Effect of chlorhexidine chip as an adjunct in non-surgical management of periodontal pockets: a meta-analysis

Effect of chlorhexidine chip as an adjunct in non-surgical management of periodontal pockets: a meta-analysis

The aim of this meta-analysis was to evaluate the difference in treatment outcomes between sub-gingival placement of chlorhexidine chip (CHX chip) in adjunct to scaling and root planing (SRP) and SRP alone for the management of periodontal pockets in patients suffering from chronic periodontitis. We...

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Bibliographic Details
Published in:BMC oral health Vol. 20; no. 1; p. 262
Main Authors: Ma, Lili, Diao, Xiuchun
Format: Journal Article
Language:English
Published: England BioMed Central Ltd 21-09-2020
BioMed Central
BMC
Subjects:
Anti-Infective Agents, Local - therapeutic use
Antimicrobial agents
Bias
Care and treatment
Chlorhexidine
Chlorhexidine - therapeutic use
Chlorhexidine Chip
Chronic periodontitis
Chronic Periodontitis - drug therapy
Clinical outcomes
Clinical trials
Controlled release technology
Dental plaque
Dental Scaling
Dentistry
Disease
Gum disease
Humans
Meta-analysis
Patient outcomes
Patients
Periodontal Pocket - drug therapy
Periodontal pockets
Periodontics
Periodontitis
Root Planing
Scaling and root Planing
Software
Systematic review
China
United States > US
Scaling and root Planing
Chronic periodontitis
Chlorhexidine Chip
Periodontal pockets
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Summary:The aim of this meta-analysis was to evaluate the difference in treatment outcomes between sub-gingival placement of chlorhexidine chip (CHX chip) in adjunct to scaling and root planing (SRP) and SRP alone for the management of periodontal pockets in patients suffering from chronic periodontitis. We searched the MEDLINE (PubMed), SCOPUS and CENTRAL databases and identified 15 randomized clinical trials published within the last decade (2007-2019): 9 with split-mouth design and 6 with parallel study design. We extracted data and performed both qualitative and quantitative syntheses. The primary outcomes assessed were gain in clinical attachment level (CAL), reduction in probing pocket depth (PPD), improvement in gingival inflammation, and results of microbiological assays. We used meta-analysis plots to assess all the clinical outcomes. The mean differences in PPD reductions at 1 month (MD 0.63), 3 months (MD 0.69), and 6 months (MD 0.75); and the CAL gains at 1 month (MD 0.54), 3 months (MD 0.64), and 6 months (MD 0.68) showed more favorable responses in sites treated with the CHX chip as an adjuvant to SRP, than in sites treated with SRP alone. SRP with adjunctive CHX chips showed better clinical outcomes than SRP alone for the management of periodontal pockets in patients with chronic periodontitis.
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ISSN:1472-6831
1472-6831
DOI:10.1186/s12903-020-01247-8