Modification of Antibiotic Activity by Fixed Oil of the Artocarpus heterophyllus Almond against Standard and Multidrug-Resistant Bacteria Strains

Modification of Antibiotic Activity by Fixed Oil of the Artocarpus heterophyllus Almond against Standard and Multidrug-Resistant Bacteria Strains

(jackfruit) is an evergreen tree distributed in tropical regions and is among the most studied species of the genus . The jackfruit almond has been highlighted in relation to phytochemical studies, biological properties, and application in the development of food products. This study aimed to analyz...

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Bibliographic Details
Published in:Biology (Basel, Switzerland) Vol. 11; no. 12; p. 1835
Main Authors: Dias, Cícera Janayne Ferreira, Raposo, António, de Sousa, Cícera Dayane Thais, de Araújo-Neto, José Bezerra, Tintino, Saulo Relison, Oliveira-Tintino, Cícera Datiane de Morais, Araújo, Isaac Moura, Coutinho, Henrique Douglas Melo, Costa, Mayra Garcia Maia, Lima, Cleidiane Gomes, de Alencar, Mairlane Silva, Carrascosa, Conrado, Saraiva, Ariana, de Sousa, Erlânio Oliveira
Format: Journal Article
Language:English
Published: Switzerland MDPI AG 16-12-2022
MDPI
Subjects:
antibacterial
Antibacterial activity
antibiotic resistance
Antibiotics
Artocarpus heterophyllus
Bacteria
Bacterial infections
E coli
fatty acid
Fatty acids
Fluoroquinolones
Food products
Gas chromatography
Gentamicin
Ionization
jackfruit
Laboratories
Lauric acid
Minimum inhibitory concentration
Multidrug resistance
Ofloxacin
Oleic acid
Palmitic acid
Penicillin
Permeability
Strains (organisms)
Tropical environment
β-Lactam antibiotics
Brazil
fatty acid
antibacterial
antibiotic resistance
jackfruit
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Summary:(jackfruit) is an evergreen tree distributed in tropical regions and is among the most studied species of the genus . The jackfruit almond has been highlighted in relation to phytochemical studies, biological properties, and application in the development of food products. This study aimed to analyze jackfruit fixed oil regarding chemical components, antibacterial property alone, and in association with antibiotics against standard and MDR bacteria strains. In the analysis of the oil by gas chromatography coupled to a flame ionization detector (GC-FID), a high content of saturated fatty acids (78.51%) was identified in relation to unsaturated fatty acids (17.07%). The main fatty acids identified were lauric acid (43.01%), myristic acid (11.10%), palmitic acid (6.95%), and oleic acid (15.32%). In the antibacterial analysis, broth microdilution assays were used. The oil presented minimum inhibitory concentration (MIC) ≥ 1024 μg/mL in antibacterial analysis for standard and MDR bacterial strains. The oil showed synergistic effects in the association with gentamicin, ofloxacin, and penicillin against MDR strains, with significant reductions in the MIC of antibiotics. The results suggest that the fixed oil of has fatty acids with the potential to synergistically modify antibiotic activity.
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ISSN:2079-7737
2079-7737
DOI:10.3390/biology11121835