Search Results - "Diao, Lixia"

Sex-associated molecular differences for cancer immunotherapy by Ye, Youqiong, Jing, Ying, Li, Liang, Mills, Gordon B., Diao, Lixia, Liu, Hong, Han, Leng

“…Immune checkpoint blockade therapies have extended patient survival across multiple cancer lineages, but there is a heated debate on whether cancer…”
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Small non-coding RNAs in human cancer: function, clinical utility, and characterization by Zhang, Zhao, Zhang, Jian, Diao, Lixia, Han, Leng

“…Small non-coding RNAs (sncRNAs) play critical roles in multiple regulatory processes, including transcription, post-transcription, and translation. Emerging…”
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Multi-omics prediction of immune-related adverse events during checkpoint immunotherapy by Jing, Ying, Liu, Jin, Ye, Youqiong, Pan, Lei, Deng, Hui, Wang, Yushu, Yang, Yang, Diao, Lixia, Lin, Steven H., Mills, Gordon B., Zhuang, Guanglei, Xue, Xinying, Han, Leng

“…Immune-related adverse events (irAEs), caused by anti-PD-1/PD-L1 antibodies, can lead to fulminant and even fatal consequences and thus require early detection…”
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Collagen promotes anti-PD-1/PD-L1 resistance in cancer through LAIR1-dependent CD8+ T cell exhaustion by Peng, David H., Rodriguez, Bertha Leticia, Diao, Lixia, Chen, Limo, Wang, Jing, Byers, Lauren A., Wei, Ying, Chapman, Harold A., Yamauchi, Mitsuo, Behrens, Carmen, Raso, Gabriela, Soto, Luisa Maren Solis, Cuentes, Edwin Roger Parra, Wistuba, Ignacio I., Kurie, Jonathan M., Gibbons, Don L.

“…Tumor extracellular matrix has been associated with drug resistance and immune suppression. Here, proteomic and RNA profiling reveal increased collagen levels…”
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TANRIC: An Interactive Open Platform to Explore the Function of lncRNAs in Cancer by Li, Jun, Han, Leng, Roebuck, Paul, Diao, Lixia, Liu, Lingxiang, Yuan, Yuan, Weinstein, John N, Liang, Han

“…Long noncoding RNAs (lncRNA) have emerged as essential players in cancer biology. Using recent large-scale RNA-seq datasets, especially those from The Cancer…”
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Targeting AXL and mTOR Pathway Overcomes Primary and Acquired Resistance to WEE1 Inhibition in Small-Cell Lung Cancer by Sen, Triparna, Tong, Pan, Diao, Lixia, Li, Lerong, Fan, Youhong, Hoff, Jennifer, Heymach, John V, Wang, Jing, Byers, Lauren Averett

“…Drugs targeting DNA repair and cell-cycle checkpoints have emerged as promising therapies for small-cell lung cancer (SCLC). Among these, the WEE1 inhibitor…”
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A Multi-Omics Perspective of Quantitative Trait Loci in Precision Medicine by Ye, Youqiong, Zhang, Zhao, Liu, Yaoming, Diao, Lixia, Han, Leng

“…Quantitative trait loci (QTL) analysis is an important approach to investigate the effects of genetic variants identified through an increasing number of…”
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Transcriptional landscape and clinical utility of enhancer RNAs for eRNA-targeted therapy in cancer by Zhang, Zhao, Lee, Joo-Hyung, Ruan, Hang, Ye, Youqiong, Krakowiak, Joanna, Hu, Qingsong, Xiang, Yu, Gong, Jing, Zhou, Bingying, Wang, Li, Lin, Chunru, Diao, Lixia, Mills, Gordon B., Li, Wenbo, Han, Leng

“…Enhancer RNA (eRNA) is a type of noncoding RNA transcribed from the enhancer. Although critical roles of eRNA in gene transcription control have been…”
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Th17 cells contribute to combination MEK inhibitor and anti-PD-L1 therapy resistance in KRAS/p53 mutant lung cancers by Peng, David H., Rodriguez, B. Leticia, Diao, Lixia, Gaudreau, Pierre-Olivier, Padhye, Aparna, Konen, Jessica M., Ochieng, Joshua K., Class, Caleb A., Fradette, Jared J., Gibson, Laura, Chen, Limo, Wang, Jing, Byers, Lauren A., Gibbons, Don. L.

“…Understanding resistance mechanisms to targeted therapies and immune checkpoint blockade in mutant KRAS lung cancers is critical to developing novel…”
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Structure-based classification predicts drug response in EGFR-mutant NSCLC by Robichaux, Jacqulyne P., Le, Xiuning, Vijayan, R. S. K., Hicks, J. Kevin, Heeke, Simon, Elamin, Yasir Y., Lin, Heather Y., Udagawa, Hibiki, Skoulidis, Ferdinandos, Tran, Hai, Varghese, Susan, He, Junqin, Zhang, Fahao, Nilsson, Monique B., Hu, Lemei, Poteete, Alissa, Rinsurongkawong, Waree, Zhang, Xiaoshan, Ren, Chenghui, Liu, Xiaoke, Hong, Lingzhi, Zhang, Jianjun, Diao, Lixia, Madison, Russell, Schrock, Alexa B., Saam, Jennifer, Raymond, Victoria, Fang, Bingliang, Wang, Jing, Ha, Min Jin, Cross, Jason B., Gray, Jhanelle E., Heymach, John V.

“…Epidermal growth factor receptor ( EGFR ) mutations typically occur in exons 18–21 and are established driver mutations in non-small cell lung cancer (NSCLC) 1…”
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A Patient-Derived, Pan-Cancer EMT Signature Identifies Global Molecular Alterations and Immune Target Enrichment Following Epithelial-to-Mesenchymal Transition by Mak, Milena P, Tong, Pan, Diao, Lixia, Cardnell, Robert J, Gibbons, Don L, William, William N, Skoulidis, Ferdinandos, Parra, Edwin R, Rodriguez-Canales, Jaime, Wistuba, Ignacio I, Heymach, John V, Weinstein, John N, Coombes, Kevin R, Wang, Jing, Byers, Lauren Averett

“…We previously demonstrated the association between epithelial-to-mesenchymal transition (EMT) and drug response in lung cancer using an EMT signature derived…”
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CD38-Mediated Immunosuppression as a Mechanism of Tumor Cell Escape from PD-1/PD-L1 Blockade by Chen, Limo, Diao, Lixia, Yang, Yongbin, Yi, Xiaohui, Rodriguez, B Leticia, Li, Yanli, Villalobos, Pamela A, Cascone, Tina, Liu, Xi, Tan, Lin, Lorenzi, Philip L, Huang, Anfei, Zhao, Qiang, Peng, Di, Fradette, Jared J, Peng, David H, Ungewiss, Christin, Roybal, Jonathon, Tong, Pan, Oba, Junna, Skoulidis, Ferdinandos, Peng, Weiyi, Carter, Brett W, Gay, Carl M, Fan, Youhong, Class, Caleb A, Zhu, Jingfen, Rodriguez-Canales, Jaime, Kawakami, Masanori, Byers, Lauren Averett, Woodman, Scott E, Papadimitrakopoulou, Vassiliki A, Dmitrovsky, Ethan, Wang, Jing, Ullrich, Stephen E, Wistuba, Ignacio I, Heymach, John V, Qin, F Xiao-Feng, Gibbons, Don L

“…Although treatment with immune checkpoint inhibitors provides promising benefit for patients with cancer, optimal use is encumbered by high resistance rates…”
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Association Between Sex and Immune-Related Adverse Events During Immune Checkpoint Inhibitor Therapy by Jing, Ying, Zhang, Yongchang, Wang, Jing, Li, Kunyan, Chen, Xue, Heng, Jianfu, Gao, Qian, Ye, Youqiong, Zhang, Zhao, Liu, Yaoming, Lou, Yanyan, Lin, Steven H, Diao, Lixia, Liu, Hong, Chen, Xiang, Mills, Gordon B, Han, Leng

“…Abstract Background Accumulated evidence supports the existence of sex-associated differences in immune systems. Understanding the role of sex in…”
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The EMT activator ZEB1 accelerates endosomal trafficking to establish a polarity axis in lung adenocarcinoma cells by Banerjee, Priyam, Xiao, Guan-Yu, Tan, Xiaochao, Zheng, Veronica J., Shi, Lei, Rabassedas, Maria Neus Bota, Guo, Hou-fu, Liu, Xin, Yu, Jiang, Diao, Lixia, Wang, Jing, Russell, William K., Roszik, Jason, Creighton, Chad J., Kurie, Jonathan M.

“…Epithelial-to-mesenchymal transition (EMT) is a transcriptionally governed process by which cancer cells establish a front-rear polarity axis that facilitates…”
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A Pan-cancer Analysis of the Expression and Clinical Relevance of Small Nucleolar RNAs in Human Cancer by Gong, Jing, Li, Yajuan, Liu, Chun-jie, Xiang, Yu, Li, Chunlai, Ye, Youqiong, Zhang, Zhao, Hawke, David H., Park, Peter K., Diao, Lixia, Putkey, John A., Yang, Liuqing, Guo, An-Yuan, Lin, Chunru, Han, Leng

“…Increasing evidence has demonstrated that small nucleolar RNAs (snoRNAs) play important roles in tumorigenesis. We systematically investigated the expression…”
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The Genomic Landscape and Clinical Relevance of A-to-I RNA Editing in Human Cancers by Han, Leng, Diao, Lixia, Yu, Shuangxing, Xu, Xiaoyan, Li, Jie, Zhang, Rui, Yang, Yang, Werner, Henrica M.J., Eterovic, A. Karina, Yuan, Yuan, Li, Jun, Nair, Nikitha, Minelli, Rosalba, Tsang, Yiu Huen, Cheung, Lydia W.T., Jeong, Kang Jin, Roszik, Jason, Ju, Zhenlin, Woodman, Scott E., Lu, Yiling, Scott, Kenneth L., Li, Jin Billy, Mills, Gordon B., Liang, Han

“…Adenosine-to-inosine (A-to-I) RNA editing is a widespread post-transcriptional mechanism, but its genomic landscape and clinical relevance in cancer have not…”
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Comprehensive Characterization of Alternative Polyadenylation in Human Cancer by Xiang, Yu, Ye, Youqiong, Lou, Yanyan, Yang, Yang, Cai, Chunyan, Zhang, Zhao, Mills, Tingting, Chen, Ning-Yuan, Kim, Yoonjin, Muge Ozguc, Fatma, Diao, Lixia, Karmouty-Quintana, Harry, Xia, Yang, Kellems, Rodney E, Chen, Zheng, Blackburn, Michael R, Yoo, Seung-Hee, Shyu, Ann-Bin, Mills, Gordon B, Han, Leng

“…Alternative polyadenylation (APA) is emerging as a major post-transcriptional mechanism for gene regulation, and dysregulation of APA contributes to several…”
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An Epithelial―Mesenchymal Transition Gene Signature Predicts Resistance to EGFR and PI3K Inhibitors and Identifies Axl as a Therapeutic Target for Overcoming EGFR Inhibitor Resistance by AVERETT BYERS, Lauren, LIXIA DIAO, NILSSON, Monique B, GUDIKOTE, Jayanthi, TRAN, Hai, CARDNELL, Robert J. G, BEARSS, David J, WARNER, Steven L, FOULKS, Jason M, KANNER, Steven B, GANDHI, Varsha, KRETT, Nancy, JING WANG, ROSEN, Steven T, KIM, Edward S, HERBST, RoyS, BLUMENSCHEIN, George R, LEE, J. Jack, LIPPMAN, Scott M, KIAN ANG, K, MILLS, Gordon B, HONG, Waun K, WEINSTEIN, John N, SAINTIGNY, Pierre, WISTUBA, Ignacio I, COOMBES, Kevin R, MINNA, John D, HEYMACH, John V, GIRARD, Luc, PEYTON, Michael, LI SHEN, YOUHONG FAN, GIRI, Uma, TUMULA, Praveen K

“…Epithelial-mesenchymal transition (EMT) has been associated with metastatic spread and EGF receptor (EGFR) inhibitor resistance. We developed and validated a…”
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A pan-cancer proteomic perspective on The Cancer Genome Atlas by Akbani, Rehan, Ng, Patrick Kwok Shing, Werner, Henrica M. J., Shahmoradgoli, Maria, Zhang, Fan, Ju, Zhenlin, Liu, Wenbin, Yang, Ji-Yeon, Yoshihara, Kosuke, Li, Jun, Ling, Shiyun, Seviour, Elena G., Ram, Prahlad T., Minna, John D., Diao, Lixia, Tong, Pan, Heymach, John V., Hill, Steven M., Dondelinger, Frank, Städler, Nicolas, Byers, Lauren A., Meric-Bernstam, Funda, Weinstein, John N., Broom, Bradley M., Verhaak, Roeland G. W., Liang, Han, Mukherjee, Sach, Lu, Yiling, Mills, Gordon B.

“…Protein levels and function are poorly predicted by genomic and transcriptomic analysis of patient tumours. Therefore, direct study of the functional proteome…”
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Geraniin ameliorates streptozotocin-induced diabetic retinopathy in rats via modulating retinal inflammation and oxidative stress by Yu, Zhimin, LingWei, Gao, Qing, Diao, Lixia

“…Diabetic retinopathy (DR) is the major complication of diabetes, which causes acquired vision loss in the working-age group population. Here, we planned to…”
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