Search Results - "Diamond, Michael S."

Innate immunity: the first line of defense against SARS-CoV-2 by Diamond, Michael S., Kanneganti, Thirumala-Devi

“…The coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute respiratory syndrome coronavirus (SARS-CoV)-2, continues to cause substantial…”
Get full text

Shared and Distinct Functions of Type I and Type III Interferons by Lazear, Helen M., Schoggins, John W., Diamond, Michael S.

“…Type I interferons (IFNs) (IFN-α, IFN-β) and type III IFNs (IFN-λ) share many properties, including induction by viral infection, activation of shared…”
Get full text

The broad-spectrum antiviral functions of IFIT and IFITM proteins by Diamond, Michael S., Farzan, Michael

“…Key Points IFN-induced protein with tetratricopeptide repeats (IFIT) proteins — which are induced after type I interferon (IFN)- or IFN-regulatory factor 3…”
Get full text

Zika Virus: New Clinical Syndromes and Its Emergence in the Western Hemisphere by Lazear, Helen M, Diamond, Michael S

“…Zika virus (ZIKV) had remained a relatively obscure flavivirus until a recent series of outbreaks accompanied by unexpectedly severe clinical complications…”
Get full text

The continued threat of emerging flaviviruses by Pierson, Theodore C., Diamond, Michael S.

“…Flaviviruses are vector-borne RNA viruses that can emerge unexpectedly in human populations and cause a spectrum of potentially severe diseases including…”
Get full text

Animal Models of Zika Virus Infection, Pathogenesis, and Immunity by Morrison, Thomas E, Diamond, Michael S

“…Zika virus (ZIKV) is an emerging mosquito-transmitted flavivirus that now causes epidemics affecting millions of people on multiple continents. The virus has…”
Get full text

Molecular Insight into Dengue Virus Pathogenesis and Its Implications for Disease Control by Diamond, Michael S., Pierson, Theodore C.

“…Dengue virus (DENV) is a mosquito-transmitted RNA virus that infects an estimated 390 million humans each year. Here, we review recent advances in our…”
Get full text

Interferon-λ: Immune Functions at Barrier Surfaces and Beyond by Lazear, Helen M., Nice, Timothy J., Diamond, Michael S.

“…When type III interferon (IFN-λ; also known as interleukin-28 [IL-28] and IL-29) was discovered in 2003, its antiviral function was expected to be analogous to…”
Get full text

Limited Regional Aerosol and Cloud Microphysical Changes Despite Unprecedented Decline in Nitrogen Oxide Pollution During the February 2020 COVID‐19 Shutdown in China by Diamond, Michael S., Wood, Robert

“…Following the emergence of a novel coronavirus in Wuhan, China instituted shutdown measures starting in late January and continuing into February 2020 to…”
Get full text

Zika Virus Infection during Pregnancy in Mice Causes Placental Damage and Fetal Demise by Miner, Jonathan J., Cao, Bin, Govero, Jennifer, Smith, Amber M., Fernandez, Estefania, Cabrera, Omar H., Garber, Charise, Noll, Michelle, Klein, Robyn S., Noguchi, Kevin K., Mysorekar, Indira U., Diamond, Michael S.

“…Zika virus (ZIKV) infection in pregnant women causes intrauterine growth restriction, spontaneous abortion, and microcephaly. Here, we describe two mouse…”
Get full text

An infectious SARS-CoV-2 B.1.1.529 Omicron virus escapes neutralization by therapeutic monoclonal antibodies by VanBlargan, Laura A., Errico, John M., Halfmann, Peter J., Zost, Seth J., Crowe, James E., Purcell, Lisa A., Kawaoka, Yoshihiro, Corti, Davide, Fremont, Daved H., Diamond, Michael S.

“…The emergence of the highly transmissible B.1.1.529 Omicron variant of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is concerning for antibody…”
Get full text

After the pandemic: perspectives on the future trajectory of COVID-19 by Telenti, Amalio, Arvin, Ann, Corey, Lawrence, Corti, Davide, Diamond, Michael S., García-Sastre, Adolfo, Garry, Robert F., Holmes, Edward C., Pang, Phillip S., Virgin, Herbert W.

“…There is a realistic expectation that the global effort in vaccination will bring the pandemic caused by severe acute respiratory syndrome coronavirus 2…”
Get full text

A Mouse Model of Zika Virus Pathogenesis by Lazear, Helen M., Govero, Jennifer, Smith, Amber M., Platt, Derek J., Fernandez, Estefania, Miner, Jonathan J., Diamond, Michael S.

“…The ongoing Zika virus (ZIKV) epidemic and unexpected clinical outcomes, including Guillain-Barré syndrome and birth defects, has brought an urgent need for…”
Get full text

De novo design of picomolar SARS-CoV-2 miniprotein inhibitors by Cao, Longxing, Goreshnik, Inna, Coventry, Brian, Case, James Brett, Miller, Lauren, Kozodoy, Lisa, Chen, Rita E, Carter, Lauren, Walls, Alexandra C, Park, Young-Jun, Strauch, Eva-Maria, Stewart, Lance, Diamond, Michael S, Veesler, David, Baker, David

“…Targeting the interaction between the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike protein and the human angiotensin-converting enzyme 2…”
Get full text

Cross-neutralization of SARS-CoV-2 by a human monoclonal SARS-CoV antibody by Pinto, Dora, Park, Young-Jun, Beltramello, Martina, Walls, Alexandra C., Tortorici, M. Alejandra, Bianchi, Siro, Jaconi, Stefano, Culap, Katja, Zatta, Fabrizia, De Marco, Anna, Peter, Alessia, Guarino, Barbara, Spreafico, Roberto, Cameroni, Elisabetta, Case, James Brett, Chen, Rita E., Havenar-Daughton, Colin, Snell, Gyorgy, Telenti, Amalio, Virgin, Herbert W., Lanzavecchia, Antonio, Diamond, Michael S., Fink, Katja, Veesler, David, Corti, Davide

“…Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a newly emerged coronavirus that is responsible for the current pandemic of coronavirus disease…”
Get full text

Inhibition of autophagy limits vertical transmission of Zika virus in pregnant mice by Cao, Bin, Parnell, Lindsay A, Diamond, Michael S, Mysorekar, Indira U

“…Zika virus (ZIKV) infection during pregnancy leads to devastating fetal outcomes, including intrauterine growth restriction and microcephaly. Greater…”
Get full text

A Crisp(r) New Perspective on SARS-CoV-2 Biology by Bailey, Adam L., Diamond, Michael S.

“…Complementary genome-wide CRISPR-Cas9 screens performed by multiple groups reveal new insights into SARS-CoV-2 biology including aspects of viral entry,…”
Get full text

SARS-CoV-2 infection of human ACE2-transgenic mice causes severe lung inflammation and impaired function by Winkler, Emma S., Bailey, Adam L., Kafai, Natasha M., Nair, Sharmila, McCune, Broc T., Yu, Jinsheng, Fox, Julie M., Chen, Rita E., Earnest, James T., Keeler, Shamus P., Ritter, Jon H., Kang, Liang-I, Dort, Sarah, Robichaud, Annette, Head, Richard, Holtzman, Michael J., Diamond, Michael S.

“…Although animal models have been evaluated for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, none have fully recapitulated the lung…”
Get full text

Growth, detection, quantification, and inactivation of SARS-CoV-2 by Case, James Brett, Bailey, Adam L., Kim, Arthur S., Chen, Rita E., Diamond, Michael S.

“…Severe acute respiratory syndrome coronavirus (SARS-CoV)-2 is the agent responsible for the coronavirus disease 2019 (COVID-19) global pandemic. SARS-CoV-2 is…”
Get full text

Mechanisms of restriction of viral neuroinvasion at the blood–brain barrier by Miner, Jonathan J, Diamond, Michael S

“…Highlights • Neurotropic viruses invade the CNS via several routes including direct transit across the blood–brain barrier (BBB). • Pro-inflammatory cytokines…”
Get full text