Tracking the turnover of SARS-CoV-2 VOCs Gamma to Delta in a Brazilian state (Minas Gerais) with a high-vaccination status

Abstract The emergence and global dissemination of Severe Acute Respiratory Syndrome virus 2 (SARS-CoV-2) variants of concern (VOCs) have been described as the main factor driving the Coronavirus Disease 2019 pandemic. In Brazil, the Gamma variant dominated the epidemiological scenario during the fi...

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Bibliographic Details
Published in:	Virus evolution Vol. 8; no. 2; p. veac064
Main Authors:	Fonseca, Paula L C, Moreira, Filipe R R, de Souza, Rafael M, Guimarães, Natália R, Carvalho, Nara O, Adelino, Talita E R, Alves, Hugo J, Alvim, Luige B, Candido, Darlan S, Coelho, Helena P, Costa, Alana V B, Costa, Walyson C, de Carvalho, Alex F, de Faria, Bruna W F, de Lima, Aline B, de Oliveira, Eneida S, de Souza, Carolina S A, de Souza, Fernanda G, Dias, Rillery C, Geddes, Victor E V, Godinho, Igor P, Gonçalves, Alessandro L, Lourenço, Karine L, Magalhães, Rubens D M, Malta, Frederico S V, Medeiros, Eva L A, Mendes, Fernanda S, Mendes, Pedro H B de P, Mendonça, Cristiane P T B, Menezes, Andre L, Menezes, Diego, Menezes, Mariane T, Miguita, Lucyene, Moreira, Rennan G, Peixoto, Renata B, Queiroz, Daniel C, Ribeiro, Adriana A, Ribeiro, Ana Paula de B, Saliba, Juliana W, Sato, Hugo I, Silva, Joice do P, Silva, Natiely P, Faria, Nuno R, Teixeira, Santuza M R, da Fonseca, Flávio G, Fernandes, Ana Paula S M, Zauli, Danielle A G, Januario, José Nélio, de Oliveira, Jaqueline S, Iani, Felipe C de M, de Aguiar, Renato S, de Souza, Renan P
Format:	Journal Article
Language:	English
Published:	UK Oxford University Press 01-07-2022
Subjects:	phylogeny Genomic surveillance viral lineages vaccines phylogeography
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Summary:	Abstract The emergence and global dissemination of Severe Acute Respiratory Syndrome virus 2 (SARS-CoV-2) variants of concern (VOCs) have been described as the main factor driving the Coronavirus Disease 2019 pandemic. In Brazil, the Gamma variant dominated the epidemiological scenario during the first period of 2021. Many Brazilian regions detected the Delta variant after its first description and documented its spread. To monitor the introduction and spread of VOC Delta, we performed Polymerase Chain Reaction (PCR) genotyping and genome sequencing in ten regional sentinel units from June to October 2021 in the State of Minas Gerais (MG). We documented the introduction and spread of Delta, comprising 70 per cent of the cases 8 weeks later. Comparing the viral loads of the Gamma and Delta dominance periods, we provide additional evidence that the latter is more transmissible. The spread and dominance of Delta did not culminate in the increase in cases and deaths, suggesting that the vaccination may have restrained the epidemic growth. Analysis of 224 novel Delta genomes revealed that Rio de Janeiro state was the primary source for disseminating this variant in the state of MG. We present the establishment of Delta, providing evidence of its enhanced transmissibility and showing that this variant shift did not aggravate the epidemiological scenario in a high immunity setting.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 https://orcid.org/0000-0001-5180-9983 These first authors contributed equally to this article. https://orcid.org/0000-0002-3629-8529 share the senior authorship.
ISSN:	2057-1577 2057-1577
DOI:	10.1093/ve/veac064