Search Results - "Diao, Liyang"

A Phase 1b Safety Study of SER-287, a Spore-Based Microbiome Therapeutic, for Active Mild to Moderate Ulcerative Colitis by Henn, Matthew R., O’Brien, Edward J., Diao, Liyang, Feagan, Brian G., Sandborn, William J., Huttenhower, Curtis, Wortman, Jennifer R., McGovern, Barbara H., Wang-Weigand, Sherry, Lichter, David I., Chafee, Meghan, Ford, Christopher B., Bernardo, Patricia, Zhao, Peng, Simmons, Sheri, Tomlinson, Amelia D., Cook, David N., Pomerantz, Roger J., Misra, Bharat K., Auninš, John G., Trucksis, Michele

“…Firmicutes bacteria produce metabolites that maintain the intestinal barrier and mucosal immunity. Firmicutes are reduced in the intestinal microbiota of…”
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Distance-Based Analysis with Quantile Regression Models by Li, Shaoyu, Sun, Yanqing, Diao, Liyang, Wang, Xue

“…Non-standard structured, multivariate data are emerging in many research areas, including genetics and genomics, ecology, and social science. Suitably defined…”
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Sporulation genes associated with sporulation efficiency in natural isolates of yeast by Tomar, Parul, Bhatia, Aatish, Ramdas, Shweta, Diao, Liyang, Bhanot, Gyan, Sinha, Himanshu

“…Yeast sporulation efficiency is a quantitative trait and is known to vary among experimental populations and natural isolates. Some studies have uncovered the…”
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572 PYX-102, an anti-KLRG1 antibody, enhances cytotoxic activity of CD8-T-cells from PBMC and human tumor samples by blocking the interaction between KLRG1 and cadherins by Yasuda, Kei, Diao, Liyang, Feng, Jianwen, Iovino, Matthew, Lewandowski, Sara, Rodriguez, Anthony, Steiner, Philipp, Felitsky, Dan, Herbst, Ronald, Keller, Ben, Miller, Ona, Quigley, Alyssa, Pinkas, Jan

“…BackgroundKLRG1 is an inhibitory receptor expressed on T and NK-cells. On CD8-T-cells, KLRG1 is expressed on highly differentiated antigen-specific effector…”
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SER-109, an Oral Microbiome Therapy for Recurrent Clostridioides difficile Infection by Feuerstadt, Paul, Louie, Thomas J, Lashner, Bret, Wang, Elaine E.L, Diao, Liyang, Bryant, Jessica A, Sims, Matthew, Kraft, Colleen S, Cohen, Stuart H, Berenson, Charles S, Korman, Louis Y, Ford, Christopher B, Litcofsky, Kevin D, Lombardo, Mary-Jane, Wortman, Jennifer R, Wu, Henry, Auniņš, John G, McChalicher, Christopher W.J, Winkler, Jonathan A, McGovern, Barbara H, Trucksis, Michele, Henn, Matthew R, von Moltke, Lisa

“…A major challenge with the treatment of Clostridioides difficile infection is restoring the antibiotic-associated alterations of bowel flora to a state less…”
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Abstract 1373: Gene expression correlation of immune checkpoint molecules Siglec-15 and PD-L1 varies widely by cancer indication by Watkins, Krystal, Diao, Liyang, Crochiere, Marsha, Pinkas, Jan

“…Abstract Siglec-15 is a novel target for immunotherapy in cancer and exhibits low mRNA expression in normal tissues but broad expression across cancer…”
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Abstract 2908: EDB+FN is an attractive therapeutic target in oncology: Insights from protein expression analysis of solid tumors by Lewandowski, Sara, Diao, Liyang, Quigley, Alyssa, Crochiere, Marsha, Pinkas, Jan

“…Abstract Stroma plays a major role in the initiation, growth, survival, and drug-resistance of solid tumors, yet few therapeutics specifically target…”
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P075 SER-287, AN INVESTIGATIONAL MICROBIOME THERAPEUTIC, INDUCES WIDESPREAD METABOLOMIC AND HOST TRANSCRIPTIONAL CHANGES RELATED TO CLINICAL REMISSION IN PATIENTS WITH ACTIVE MILD-TO-MODERATE ULCERATIVE COLITIS by Diao, Liyang, O'Brien, Edward, Ford, Christopher, Wortman, Jennifer, Aunins, John, Henn, Matthew

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809 RAPID CONVERSION OF PRIMARY TO SECONDARY BILE ACIDS IN SUBJECTS WITH RECURRENT CLOSTRIDIOIDES DIFFICILE INFECTION (CDI) FOLLOWING SER-109, AN INVESTIGATIONAL MICROBIOME THERAPEUTIC by Bryant, Jessica A., Diao, Liyang, O'Brien, Edward J., Ford, Christopher B., Litcofsky, Kevin D., Wortman, Jennifer R., Henn, Matthew R.

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P075 SER-287, AN INVESTIGATIONAL MICROBIOME THERAPEUTIC, INDUCES WIDESPREAD METABOLOMIC AND HOST TRANSCRIPTIONAL CHANGES RELATED TO CLINICAL REMISSION IN PATIENTS WITH ACTIVE MILD-TO-MODERATE ULCERATIVE COLITIS by Diao, Liyang, O’Brien, Edward, Ford, Christopher, Wortman, Jennifer, Aunins, John, Henn, Matthew

“…Abstract Background Firmicute bacteria and the metabolites they produce are perturbed in ulcerative colitis (UC) patients. SER-287, an oral formulation of live…”
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Prospective longitudinal evaluation of microbiome diversity in patients with hematological malignancy undergoing allogeneic hematopoietic stem cell transplantation (HSCT) by Walsh, Emily, Tsakmaklis, Anastasia, Diao, Liyang, Bryant, Jessica, Lombardo, Mary-Jane, McGovern, Barbara, von Moltke, Lisa, Henn, Matthew R., Ford, Christopher B., Vehreschild, Maria J.G.T.

“…Abstract only 7005 Background: Studies suggest that decreased microbial diversity due to chemotherapeutic and antibiotic exposure may be associated with acute…”
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Impact of a Purified Microbiome Therapeutic on Abundance of Antimicrobial Resistance Genes in Patients With Recurrent Clostridioides difficile Infection by Straub, Timothy J, Lombardo, Mary-Jane, Bryant, Jessica A, Diao, Liyang, Lodise, Thomas P, Freedberg, Daniel E, Wortman, Jennifer R, Litcofsky, Kevin D, Hasson, Brooke R, McGovern, Barbara H, Ford, Christopher B, Henn, Matthew R

“…Abstract Background The gastrointestinal microbiota is an important line of defense against colonization with antimicrobial resistant (AR) bacteria. In this…”
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Local ancestry corrects for population structure in Saccharomyces cerevisiae genome-wide association studies by Diao, Liyang, Chen, Kevin C

“…Genome-wide association studies (GWAS) have become an important method for mapping the genetic loci underlying complex phenotypic traits in many species. A…”
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35 SER-287, AN INVESTIGATIONAL MICROBIOME THERAPEUTIC, INDUCES IN VIVO AND IN VITRO METABOLOMIC CHANGES ASSOCIATED WITH CLINICAL REMISSION IN PATIENTS WITH ACTIVE MILD-TO-MODERATE ULCERATIVE COLITIS by OBrien, Edward, Diao, Liyang, Kieser, Karen, Balasubramanian, Divya, Nandakumar, Madhu, Pina, Ambar, Martinez, Asuncion, Ford, Christopher B., Wortman, Jennifer R., Auninš, John, Henn, Matthew R.

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681 SER-301, AN INVESTIGATIONAL, RATIONALLY-DESIGNED BACTERIAL CONSORTIUM FOR MILD-TO-MODERATE ULCERATIVE COLITIS, RECAPITULATES THE EFFECTS OF SER-287, A CONSORTIUM OF FIRMICUTE SPORES, ON REMISSION ASSOCIATED MICROBIAL METABOLITES AND HOST GENE EXPRESSION by Martinez, Asuncion, O'Brien, Edward J., Balasubramanian, Divya, Chafee, Meghan, Pina, Ambar, Narendar, Priyanka, Kieser, Karen J., Vulic, Marin, Diao, Liyang, Weiner, Brian, Ford, Christopher B., Wortman, Jennifer R., Henn, Matthew R.

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Tu2019 - Engraftment of Ser-287, an Investigational Microbiome Therapeutic, is Related to Clinical Remission in a Placebo-Controlled, Double-Blind Randomized Trial (Seres-101) in Patients with Active Mild to Moderate Ulcerative Colitis (UC) by Simmons, Sheri, Diao, Liyang, O'Brien, Edward, Chafee, Meghan, Zhao, Jeff, Bernardo, Patricia, Cook, David, Trucksis, Michele, Henn, Matthew R.

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623 – Ser-287, an Investigational Microbiome Therapeutic, Induces Widespread Transcriptional Changes Related to Clinical Remission in a Placebo-Controlled, Double-Blind Randomized Trial (Seres-101) in Patients with Active Mild-To-Moderate Ulcerative Colitis by Diao, Liyang, Nnamani, Mauris C., OBrien, Edward, Desjardins, Christopher, Martinez, Asuncion, Simmons, Sheri, Litcofsky, Kevin, McGovern, Babara, Weigand, Sherry, Cook, David, Wortman, Jennifer R., Henn, Matthew R.

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MixMir: microRNA motif discovery from gene expression data using mixed linear models by Diao, Liyang, Marcais, Antoine, Norton, Scott, Chen, Kevin C

“…microRNAs (miRNAs) are a class of ∼22nt non-coding RNAs that potentially regulate over 60% of human protein-coding genes. miRNA activity is highly specific,…”
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Abstract 742: PYX-201, a stroma-targeting ADC composed of an anti-EDB+FN antibody conjugated to Auristatin0101, demonstrates strong anti-tumor efficacy across multiple human cancer indications in pre-clinical PDX tumor models by Severe, Nicolas, Facklam, Amanda, McMichael, Liz, Das, Biplab, Lewandowski, Sara, Trickett, Justin, Diao, Liyang, Merriman, Chengfeng, Shen, Chuan, Feng, Jianwen, Harriman, Shawn, Crochiere, Marsha, Steiner, Philipp, Pinkas, Jan

“…Abstract Stroma is crucial to support solid tumor growth, metastasis and resistance to treatment. While most antibody-drug conjugates (ADCs) directly bind to…”
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85 - SER-287, an Investigational Microbiome Therapeutic, Induces Remission and Endoscopic Improvement in a Placebo-Controlled, Double-Blind Randomized Trial in Patients with Active Mild-to-Moderate Ulcerative Colitis by Bharat, Misra, Curran, John, Herfarth, Hans H., Jagarlamudi, Kiran, Oneto, Caterina, Bhandari, Bal R., Wiener, Gregory, Kerman, David H., Moss, Alan C., Pomerantz, Roger, Zhao, Jeff, Bernardo, Patricia, Simmons, Sheri, Diao, Liyang, O'Brien, Edward, Henn, Matthew R., Trucksis, Michele

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