Search Results - "Diana, Patrizia"

Therapeutic Strategies To Counteract Antibiotic Resistance in MRSA Biofilm‐Associated Infections by Cascioferro, Stella, Carbone, Daniela, Parrino, Barbara, Pecoraro, Camilla, Giovannetti, Elisa, Cirrincione, Girolamo, Diana, Patrizia

“…Methicillin‐resistant Staphylococcus aureus (MRSA) has emerged as one of the leading causes of persistent human infections. This pathogen is widespread and is…”
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Recent Developments in the Inhibition of Bacterial Adhesion as Promising Anti-Virulence Strategy by Pecoraro, Camilla, Carbone, Daniela, Parrino, Barbara, Cascioferro, Stella, Diana, Patrizia

“…Infectious diseases caused by antimicrobial-resistant strains have become a serious threat to global health, with a high social and economic impact…”
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Synthetic small molecules as anti-biofilm agents in the struggle against antibiotic resistance by Parrino, Barbara, Schillaci, Domenico, Carnevale, Ilaria, Giovannetti, Elisa, Diana, Patrizia, Cirrincione, Girolamo, Cascioferro, Stella

“…Biofilm formation significantly contributes to microbial survival in hostile environments and it is currently considered a key virulence factor for pathogens…”
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New 1,2,4-Oxadiazole Nortopsentin Derivatives with Cytotoxic Activity by Cascioferro, Stella, Attanzio, Alessandro, Di Sarno, Veronica, Musella, Simona, Tesoriere, Luisa, Cirrincione, Girolamo, Diana, Patrizia, Parrino, Barbara

“…New analogs of nortopsentin, a natural 2,4-bis(3'-indolyl)imidazole alkaloid, in which the central imidazole ring of the natural lead was replaced by a…”
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A New Oxadiazole-Based Topsentin Derivative Modulates Cyclin-Dependent Kinase 1 Expression and Exerts Cytotoxic Effects on Pancreatic Cancer Cells by Pecoraro, Camilla, Parrino, Barbara, Cascioferro, Stella, Puerta, Adrian, Avan, Amir, Peters, Godefridus J, Diana, Patrizia, Giovannetti, Elisa, Carbone, Daniela

“…Pancreatic ductal adenocarcinoma (PDAC) is a highly lethal form of cancer characterized by drug resistance, urging new therapeutic strategies. In recent years,…”
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Discovery of the 3-Amino-1,2,4-triazine-Based Library as Selective PDK1 Inhibitors with Therapeutic Potential in Highly Aggressive Pancreatic Ductal Adenocarcinoma by Carbone, Daniela, De Franco, Michele, Pecoraro, Camilla, Bassani, Davide, Pavan, Matteo, Cascioferro, Stella, Parrino, Barbara, Cirrincione, Girolamo, Dall'Acqua, Stefano, Moro, Stefano, Gandin, Valentina, Diana, Patrizia

“…Pyruvate dehydrogenase kinases (PDKs) are serine/threonine kinases, that are directly involved in altered cancer cell metabolism, resulting in cancer…”
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PI3K/AKT/mTOR signaling transduction pathway and targeted therapies in cancer by Glaviano, Antonino, Foo, Aaron S C, Lam, Hiu Y, Yap, Kenneth C H, Jacot, William, Jones, Robert H, Eng, Huiyan, Nair, Madhumathy G, Makvandi, Pooyan, Geoerger, Birgit, Kulke, Matthew H, Baird, Richard D, Prabhu, Jyothi S, Carbone, Daniela, Pecoraro, Camilla, Teh, Daniel B L, Sethi, Gautam, Cavalieri, Vincenzo, Lin, Kevin H, Javidi-Sharifi, Nathalie R, Toska, Eneda, Davids, Matthew S, Brown, Jennifer R, Diana, Patrizia, Stebbing, Justin, Fruman, David A, Kumar, Alan P

“…The PI3K/AKT/mTOR (PAM) signaling pathway is a highly conserved signal transduction network in eukaryotic cells that promotes cell survival, cell growth, and…”
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3-(6-Phenylimidazo [2,1-b][1,3,4]thiadiazol-2-yl)-1H-Indole Derivatives as New Anticancer Agents in the Treatment of Pancreatic Ductal Adenocarcinoma by Cascioferro, Stella, Li Petri, Giovanna, Parrino, Barbara, El Hassouni, Btissame, Carbone, Daniela, Arizza, Vincenzo, Perricone, Ugo, Padova, Alessandro, Funel, Niccola, Peters, Godefridus J., Cirrincione, Girolamo, Giovannetti, Elisa, Diana, Patrizia

“…A new series of imidazo[2,1-b][1,3,4]thiadiazole derivatives was efficiently synthesized and screened for their in vitro antiproliferative activity on a panel…”
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Nortopsentins as Leads from Marine Organisms for Anticancer and Anti-Inflammatory Agent Development by Pecoraro, Camilla, Terrana, Francesca, Panzeca, Giovanna, Parrino, Barbara, Cascioferro, Stella, Diana, Patrizia, Giovannetti, Elisa, Carbone, Daniela

“…The marine environment is an excellent source of molecules that have a wide structural diversity and a variety of biological activities. Many marine natural…”
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Structural Manipulations of Marine Natural Products Inspire a New Library of 3-Amino-1,2,4-Triazine PDK Inhibitors Endowed with Antitumor Activity in Pancreatic Ductal Adenocarcinoma by Carbone, Daniela, De Franco, Michele, Pecoraro, Camilla, Bassani, Davide, Pavan, Matteo, Cascioferro, Stella, Parrino, Barbara, Cirrincione, Girolamo, Dall'Acqua, Stefano, Sut, Stefania, Moro, Stefano, Gandin, Valentina, Diana, Patrizia

“…Pancreatic ductal adenocarcinoma (PDAC) is one of the main aggressive types of cancer, characterized by late prognosis and drug resistance. Among the main…”
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Cyclin Dependent Kinase-1 (CDK-1) Inhibition as a Novel Therapeutic Strategy against Pancreatic Ductal Adenocarcinoma (PDAC) by Wijnen, Rosa, Pecoraro, Camilla, Carbone, Daniela, Fiuji, Hamid, Avan, Amir, Peters, Godefridus J., Giovannetti, Elisa, Diana, Patrizia

“…The role of CDK1 in PDAC onset and development is two-fold. Firstly, since CDK1 activity regulates the G2/M cell cycle checkpoint, overexpression of CDK1 can…”
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1,2,4‐Oxadiazole Topsentin Analogs with Antiproliferative Activity against Pancreatic Cancer Cells, Targeting GSK3β Kinase by Carbone, Daniela, Parrino, Barbara, Cascioferro, Stella, Pecoraro, Camilla, Giovannetti, Elisa, Di Sarno, Veronica, Musella, Simona, Auriemma, Giulia, Cirrincione, Girolamo, Diana, Patrizia

“…A new series of topsentin analogs, in which the central imidazole ring of the natural lead was replaced by a 1,2,4‐oxadiazole moiety, was efficiently…”
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1,3,4-Oxadiazole and 1,3,4-Thiadiazole Nortopsentin Derivatives against Pancreatic Ductal Adenocarcinoma: Synthesis, Cytotoxic Activity, and Inhibition of CDK1 by Carbone, Daniela, Pecoraro, Camilla, Panzeca, Giovanna, Xu, Geng, Roeten, Margot S F, Cascioferro, Stella, Giovannetti, Elisa, Diana, Patrizia, Parrino, Barbara

“…A new series of nortopsentin analogs, in which the central imidazole ring of the natural lead was replaced by a 1,3,4-oxadiazole or 1,3,4-thiadiazole moiety,…”
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Novel [1,3,4]Thiadiazole[3,2- a ]pyrimidin-5-ones as Promising Biofilm Dispersal Agents against Relevant Gram-Positive and Gram-Negative Pathogens by Carbone, Daniela, Pecoraro, Camilla, Scianò, Fabio, Catania, Valentina, Schillaci, Domenico, Manachini, Barbara, Cascioferro, Stella, Diana, Patrizia, Parrino, Barbara

“…Biofilm-associated infections pose significant challenges in healthcare settings due to their resistance to conventional antimicrobial therapies. In the last…”
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Interleukin 3- receptor targeted exosomes inhibit in vitro and in vivo Chronic Myelogenous Leukemia cell growth by Bellavia, Daniele, Raimondo, Stefania, Calabrese, Giovanna, Forte, Stefano, Cristaldi, Marta, Patinella, Agostina, Memeo, Lorenzo, Manno, Mauro, Raccosta, Samuele, Diana, Patrizia, Cirrincione, Girolamo, Giavaresi, Gianluca, Monteleone, Francesca, Fontana, Simona, De Leo, Giacomo, Alessandro, Riccardo

“…Despite Imatinib (IM), a selective inhibitor of Bcr-Abl, having led to improved prognosis in Chronic Myeloid Leukemia (CML) patients, acquired resistance and…”
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Multi or Single-Kinase Inhibitors to Counteract Drug Resistance in Cancer: What is New? by Pecoraro, Camilla, Carbone, Daniela, Cascioferro, Stella Maria, Parrino, Barbara, Diana, Patrizia

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Inhibitors of antibiotic resistance mechanisms: clinical applications and future perspectives by Parrino, Barbara, Carbone, Daniela, Cirrincione, Girolamo, Diana, Patrizia, Cascioferro, Stella

“…The biochemical mechanisms of antibiotic resistance such as enzymatic resistance, which causes the inactivation of the antibiotics and efflux pumps responsible…”
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Thiazole Analogues of the Marine Alkaloid Nortopsentin as Inhibitors of Bacterial Biofilm Formation by Carbone, Anna, Cascioferro, Stella, Parrino, Barbara, Carbone, Daniela, Pecoraro, Camilla, Schillaci, Domenico, Cusimano, Maria Grazia, Cirrincione, Girolamo, Diana, Patrizia

“…Anti-virulence strategy is currently considered a promising approach to overcome the global threat of the antibiotic resistance. Among different bacterial…”
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Nobiletin and xanthohumol counteract the TNFα‐mediated activation of endothelial cells through the inhibition of the NF‐κB signaling pathway by Corrado, Chiara, Barreca, Maria Magdalena, Raimondo, Stefania, Diana, Patrizia, Pepe, Giacomo, Basilicata, Maria Giovanna, Conigliaro, Alice, Alessandro, Riccardo

“…Angiogenesis, a process characterized by the formation of new blood vessels from pre‐existing ones, is a crucial step in tumor growth and dissemination. Given…”
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Synthesis and Antioxidative Properties of 1,2,3,4-Tetrahydropyridine Derivatives with Different Substituents in 4-Position by Aiello, Daniele, Jonas, Hendrik, Carbone, Anna, Carbone, Daniela, Pecoraro, Camilla, Tesoriere, Luisa, Köhler, Jens, Wünsch, Bernhard, Diana, Patrizia

“…Natural products are an excellent source of inspiration for the development of new drugs. Among them, betalains have been extensively studied for their…”
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