Search Results - "Diaz, Aaron"

Loss of ATRX suppresses anti-tumor immunity by Diaz, Aaron A

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Single-cell analysis of long non-coding RNAs in the developing human neocortex by Liu, Siyuan John, Nowakowski, Tomasz J, Pollen, Alex A, Lui, Jan H, Horlbeck, Max A, Attenello, Frank J, He, Daniel, Weissman, Jonathan S, Kriegstein, Arnold R, Diaz, Aaron A, Lim, Daniel A

“…Long non-coding RNAs (lncRNAs) comprise a diverse class of transcripts that can regulate molecular and cellular processes in brain development and disease…”
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Single-cell profiling of human gliomas reveals macrophage ontogeny as a basis for regional differences in macrophage activation in the tumor microenvironment by Müller, Sören, Kohanbash, Gary, Liu, S John, Alvarado, Beatriz, Carrera, Diego, Bhaduri, Aparna, Watchmaker, Payal B, Yagnik, Garima, Di Lullo, Elizabeth, Malatesta, Martina, Amankulor, Nduka M, Kriegstein, Arnold R, Lim, Daniel A, Aghi, Manish, Okada, Hideho, Diaz, Aaron

“…Tumor-associated macrophages (TAMs) are abundant in gliomas and immunosuppressive TAMs are a barrier to emerging immunotherapies. It is unknown to what extent…”
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ATRX regulates glial identity and the tumor microenvironment in IDH-mutant glioma by Babikir, Husam, Wang, Lin, Shamardani, Karin, Catalan, Francisca, Sudhir, Sweta, Aghi, Manish K, Raleigh, David R, Phillips, Joanna J, Diaz, Aaron A

“…Recent single-cell transcriptomic studies report that IDH-mutant gliomas share a common hierarchy of cellular phenotypes, independent of genetic subtype…”
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Outer Radial Glia-like Cancer Stem Cells Contribute to Heterogeneity of Glioblastoma by Bhaduri, Aparna, Di Lullo, Elizabeth, Jung, Diane, Müller, Sören, Crouch, Elizabeth Erin, Espinosa, Carmen Sandoval, Ozawa, Tomoko, Alvarado, Beatriz, Spatazza, Julien, Cadwell, Cathryn René, Wilkins, Grace, Velmeshev, Dmitry, Liu, Siyuan John, Malatesta, Martina, Andrews, Madeline Gail, Mostajo-Radji, Mohammed Andres, Huang, Eric Jinsheng, Nowakowski, Tomasz Jan, Lim, Daniel Amos, Diaz, Aaron, Raleigh, David Ronan, Kriegstein, Arnold Richard

“…Glioblastoma is a devastating form of brain cancer. To identify aspects of tumor heterogeneity that may illuminate drivers of tumor invasion, we created a…”
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Molecular Identity of Human Outer Radial Glia during Cortical Development by Pollen, Alex A., Nowakowski, Tomasz J., Chen, Jiadong, Retallack, Hanna, Sandoval-Espinosa, Carmen, Nicholas, Cory R., Shuga, Joe, Liu, Siyuan John, Oldham, Michael C., Diaz, Aaron, Lim, Daniel A., Leyrat, Anne A., West, Jay A., Kriegstein, Arnold R.

“…Radial glia, the neural stem cells of the neocortex, are located in two niches: the ventricular zone and outer subventricular zone. Although outer…”
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The evolution of alternative splicing in glioblastoma under therapy by Wang, Lin, Shamardani, Karin, Babikir, Husam, Catalan, Francisca, Nejo, Takahide, Chang, Susan, Phillips, Joanna J, Okada, Hideho, Diaz, Aaron A

“…Alternative splicing is a rich source of tumor-specific neoantigen targets for immunotherapy. This holds promise for glioblastomas (GBMs), the most common…”
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A single-cell atlas of glioblastoma evolution under therapy reveals cell-intrinsic and cell-extrinsic therapeutic targets by Wang, Lin, Jung, Jangham, Babikir, Husam, Shamardani, Karin, Jain, Saket, Feng, Xi, Gupta, Nalin, Rosi, Susanna, Chang, Susan, Raleigh, David, Solomon, David, Phillips, Joanna J, Diaz, Aaron A

“…Recent longitudinal studies of glioblastoma (GBM) have demonstrated a lack of apparent selection pressure for specific DNA mutations in recurrent disease…”
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Single-cell RNA sequencing and spatial transcriptomics reveal cancer-associated fibroblasts in glioblastoma with protumoral effects by Jain, Saket, Rick, Jonathan W, Joshi, Rushikesh S, Beniwal, Angad, Spatz, Jordan, Gill, Sabraj, Chang, Alexander Chih-Chieh, Choudhary, Nikita, Nguyen, Alan T, Sudhir, Sweta, Chalif, Eric J, Chen, Jia-Shu, Chandra, Ankush, Haddad, Alexander F, Wadhwa, Harsh, Shah, Sumedh S, Choi, Serah, Hayes, Josie L, Wang, Lin, Yagnik, Garima, Costello, Joseph F, Diaz, Aaron, Heiland, Dieter Henrik, Aghi, Manish K

“…Cancer-associated fibroblasts (CAFs) were presumed absent in glioblastoma given the lack of brain fibroblasts. Serial trypsinization of glioblastoma specimens…”
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Single-Cell mRNA Sequencing in Cancer Research: Integrating the Genomic Fingerprint by Müller, Sören, Diaz, Aaron

“…Critical cancer mutations are often regional and mosaic, confounding the efficacy of targeted therapeutics. Single cell mRNA sequencing (scRNA-seq) has enabled…”
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HiTSelect: a comprehensive tool for high-complexity-pooled screen analysis by Diaz, Aaron A, Qin, Han, Ramalho-Santos, Miguel, Song, Jun S

“…Genetic screens of an unprecedented scale have recently been made possible by the availability of high-complexity libraries of synthetic oligonucleotides…”
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The landscape of tumor cell states and spatial organization in H3-K27M mutant diffuse midline glioma across age and location by Liu, Ilon, Jiang, Li, Samuelsson, Erik R., Marco Salas, Sergio, Beck, Alexander, Hack, Olivia A., Jeong, Daeun, Shaw, McKenzie L., Englinger, Bernhard, LaBelle, Jenna, Mire, Hafsa M., Madlener, Sibylle, Mayr, Lisa, Quezada, Michael A., Trissal, Maria, Panditharatna, Eshini, Ernst, Kati J., Vogelzang, Jayne, Gatesman, Taylor A., Halbert, Matthew E., Palova, Hana, Pokorna, Petra, Sterba, Jaroslav, Slaby, Ondrej, Geyeregger, Rene, Diaz, Aaron, Findlay, Izac J., Dun, Matthew D., Resnick, Adam, Suvà, Mario L., Jones, David T. W., Agnihotri, Sameer, Svedlund, Jessica, Koschmann, Carl, Haberler, Christine, Czech, Thomas, Slavc, Irene, Cotter, Jennifer A., Ligon, Keith L., Alexandrescu, Sanda, Yung, W. K. Alfred, Arrillaga-Romany, Isabel, Gojo, Johannes, Monje, Michelle, Nilsson, Mats, Filbin, Mariella G.

“…Histone 3 lysine27-to-methionine (H3-K27M) mutations most frequently occur in diffuse midline gliomas (DMGs) of the childhood pons but are also increasingly…”
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Thermoregulation via Temperature-Dependent PGD2 Production in Mouse Preoptic Area by Wang, Tongfei A., Teo, Chin Fen, Åkerblom, Malin, Chen, Chao, Tynan-La Fontaine, Marena, Greiner, Vanille Juliette, Diaz, Aaron, McManus, Michael T., Jan, Yuh Nung, Jan, Lily Y.

“…Body temperature control is essential for survival. In mammals, thermoregulation is mediated by the preoptic area of anterior hypothalamus (POA), with ∼30% of…”
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The Transcriptionally Permissive Chromatin State of Embryonic Stem Cells Is Acutely Tuned to Translational Output by Bulut-Karslioglu, Aydan, Macrae, Trisha A., Oses-Prieto, Juan A., Covarrubias, Sergio, Percharde, Michelle, Ku, Gregory, Diaz, Aaron, McManus, Michael T., Burlingame, Alma L., Ramalho-Santos, Miguel

“…A permissive chromatin environment coupled to hypertranscription drives the rapid proliferation of embryonic stem cells (ESCs) and peri-implantation embryos…”
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TIGIT and PD-1 Immune Checkpoint Pathways Are Associated With Patient Outcome and Anti-Tumor Immunity in Glioblastoma by Raphael, Itay, Kumar, Rajeev, McCarl, Lauren H, Shoger, Karsen, Wang, Lin, Sandlesh, Poorva, Sneiderman, Chaim T, Allen, Jordan, Zhai, Shuyan, Campagna, Marissa Lynn, Foster, Alexandra, Bruno, Tullia C, Agnihotri, Sameer, Hu, Baoli, Castro, Brandyn A, Lieberman, Frank S, Broniscer, Alberto, Diaz, Aaron A, Amankulor, Nduka M, Rajasundaram, Dhivyaa, Pollack, Ian F, Kohanbash, Gary

“…Glioblastoma (GBM) remains an aggressive brain tumor with a high rate of mortality. Immune checkpoint (IC) molecules are expressed on tumor infiltrating…”
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The immune suppressive microenvironment of human gliomas depends on the accumulation of bone marrow-derived macrophages in the center of the lesion by Pinton, Laura, Masetto, Elena, Vettore, Marina, Solito, Samantha, Magri, Sara, D'Andolfi, Marta, Del Bianco, Paola, Lollo, Giovanna, Benoit, Jean-Pierre, Okada, Hideho, Diaz, Aaron, Della Puppa, Alessandro, Mandruzzato, Susanna

“…Systemic and local immune suppression plays a significant role in glioma progression. Glioma microenvironment contains both brain-resident microglial cells…”
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Clonal ZEB1-Driven Mesenchymal Transition Promotes Targetable Oncologic Antiangiogenic Therapy Resistance by Chandra, Ankush, Jahangiri, Arman, Chen, William, Nguyen, Alan T, Yagnik, Garima, Pereira, Matheus P, Jain, Saket, Garcia, Joseph H, Shah, Sumedh S, Wadhwa, Harsh, Joshi, Rushikesh S, Weiss, Jacob, Wolf, Kayla J, Lin, Jung-Ming G, Müller, Sören, Rick, Jonathan W, Diaz, Aaron A, Gilbert, Luke A, Kumar, Sanjay, Aghi, Manish K

“…Glioblastoma (GBM) responses to bevacizumab are invariably transient with acquired resistance. We profiled paired patient specimens and bevacizumab-resistant…”
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miRNA-independent function of long noncoding pri-miRNA loci by He, Daniel, Wu, David, Muller, Soren, Wang, Lin, Saha, Parna, Ahanger, Sajad Hamid, Liu, Siyuan John, Cui, Miao, Hong, Sung Jun, Jain, Miten, Olson, Hugh E., Akeson, Mark, Costello, Joseph F., Diaz, Aaron, Lim, Daniel A.

“…Among the large, diverse set of mammalian long noncoding RNAs (lncRNAs), long noncoding primary microRNAs (lnc-pri-miRNAs) are those that host miRNAs. Whether…”
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Challenges in the discovery of tumor-specific alternative splicing-derived cell-surface antigens in glioma by Nejo, Takahide, Wang, Lin, Leung, Kevin K., Wang, Albert, Lakshmanachetty, Senthilnath, Gallus, Marco, Kwok, Darwin W., Hong, Chibo, Chen, Lee H., Carrera, Diego A., Zhang, Michael Y., Stevers, Nicholas O., Maldonado, Gabriella C., Yamamichi, Akane, Watchmaker, Payal B., Naik, Akul, Shai, Anny, Phillips, Joanna J., Chang, Susan M., Wiita, Arun P., Wells, James A., Costello, Joseph F., Diaz, Aaron A., Okada, Hideho

“…Despite advancements in cancer immunotherapy, solid tumors remain formidable challenges. In glioma, profound inter- and intra-tumoral heterogeneity of antigen…”
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Exosomal PD-L1 induces immunosuppressive nonclassical monocytes by Diaz, Aaron A

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