Search Results - "Diamond, Scott"

Systems Analysis of Thrombus Formation by Diamond, Scott L

“…The systems analysis of thrombosis seeks to quantitatively predict blood function in a given vascular wall and hemodynamic context. Relevant to both venous and…”
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Fibrin Modulates Shear-Induced NETosis in Sterile Occlusive Thrombi Formed under Haemodynamic Flow by Yu, Xinren, Diamond, Scott L

“…Neutrophils can release extracellular traps (NETs) in infectious, inflammatory and thrombotic diseases. NETs have been detected in deep vein thrombosis,…”
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Platelet Dynamics in Three-Dimensional Simulation of Whole Blood by Vahidkhah, Koohyar, Diamond, Scott L., Bagchi, Prosenjit

“…A high-fidelity computational model using a 3D immersed boundary method is used to study platelet dynamics in whole blood. We focus on the 3D effects of the…”
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Reduced model to predict thrombin and fibrin during thrombosis on collagen/tissue factor under venous flow: Roles of γ'-fibrin and factor XIa by Chen, Jason, Diamond, Scott L

“…During thrombosis, thrombin generates fibrin, however fibrin reversibly binds thrombin with low affinity E-domain sites (KD = 2.8 μM) and high affinity…”
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Sensitivity analysis of a reduced model of thrombosis under flow: Roles of Factor IX, Factor XI, and γ'-Fibrin by Chen, Jason, Diamond, Scott L

“…A highly reduced extrinsic pathway coagulation model (8 ODEs) under flow considered a thin 15-micron platelet layer where transport limitations were largely…”
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A human platelet calcium calculator trained by pairwise agonist scanning by Lee, Mei Yan, Diamond, Scott L

“…Since platelet intracellular calcium mobilization [Ca(t)]i controls granule release, cyclooxygenase-1 and integrin activation, and phosphatidylserine exposure,…”
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Predicting risk for trauma patients using static and dynamic information from the MIMIC III database by Tsiklidis, Evan J, Sinno, Talid, Diamond, Scott L

“…Risk quantification algorithms in the ICU can provide (1) an early alert to the clinician that a patient is at extreme risk and (2) help manage limited…”
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Establishing the Transient Mass Balance of Thrombosis: From Tissue Factor to Thrombin to Fibrin Under Venous Flow by Zhu, Shu, Chen, Jason, Diamond, Scott L

“…OBJECTIVE—We investigated the coregulation of thrombin and fibrin as blood flows over a procoagulant surface. APPROACH AND RESULTS—Using microfluidic perfusion…”
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Using the National Trauma Data Bank (NTDB) and machine learning to predict trauma patient mortality at admission by Tsiklidis, Evan J, Sims, Carrie, Sinno, Talid, Diamond, Scott L

“…A 400-estimator gradient boosting classifier was trained to predict survival probabilities of trauma patients. The National Trauma Data Bank (NTDB) provided…”
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Hierarchical organization in the hemostatic response and its relationship to the platelet-signaling network by Stalker, Timothy J., Traxler, Elizabeth A., Wu, Jie, Wannemacher, Kenneth M., Cermignano, Samantha L., Voronov, Roman, Diamond, Scott L., Brass, Lawrence F.

“…Achieving hemostasis following vascular injury requires the rapid accumulation of platelets and fibrin. Here we used a combination of confocal intravital…”
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A three-dimensional multiscale model for the prediction of thrombus growth under flow with single-platelet resolution by Shankar, Kaushik N, Zhang, Yiyuan, Sinno, Talid, Diamond, Scott L

“…Modeling thrombus growth in pathological flows allows evaluation of risk under patient-specific pharmacological, hematological, and hemodynamical conditions…”
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Investigating thrombin-loaded fibrin in whole blood clot microfluidic assay via fluorogenic peptide by Crossen, Jennifer, Shankar, Kaushik N., Diamond, Scott L.

“…During clotting under flow, thrombin rapidly generates fibrin, whereas fibrin potently sequesters thrombin. This co-regulation was studied using microfluidic…”
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When Flow Goes Slow, von Willebrand Factor Can Bind Red Blood Cells by Diamond, Scott L

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Contact activation of blood coagulation on a defined kaolin/collagen surface in a microfluidic assay by Zhu, Shu, Diamond, Scott L

“…Abstract Generation of active Factor XII (FXIIa) triggers blood clotting on artificial surfaces and may also enhance intravascular thrombosis. We developed a…”
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Ex vivo recapitulation of trauma-induced coagulopathy and preliminary assessment of trauma patient platelet function under flow using microfluidic technology by Li, Ruizhi, Elmongy, Hanna, Sims, Carrie, Diamond, Scott L

“…Relevant to trauma-induced coagulopathy diagnostics, microfluidic assays allow controlled hemodynamics for testing of platelet and coagulation function using…”
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Systems biology of coagulation initiation: kinetics of thrombin generation in resting and activated human blood by Chatterjee, Manash S, Denney, William S, Jing, Huiyan, Diamond, Scott L

“…Blood function defines bleeding and clotting risks and dictates approaches for clinical intervention. Independent of adding exogenous tissue factor (TF), human…”
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Direct Observation of von Willebrand Factor Elongation and Fiber Formation on Collagen During Acute Whole Blood Exposure to Pathological Flow by Colace, Thomas V, Diamond, Scott L

“…OBJECTIVE—In severe stenosis, von Willebrand Factor (vWF) experiences millisecond exposures to pathological wall shear rates (γw). We sought to evaluate the…”
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Blood Clots Are Rapidly Assembled Hemodynamic Sensors: Flow Arrest Triggers Intraluminal Thrombus Contraction by Muthard, Ryan W, Diamond, Scott L

“…OBJECTIVE—Blood clots form under flow during intravascular thrombosis or vessel leakage. Prevailing hemodynamics influence thrombus structure and may regulate…”
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FXIa and platelet polyphosphate as therapeutic targets during human blood clotting on collagen/tissue factor surfaces under flow by Zhu, Shu, Travers, Richard J., Morrissey, James H., Diamond, Scott L.

“…Factor XIIa (FXIIa) and factor XIa (FXIa) contribute to thrombosis in animal models, whereas platelet-derived polyphosphate (polyP) may potentiate contact or…”
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Platelet dysfunction during trauma involves diverse signaling pathways and an inhibitory activity in patient-derived plasma by Verni, Christopher C, Davila, Jr, Antonio, Balian, Steve, Sims, Carrie A, Diamond, Scott L

“…Trauma-induced coagulopathy occurs in about 25% of injured patients and accounts for about 10% of deaths worldwide. Upon injury, hemostatic function may…”
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