Search Results - "Diana, Donatella"

Switching the N-Capping Region from all-L to all-D Amino Acids in a VEGF Mimetic Helical Peptide by De Rosa, Lucia, Diana, Donatella, Capasso, Domenica, Stefania, Rachele, Di Stasi, Rossella, Fattorusso, Roberto, D’Andrea, Luca Domenico

“…The N-capping region of an α-helix is a short N-terminal amino acid stretch that contributes to nucleate and stabilize the helical structure. In the VEGF…”
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Structural characterization of PHOX2B and its DNA interaction shed light on the molecular basis of the +7Ala variant pathogenicity in CCHS by Diana, Donatella, Pirone, Luciano, Russo, Luigi, D'Abrosca, Gianluca, Madheswaran, Manoj, Benfante, Roberta, Di Lascio, Simona, Caldinelli, Laura, Fornasari, Diego, Acconcia, Clementina, Corvino, Andrea, Ventserova, Nataliia, Pollegioni, Loredano, Isernia, Carla, Di Gaetano, Sonia, Malgieri, Gaetano, Pedone, Emilia M, Fattorusso, Roberto

“…An expansion of poly-alanine up to +13 residues in the C-terminus of the transcription factor PHOX2B underlies the onset of congenital central hypoventilation…”
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SPR and NMR characterization of the molecular interaction between A9 peptide and a model system of HER2 receptor: A fragment approach for selecting peptide structures specific for their target by De Luca, Stefania, Verdoliva, Valentina, Saviano, Michele, Fattorusso, Roberto, Diana, Donatella

“…The binding process of A9 peptide toward HER2‐DIVMP, a synthetic model of the receptor domain IV, was studied by using the surface plasmon resonance (SPR)…”
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Cooperative Binding of the Cationic Porphyrin Tris-T4 Enhances Catalytic Activity of 20S Proteasome Unveiling a Complex Distribution of Functional States by Santoro, Anna Maria, D'Urso, Alessandro, Cunsolo, Alessandra, Milardi, Danilo, Purrello, Roberto, Sbardella, Diego, Tundo, Grazia R, Diana, Donatella, Fattorusso, Roberto, Dato, Antonio Di, Paladino, Antonella, Persico, Marco, Coletta, Massimo, Fattorusso, Caterina

“…The present study provides new evidence that cationic porphyrins may be considered as tunable platforms to interfere with the structural "key code" present on…”
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VEGFR Recognition Interface of a Proangiogenic VEGF‐Mimetic Peptide Determined In Vitro and in the Presence of Endothelial Cells by NMR Spectroscopy by Di Stasi, Rossella, Diana, Donatella, Capasso, Domenica, Di Gaetano, Sonia, De Rosa, Lucia, Celentano, Veronica, Isernia, Carla, Fattorusso, Roberto, D'Andrea, Luca D.

“…QK peptide is a vascular endothelial growth factor (VEGF)‐mimetic molecule with significant proangiogenic activity. In particular, QK is able to bind and…”
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Ligand-Based NMR Study of C‑X‑C Chemokine Receptor Type 4 (CXCR4)–Ligand Interactions on Living Cancer Cells by Brancaccio, Diego, Diana, Donatella, Di Maro, Salvatore, Di Leva, Francesco Saverio, Tomassi, Stefano, Fattorusso, Roberto, Russo, Luigi, Scala, Stefania, Trotta, Anna Maria, Portella, Luigi, Novellino, Ettore, Marinelli, Luciana, Carotenuto, Alfonso

“…Peptide-binding G protein-coupled receptors (GPCRs) are key effectors in numerous pathological and physiological pathways. The assessment of the receptor-bound…”
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Structural characterization of the thermal unfolding pathway of human VEGFR1 D2 domain by Diana, Donatella, Di Stasi, Rossella, García‐Viñuales, Sara, De Rosa, Lucia, Isernia, Carla, Malgieri, Gaetano, Milardi, Danilo, D’Andrea, Luca D., Fattorusso, Roberto

“…Folding stability is a crucial feature of protein evolution and is essential for protein functions. Thus, the comprehension of protein folding mechanisms…”
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Conformational stabilization of a β-hairpin through a triazole-tryptophan interaction by Diana, Donatella, Di Salvo, Claudia, Celentano, Veronica, De Rosa, Lucia, Romanelli, Alessandra, Fattorusso, Roberto, D'Andrea, Luca D

“…Molecular tools to stabilize the β-hairpin conformation are needed as β-hairpin peptides are useful molecules for pharmaceutical, biological and materials…”
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Biochemical and Conformational Characterization of Recombinant VEGFR2 Domain 7 by Di Stasi, Rossella, Diana, Donatella, De Rosa, Lucia, Fattorusso, Roberto, D’Andrea, Luca D.

“…Angiogenesis is a biological process finely tuned by a plethora of pro- and anti-angiogenic molecules, among which vascular endothelial growth factors (VEGFs)…”
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Modulation of the 20S Proteasome Activity by Porphyrin Derivatives Is Steered through Their Charge Distribution by Persico, Marco, Santoro, Anna Maria, D’Urso, Alessandro, Milardi, Danilo, Purrello, Roberto, Cunsolo, Alessandra, Gobbo, Marina, Fattorusso, Roberto, Diana, Donatella, Stefanelli, Manuela, Tundo, Grazia R., Sbardella, Diego, Coletta, Massimo, Fattorusso, Caterina

“…Cationic porphyrins exhibit an amazing variety of binding modes and inhibition mechanisms of 20S proteasome. Depending on the spatial distribution of their…”
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Human Recombinant VEGFR2D4 Biochemical Characterization to Investigate Novel Anti-VEGFR2D4 Antibodies for Allosteric Targeting of VEGFR2 by Di Stasi, Rossella, De Rosa, Lucia, Diana, Donatella, Fattorusso, Roberto, D’Andrea, Luca D.

“…VEGF-A/VEGFR2 complex is the major signaling pathway involved in angiogenesis and the inhibition of this axis retards tumor growth and inflammatory disorders…”
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A New Nerve Growth Factor-Mimetic Peptide Active on Neuropathic Pain in Rats by Colangelo, Anna Maria, Bianco, Maria Rosaria, Vitagliano, Luigi, Cavaliere, Carlo, Cirillo, Giovanni, De Gioia, Luca, Diana, Donatella, Colombo, Daniele, Redaelli, Cristina, Zaccaro, Laura, Morelli, Giancarlo, Papa, Michele, Sarmientos, Paolo, Alberghina, Lilia, Martegani, Enzo

“…Analysis of the structure of nerve growth factor (NGF)-tyrosine kinase receptor A (TrkA) complex, site-directed mutagenesis studies and results from chemical…”
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Neuroblastoma tumorigenesis is regulated through the Nm23-H1/h-Prune C-terminal interaction by Carotenuto, Marianeve, Pedone, Emilia, Diana, Donatella, de Antonellis, Pasqualino, Džeroski, Sašo, Marino, Natascia, Navas, Luigi, Di Dato, Valeria, Scoppettuolo, Maria Nunzia, Cimmino, Flora, Correale, Stefania, Pirone, Luciano, Monti, Simona Maria, Bruder, Elisabeth, Ženko, Bernard, Slavkov, Ivica, Pastorino, Fabio, Ponzoni, Mirco, Schulte, Johannes H., Schramm, Alexander, Eggert, Angelika, Westermann, Frank, Arrigoni, Gianluigi, Accordi, Benedetta, Basso, Giuseppe, Saviano, Michele, Fattorusso, Roberto, Zollo, Massimo

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Metabolic and conformational stabilization of a VEGF-mimetic beta-hairpin peptide by click-chemistry by De Rosa, Lucia, Capasso, Domenica, Diana, Donatella, Stefania, Rachele, Di Stasi, Rossella, Fattorusso, Roberto, D'Andrea, Luca Domenico

“…HPLW is a Vascular Endothelial Growth Factor (VEGF)-mimicking beta-hairpin peptide endowed of proangiogenic effect and showing valuable biomedical application…”
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Miniaturizing VEGF: Peptides mimicking the discontinuous VEGF receptor-binding site modulate the angiogenic response by De Rosa, Lucia, Finetti, Federica, Diana, Donatella, Di Stasi, Rossella, Auriemma, Sara, Romanelli, Alessandra, Fattorusso, Roberto, Ziche, Marina, Morbidelli, Lucia, D’Andrea, Luca Domenico

“…The angiogenic properties of VEGF are mediated through the binding of VEGF to its receptor VEGFR2. The VEGF/VEGFR interface is constituted by a discontinuous…”
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Unveiling a VEGF-mimetic peptide sequence in the IQGAP1 protein by Capasso, Domenica, Di Gaetano, Sonia, Celentano, Veronica, Diana, Donatella, Festa, Luisa, Di Stasi, Rossella, De Rosa, Lucia, Fattorusso, Roberto, D'Andrea, Luca D

“…The ability to modulate angiogenesis by chemical tools has several important applications in different scientific fields. With the perspective of finding novel…”
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DDDR-32. A NEW IMMUNOMODULATORY FUNCTION OF PYRIDO-PYRIMIDINE DERIVATIVES TO IMPAIR METASTATIC GROUP 3 MEDULLOBLASTOMA IN VIVO by Zollo, Massimo, Asadzadeh, Fatemeh, Ferrucci, Veronica, De Antonellis, Pasqualino, Bibbò, Francesca, Siciliano, Roberto, Sorice, Carmen, Criscuolo, Giuseppina, Filiz, Dalim Kardelen, Tecik, Melisa, Amente, Stefano, Saccà, Carmen Daniela, Gorini, Francesca, Pedone, Emilia, Diana, Donatella, Pirone, Luciano, Fattorusso, Roberto, Navas, Luigi, Donofrio, Vittoria, Errico, Maria Elena, Spennato, Pietro, De Martino, Lucia, Quaglietta, Lucia, Tirone, Felice, Cinalli, Giuseppe

“…Abstract Medulloblastoma (MB) is an embryonal tumor of the cerebellum constituting ~ 20% of pediatric brain tumors. To date, four MB molecular groups (further…”
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Functional Binding Surface of a β-Hairpin VEGF Receptor Targeting Peptide Determined by NMR Spectroscopy in Living Cells by Diana, Donatella, Russomanno, Anna, De Rosa, Lucia, Di Stasi, Rossella, Capasso, Domenica, Di Gaetano, Sonia, Romanelli, Alessandra, Russo, Luigi, D'Andrea, Luca D., Fattorusso, Roberto

“…In this study, the functional interaction of HPLW peptide with VEGFR2 (Vascular Endothelial Growth Factor Receptor 2) was determined by using fast 15N‐edited…”
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Insight into conformational modification of alpha-synuclein in the presence of neuronal whole cells and of their isolated membranes by Smaldone, Giovanni, Diana, Donatella, Pollegioni, Loredano, Di Gaetano, Sonia, Fattorusso, Roberto, Pedone, Emilia

“…•α-Syn interaction to SH-SY5Y cells is accompanied by an increase in α-helical content.•α-Syn N-terminus is involved in the interaction with membrane…”
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Probing the helical stability in a VEGF-mimetic peptide by De Rosa, Lucia, Diana, Donatella, Di Stasi, Rossella, Romanelli, Alessandra, Sciacca, Michele F.M., Milardi, Danilo, Isernia, Carla, Fattorusso, Roberto, D'Andrea, Luca D.

“…[Display omitted] •Helical content of QK peptide can be modulated replacing Leu10.•Replacing Leu10 with hydrophobic residues reduces QK thermal stability.•In…”
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