Search Results - "Dias Lopes, Júlio César"
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Synthesis of Novel 1,2,3-Triazole Derivatives of Isocoumarins and 3,4-Dihydroisocoumarin with Potential Antiplasmodial Activity In Vitro
Published in Medicinal chemistry (Shp-sariqah, United Arab Emirates) (01-01-2021)“…Malaria greatly affects the world health, having caused more than 228 million cases only in 2018. The emergence of drug resistance is one of the main problems…”
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Investigação eletroquímica e calorimétrica da interação de novos agentes antitumorais biscatiônicos com DNA
Published in Química Nova (2012)“…Biscationic amidines bind in the DNA minor groove and present biological activity against a range of infectious diseases. Two new biscationic compounds…”
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Combined In Vitro Studies and in Silico Target Fishing for the Evaluation of the Biological Activities of Diphylleia cymosa and Podophyllum hexandrum
Published in Molecules (Basel, Switzerland) (13-12-2018)“…This paper reports the in silico prediction of biological activities of lignans from and combined with an in vitro bioassays. The extracts from the leaves,…”
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Conformational analysis and electronic interactions of 2-thiosubstituted cyclohexanones by semiempirical method PM3
Published in International journal of quantum chemistry (2003)“…Some 2‐phenylthio‐para–substituted cyclohexanones with different oxidation states of sulfur atom were studied by systematic conformational search around C–S…”
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Aspidosperma species: A review of their chemistry and biological activities
Published in Journal of ethnopharmacology (01-03-2019)“…Species of Aspidosperma are known popularly as “peroba, guatambu, carapanaúba, pau-pereiro” and “quina”. The genus can be found in the Americas, mainly between…”
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In vitro antileishmanial activity of leaf and stem extracts of seven Brazilian plant species
Published in Journal of ethnopharmacology (25-03-2019)“…Leishmaniasis is a parasitic disease that affects people all over the world. The number of cases of leishmaniasis is increasing and the drugs used for its…”
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Biological activities of extracts from Aspidosperma subincanum Mart. and in silico prediction for inhibition of acetylcholinesterase
Published in Phytotherapy research (01-10-2018)“…Species of Aspidosperma are traditionally used to treat malaria, leishmaniasis, microbial, and inflammatory diseases. Aspidosperma subincanum Mart. known as…”
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The power metric: a new statistically robust enrichment-type metric for virtual screening applications with early recovery capability
Published in Journal of cheminformatics (02-02-2017)“…A new metric for the evaluation of model performance in the field of virtual screening and quantitative structure–activity relationship applications is…”
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Estudos de relações estrutura-atividade quantitativas (QSAR) de bis-benzamidinas com atividade antifúngica Quantitative structure-activity relationships (QSAR) studies of bisbenzamidines with antifungal activity
Published in Química nova (01-01-2010)“…This paper describes 2D-QSAR and 3D-QSAR studies against Candida albicans and Cryptococcus neofarmans for a set of 20 bisbenzamidines. In the studies of…”
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Estudos de relações estrutura-atividade quantitativas (QSAR) de bis-benzamidinas com atividade antifúngica
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A QSAR Study on Pneumocystis carinii Topoisomerases of bis-Benzimidazoles
Published in Quantitative structure-activity relationships (01-04-2000)“…QSARs are presented for interactions between bis‐benzimidazoles and DNA denaturation temperatures and topo‐isomerases I and II of Pneumocystis carinii. A Carbo…”
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In silico pharmacological prediction and cytotoxicity of flavonoids glycosides identified by UPLC-DAD-ESI-MS/MS in extracts of Humulus lupulus leaves cultivated in Brazil
Published in Natural product research (07-08-2020)“…Ethanolic (EB) extract and hexanic (SH) and hydromethanolic (SEM) sub-extracts of leaves were submitted to cytotoxicity evaluation and to phytochemical…”
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The Tropical Biominer Project: mining old sources for new drugs
Published in Omics (Larchmont, N.Y.) (01-06-2005)“…The Tropical Biominer Project is a recent initiative from the Federal University of Minas Gerais (UFMG) and the Oswaldo Cruz foundation, with the participation…”
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In silico pharmacological prediction and cytotoxicity of flavonoids glycosides identified by UPLC-DAD-ESI-MS/MS in extracts of Humulus lupulus leaves cultivated in Brazil
Published in Natural Product Research (17-12-2021)“…Ethanolic (EB) extract and hexanic (SH) and hydromethanolic (SEM) sub-extracts of Humulus lupulus leaves were submitted to cytotoxicity evaluation and to…”
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