Impact of long COVID on the heart rate variability at rest and during deep breathing maneuver

While the majority of individuals with coronavirus disease 2019 (COVID-19) recover completely, a significant percentage experience persistent symptom, which has been characterized as Long COVID and may be associated with cardiac and autonomic dysfunction. We evaluated heart rate variability (HRV) at...

Full description

Saved in:

Bibliographic Details
Published in:	Scientific reports Vol. 13; no. 1; p. 22695
Main Authors:	da Silva, Andréa Lúcia Gonçalves, Vieira, Luana dos Passos, Dias, Luiza Scheffer, Prestes, Cecília Vieira, Back, Guilherme Dionir, Goulart, Cassia da Luz, Arena, Ross, Borghi-Silva, Audrey, Trimer, Renata
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 20-12-2023 Nature Publishing Group Nature Portfolio
Subjects:	692/4019 692/699 Autonomic Nervous System Coronaviruses COVID-19 Heart Heart diseases Heart rate Heart Rate - physiology Humanities and Social Sciences Humans multidisciplinary Post-Acute COVID-19 Syndrome Respiration Science Science (multidisciplinary)
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	While the majority of individuals with coronavirus disease 2019 (COVID-19) recover completely, a significant percentage experience persistent symptom, which has been characterized as Long COVID and may be associated with cardiac and autonomic dysfunction. We evaluated heart rate variability (HRV) at rest and during deep-breathing (M-RSA) in patients with Long COVID. Case–control design involved 21 patients with Long COVID and 20 controls; the HRV was evaluated (POLAR system) at rest in the supine position and during M-RSA and expressed in time domain and non-linear analysis. In the supine position we found a reduction HRV measures in Long COVID’ patients compared to controls for: Mean_iRR ( p < 0.001), STD_iRR ( p < 0.001); STD_HR ( p < 0.001); SD1 ( p < 0.001); SD2 ( p < 0.001); alpha2 ( p < 0.001). In the M-RSA we found reduction Mean_iRR ( p < 0.001), STD_iRR ( p < 0.001), STD_HR ( p < 0.001), rMSSD ( p < 0.001), RR_tri-index ( p < 0.001) in Long COVID’ patients except for highest Mean_HR p < 0.001. In conclusion, Long COVID reduced HRV at rest and during deep breathing. These findings may imply impairment of cardiac autonomic control when symptoms of COVID-19 persist following initial recovery.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	2045-2322 2045-2322
DOI:	10.1038/s41598-023-50276-0