Karen, Diaz, H. Bruce, King, Constance, Nutter, Suzanne, Westin, Eric

“…Abstract Interference of DNA damage checkpoints has been demonstrated to be a highly effective means of increasing the cytotoxicity of a wide number of…”
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Regulation of the protein kinase Raf-1 by oncogenic Ras through phosphatidylinositol 3-kinase, Cdc42/Rac and Pak by Sun, Huaiyu, King, Alastair J., Diaz, H.Bruce, Marshall, Mark S.

“…Activation of the protein kinase Raf-1 is a complex process involving association with the GTP-bound form of Ras (Ras–GTP), membrane translocation and both…”
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