Search Results - "Diaz, Caridad"

Permutation tests for ASCA in multivariate longitudinal intervention studies by Camacho, José, Díaz, Caridad, Sánchez‐Rovira, Pedro

“…Permutation tests are the standard technique for significance testing in Analysis of Variance Simultaneous Component Analysis. However, there is a vast number…”
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MDN-0171, a new medermycin analogue from Streptomyces albolongus CA-186053 by Lacret, Rodney, Oves-Costales, Daniel, Pérez-Victoria, Ignacio, de la Cruz, Mercedes, Díaz, Caridad, Vicente, Francisca, Genilloud, Olga, Reyes, Fernando

“…A new medermycin derivative, MDN-0171 (1), and two known structurally related compounds, medermycin (2) and antibiotic G15-F (3) were isolated from the acetone…”
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Zebrafish-Based Discovery of Antiseizure Compounds from the Red Sea: Pseurotin A2 and Azaspirofuran A by Copmans, Daniëlle, Rateb, Mostafa, Tabudravu, Jioji N, Pérez-Bonilla, Mercedes, Dirkx, Nina, Vallorani, Riccardo, Diaz, Caridad, Pérez del Palacio, José, Smith, Alan J, Ebel, Rainer, Reyes, Fernando, Jaspars, Marcel, de Witte, Peter A. M

“…In search for novel antiseizure drugs (ASDs), the European FP7-funded PharmaSea project used zebrafish embryos and larvae as a drug discovery platform to…”
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Preclinical Evaluation of an Imidazole-Linked Heterocycle for Alzheimer’s Disease by Bagán, Andrea, Rodriguez-Arévalo, Sergio, Taboada-Jara, Teresa, Griñán-Ferré, Christian, Pallàs, Mercè, Brocos-Mosquera, Iria, Callado, Luis F, Morales-García, José A, Pérez, Belén, Diaz, Caridad, Fernández-Godino, Rosario, Genilloud, Olga, Beljkas, Milan, Oljacic, Slavica, Nikolic, Katarina, Escolano, Carmen

“…Humanity is facing a vast prevalence of neurodegenerative diseases, with Alzheimer’s disease (AD) being the most dominant, without efficacious drugs, and with…”
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A novel in vitro approach for simultaneous evaluation of CYP3A4 inhibition and kinetic aqueous solubility by Pérez, José, Díaz, Caridad, Asensio, Francisco, Palafox, Alexandra, Genilloud, Olga, Vicente, Francisca

“…In the early stages of the drug discovery process, evaluation of the drug metabolism and physicochemical properties of new chemical entities is crucial to…”
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Novel Biomarkers to Distinguish between Type 3c and Type 2 Diabetes Mellitus by Untargeted Metabolomics by Jimenez-Luna, Cristina, Martin-Blazquez, Ariadna, Dieguez-Castillo, Carmelo, Diaz, Caridad, Martin-Ruiz, Jose Luis, Genilloud, Olga, Vicente, Francisca, del Palacio, Jose Perez, Prados, Jose, Caba, Octavio

“…Pancreatogenic diabetes mellitus (T3cDM) is a highly frequent complication of pancreatic disease, especially chronic pancreatitis, and it is often misdiagnosed…”
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Metabolomics signature as a survival predictor in patients with resectable colorectal liver metastasis by González‐Olmedo, Carmen, García‐Verdejo, Francisco José, Reguera‐Teba, Antonio, Rosa‐Garrido, Carmen, López‐López, José Antonio, Díaz‐Beltrán, Leticia, García, Patricia Mena, Luque‐Caro, Natalia, Gálvez‐Montosa, Fernando, Ortega‐Granados, Ana Laura, Ruiz‐Sanjuan, María, Cózar‐Ibáñez, Antonio, Sainz, Juan, Marchal, Juan Antonio, Camacho, José, Palacio, José Pérez, Fernández‐Godino, Rosario, Díaz, Caridad, Sánchez‐Rovira, Pedro

“…Statistical analyses showed that 346 metabolites were differentially expressed pre- and post-surgery, which could be used to discriminate the metastatic…”
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Amphidinol 22, a New Cytotoxic and Antifungal Amphidinol from the Dinoflagellate Amphidinium carterae by Martínez, Kevin A, Lauritano, Chiara, Druka, Dana, Romano, Giovanna, Grohmann, Teresa, Jaspars, Marcel, Martín, Jesús, Díaz, Caridad, Cautain, Bastien, de la Cruz, Mercedes, Ianora, Adrianna, Reyes, Fernando

“…Due to the unique biodiversity and the physical-chemical properties of their environment, marine microorganisms have evolved defense and signaling compounds…”
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Branimycins B and C, Antibiotics Produced by the Abyssal Actinobacterium Pseudonocardia carboxydivorans M‑227 by Braña, Alfredo F, Sarmiento-Vizcaíno, Aida, Pérez-Victoria, Ignacio, Otero, Luis, Fernández, Jonathan, Palacios, Juan José, Martín, Jesús, de la Cruz, Mercedes, Díaz, Caridad, Vicente, Francisca, Reyes, Fernando, García, Luis A, Blanco, Gloria

“…Two new antibiotics, branimycins B (2) and C (3), were produced by fermentation of the abyssal actinobacterium Pseudonocardia carboxydivorans M-227, isolated…”
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Identification of Compounds with Potential Therapeutic Uses from Sweet Pepper ( Capsicum annuum L.) Fruits and Their Modulation by Nitric Oxide (NO) by Guevara, Lucía, Domínguez-Anaya, María Ángeles, Ortigosa, Alba, González-Gordo, Salvador, Díaz, Caridad, Vicente, Francisca, Corpas, Francisco J, Pérez Del Palacio, José, Palma, José M

“…Plant species are precursors of a wide variety of secondary metabolites that, besides being useful for themselves, can also be used by humans for their…”
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Crossiellidines A–F, Unprecedented Pyrazine-Alkylguanidine Metabolites with Broad-Spectrum Antibacterial Activity from Crossiella sp by Ortiz-López, Francisco Javier, Oves-Costales, Daniel, Carretero-Molina, Daniel, Martín, Jesús, Díaz, Caridad, de la Cruz, Mercedes, Román-Hurtado, Fernando, Álvarez-Arévalo, María, Jørgensen, Tue Sparholt, Reyes, Fernando, Weber, Tilmann, Genilloud, Olga

“…Crosiellidines are intriguing pyrazine-alkylguanidine metabolites isolated from the minor actinomycete genus Crossiella. Their structures present an…”
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Discovery and Characterization of Epemicins A and B, New 30-Membered Macrolides from Kutzneria sp. CA-103260 by Kontou, Eftychia Eva, Gren, Tetiana, Ortiz-López, Francisco Javier, Thomsen, Emil, Oves-Costales, Daniel, Díaz, Caridad, de la Cruz, Mercedes, Jiang, Xinglin, Jørgensen, Tue Sparholt, Blin, Kai, Charusanti, Pep, Reyes, Fernando, Genilloud, Olga, Weber, Tilmann

“…Actinobacteria have been a rich source of novel, structurally complex natural products for many decades. Although the largest genus is Streptomyces, from which…”
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Untargeted LC-HRMS-based metabolomics to identify novel biomarkers of metastatic colorectal cancer by Martín-Blázquez, Ariadna, Díaz, Caridad, González-Flores, Encarnación, Franco-Rivas, Daniel, Jiménez-Luna, Cristina, Melguizo, Consolación, Prados, José, Genilloud, Olga, Vicente, Francisca, Caba, Octavio, Pérez del Palacio, José

“…Colorectal cancer is one of the main causes of cancer death worldwide, and novel biomarkers are urgently needed for its early diagnosis and treatment. The…”
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Diketopiperazines and other bioactive compounds from bacterial symbionts of marine sponges by Santos, José Diogo, Vitorino, Inês, de la Cruz, Mercedes, Díaz, Caridad, Cautain, Bastien, Annang, Frederick, Pérez-Moreno, Guiomar, Gonzalez, Ignacio, Tormo, José Ruben, Martin, Jesus, Vicente, Maria Francisca, Lage, Olga Maria

“…Humanity faces great challenges, such as the rise of bacterial antibiotic resistance and cancer incidence. Thus, the discovery of novel therapeutics from…”
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Evaluation of pro-regenerative and anti-inflammatory effects of isolecanoric acid in the muscle: Potential treatment of Duchenne Muscular Dystrophy by Matias-Valiente, Lidia, Sanchez-Fernandez, Cristina, Rodriguez-Outeiriño, Lara, Ramos, Maria C., Díaz, Caridad, Crespo, Gloria, González-Menéndez, Victor, Genilloud, Olga, Reyes, Fernando, Montolio, Marisol, Hernandez-Torres, Francisco, Aranega, Amelia Eva

“…Duchenne muscular dystrophy (DMD) is a devastating degenerative disease of skeletal muscles caused by loss of dystrophin, a key protein that maintains muscle…”
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Pentaminomycins F and G, Nonribosomal Peptides Containing 2‑Pyridylalanine by Carretero-Molina, Daniel, Ortiz-López, Francisco Javier, Martín, Jesús, González, Ignacio, Sánchez-Hidalgo, Marina, Román-Hurtado, Fernando, Díaz, Caridad, de la Cruz, Mercedes, Genilloud, Olga, Reyes, Fernando

“…Pentaminomycins F–H (1–3), a group of three new hydroxyarginine-containing cyclic pentapeptides, were isolated from cultures of a Streptomyces cacaoi subsp…”
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Metabolomic profile of cancer stem cell‐derived exosomes from patients with malignant melanoma by Palacios‐Ferrer, José Luis, García‐Ortega, María Belén, Gallardo‐Gómez, María, García, María Ángel, Díaz, Caridad, Boulaiz, Houria, Valdivia, Javier, Jurado, José Miguel, Almazan‐Fernandez, Francisco M., Arias‐Santiago, Salvador, Amezcua, Víctor, Peinado, Héctor, Vicente, Francisca, Pérez del Palacio, José, Marchal, Juan A.

“…Malignant melanoma (MM) is the most aggressive form of skin cancer, with increasing incidence worldwide. To date, there are no suitable clinical diagnostic,…”
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Assessment of Untargeted Metabolomics by Hydrophilic Interaction Liquid Chromatography-Mass Spectrometry to Define Breast Cancer Liquid Biopsy-Based Biomarkers in Plasma Samples by González Olmedo, Carmen, Díaz Beltrán, Leticia, Madrid García, Verónica, Palacios Ferrer, José Luis, Cano Jiménez, Alicia, Urbano Cubero, Rocío, Pérez Del Palacio, José, Díaz, Caridad, Vicente, Francisca, Sánchez Rovira, Pedro

“…An early diagnosis of cancer is fundamental not only in regard to reducing its mortality rate but also in terms of counteracting the progression of the tumor…”
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New ikarugamycin derivatives with antifungal and antibacterial properties from Streptomyces zhaozhouensis by Lacret, Rodney, Oves-Costales, Daniel, Gómez, Cristina, Díaz, Caridad, de la Cruz, Mercedes, Pérez-Victoria, Ignacio, Vicente, Francisca, Genilloud, Olga, Reyes, Fernando

“…A bioassay guided fractionation of the ethyl acetate extract from culture broths of the strain Streptomyces zhaozhouensis CA-185989 led to the isolation of…”
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New Napyradiomycin Analogues from Streptomyces sp. Strain CA-271078 by Carretero-Molina, Daniel, Ortiz-López, Francisco Javier, Martín, Jesús, Oves-Costales, Daniel, Díaz, Caridad, de la Cruz, Mercedes, Cautain, Bastien, Vicente, Francisca, Genilloud, Olga, Reyes, Fernando

“…As part of our continuing efforts to discover new bioactive compounds from microbial sources, a reinvestigation of extracts of scaled-up cultures of the…”
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