Search Results - "Dias, Ricardo L.A"

Peptidomimetic Antibiotics Target Outer-Membrane Biogenesis in Pseudomonas aeruginosa by Srinivas, Nityakalyani, Jetter, Peter, Ueberbacher, Bernhard J, Werneburg, Martina, Zerbe, Katja, Steinmann, Jessica, Van der Meijden, Benjamin, Bernardini, Francesca, Lederer, Alexander, Dias, Ricardo L.A, Misson, Pauline E, Henze, Heiko, Zumbrunn, Jürg, Gombert, Frank O, Obrecht, Daniel, Hunziker, Peter, Schauer, Stefan, Ziegler, Urs, Käch, Andres, Eberl, Leo, Riedel, Kathrin, DeMarco, Steven J, Robinson, John A

“…Antibiotics with new mechanisms of action are urgently required to combat the growing health threat posed by resistant pathogenic microorganisms. We…”
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Structure-Activity Studies in a Family of β-Hairpin Protein Epitope Mimetic Inhibitors of the p53-HDM2 Protein-Protein Interaction by Fasan, Rudi, Dias, Ricardo L.A, Moehle, Kerstin, Zerbe, Oliver, Obrecht, Daniel, Mittl, Peer R.E, Grütter, Markus G, Robinson, John A

“…Inhibitors of the interaction between the p53 tumor-suppressor protein and its natural human inhibitor HDM2 are attractive as potential anticancer agents. In…”
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Using a β-Hairpin To Mimic an α-Helix: Cyclic Peptidomimetic Inhibitors of the p53-HDM2 Protein-Protein Interaction by Fasan, Rudi, Dias, Ricardo L. A., Moehle, Kerstin, Zerbe, Oliver, Vrijbloed, Jan W., Obrecht, Daniel, Robinson, John A.

“…Inhibition of crucial protein–protein interactions, for example, between the p53 tumor suppressor (red in structure) and HDM2, a protein overexpressed in tumor…”
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Structure-Guided Peptidomimetic Design Leads to Nanomolar β-Hairpin Inhibitors of the Tat−TAR Interaction of Bovine Immunodeficiency Virus by Athanassiou, Zafiria, Patora, Krystyna, Dias, Ricardo L. A, Moehle, Kerstin, Robinson, John A, Varani, Gabriele

“…The Tat protein of immunodeficiency viruses is the main activator of viral gene expression. By binding specifically to its cognate site, the transactivator…”
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Protein Ligand Design:  From Phage Display to Synthetic Protein Epitope Mimetics in Human Antibody Fc-Binding Peptidomimetics by Dias, Ricardo L. A, Fasan, Rudi, Moehle, Kerstin, Renard, Annabelle, Obrecht, Daniel, Robinson, John A

“…Phage display is a powerful method for selecting peptides with novel binding functions. Synthetic peptidomimetic chemistry is a powerful tool for creating…”
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Structural Mimicry of Retroviral Tat Proteins by Constrained β-Hairpin Peptidomimetics:  Ligands with High Affinity and Selectivity for Viral TAR RNA Regulatory Elements by Athanassiou, Zafiria, Dias, Ricardo L. A, Moehle, Kerstin, Dobson, Neil, Varani, Gabriele, Robinson, John A

“…An approach is described to the design of β-hairpin peptidomimetic ligands for bovine immunodeficiency virus (BIV) Tat protein, which inhibit binding to its…”
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TAR RNA Recognition by a Cyclic Peptidomimetic of Tat Protein by Leeper, Thomas C, Athanassiou, Zafiria, Dias, Ricardo L. A, Robinson, John A, Varani, Gabriele

“…The search for new antiviral drugs that repress HIV viral replication by blocking transactivation of viral RNA transcription has long been advocated as an…”
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Preparation and evaluation of a coumarin library towards the inhibitory activity of the enzyme gGAPDH from Trypanosoma cruzi by Alvim Jr, Joel, Dias, Ricardo L. A., Castilho, Marcelo S., Oliva, Glaucius, Corrêa, Arlene G.

“…Chagas' disease, caused by Trypanosoma cruzi, is endemic in 15 countries in Latin America. In this work a library of 38 coumarins was prepared in solution…”
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