Search Results - "Diamond, Marc I."

Propagation of Protein Aggregation in Neurodegenerative Diseases by Vaquer-Alicea, Jaime, Diamond, Marc I

“…Most common neurodegenerative diseases feature deposition of protein amyloids and degeneration of brain networks. Amyloids are ordered protein assemblies that…”
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Distinct Tau Prion Strains Propagate in Cells and Mice and Define Different Tauopathies by Sanders, David W., Kaufman, Sarah K., DeVos, Sarah L., Sharma, Apurwa M., Mirbaha, Hilda, Li, Aimin, Barker, Scarlett J., Foley, Alex C., Thorpe, Julian R., Serpell, Louise C., Miller, Timothy M., Grinberg, Lea T., Seeley, William W., Diamond, Marc I.

“…Prion-like propagation of tau aggregation might underlie the stereotyped progression of neurodegenerative tauopathies. True prions stably maintain unique…”
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Tau strains shape disease by Vaquer-Alicea, Jaime, Diamond, Marc I., Joachimiak, Lukasz A.

“…Tauopathies consist of over 25 different neurodegenerative diseases that include argyrophilic grain disease (AGD), progressive supranuclear palsy (PSP),…”
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Prion-like Properties of Tau Protein: The Importance of Extracellular Tau as a Therapeutic Target by Holmes, Brandon B., Diamond, Marc I.

“…Work over the past 4 years indicates that multiple proteins associated with neurodegenerative diseases, especially Tau and α-synuclein, can propagate…”
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Tau seeding activity begins in the transentorhinal/entorhinal regions and anticipates phospho-tau pathology in Alzheimer’s disease and PART by Kaufman, Sarah K., Del Tredici, Kelly, Thomas, Talitha L., Braak, Heiko, Diamond, Marc I.

“…Alzheimer’s disease (AD) is characterized by accumulation of tau neurofibrillary tangles (NFTs) and, according to the prion model, transcellular propagation of…”
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Anti-Tau Antibodies that Block Tau Aggregate Seeding In Vitro Markedly Decrease Pathology and Improve Cognition In Vivo by Yanamandra, Kiran, Kfoury, Najla, Jiang, Hong, Mahan, Thomas E., Ma, Shengmei, Maloney, Susan E., Wozniak, David F., Diamond, Marc I., Holtzman, David M.

“…Tau aggregation occurs in neurodegenerative diseases including Alzheimer’s disease and many other disorders collectively termed tauopathies. trans-cellular…”
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Propagation of Tau Misfolding from the Outside to the Inside of a Cell by Frost, Bess, Jacks, Rachel L., Diamond, Marc I.

“…Tauopathies are neurodegenerative diseases characterized by aggregation of the microtubule-associated protein Tau in neurons and glia. Although Tau is normally…”
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Trans-cellular Propagation of Tau Aggregation by Fibrillar Species by Kfoury, Najla, Holmes, Brandon B., Jiang, Hong, Holtzman, David M., Diamond, Marc I.

“…Aggregation of the microtubule associated protein Tau is associated with several neurodegenerative disorders, including Alzheimer disease and frontotemporal…”
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The prion model for progression and diversity of neurodegenerative diseases by Stopschinski, Barbara E, MD, Diamond, Marc I, Dr

“…Summary The neuropathology of different neurodegenerative diseases begins in different brain regions, and involves distinct brain networks. Evidence indicates…”
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Tau Prion Strains Dictate Patterns of Cell Pathology, Progression Rate, and Regional Vulnerability In Vivo by Kaufman, Sarah K., Sanders, David W., Thomas, Talitha L., Ruchinskas, Allison J., Vaquer-Alicea, Jaime, Sharma, Apurwa M., Miller, Timothy M., Diamond, Marc I.

“…Tauopathies are neurodegenerative disorders that affect distinct brain regions, progress at different rates, and exhibit specific patterns of tau accumulation…”
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Tau Trimers Are the Minimal Propagation Unit Spontaneously Internalized to Seed Intracellular Aggregation by Mirbaha, Hilda, Holmes, Brandon B., Sanders, David W., Bieschke, Jan, Diamond, Marc I.

“…Tau amyloid assemblies propagate aggregation from the outside to the inside of a cell, which may mediate progression of the tauopathies. The critical size of…”
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Proteopathic tau seeding predicts tauopathy in vivo by Holmes, Brandon B, Furman, Jennifer L, Mahan, Thomas E, Yamasaki, Tritia R, Mirbaha, Hilda, Eades, William C, Belaygorod, Larisa, Cairns, Nigel J, Holtzman, David M, Diamond, Marc I

“…Transcellular propagation of protein aggregates, or proteopathic seeds, may drive the progression of neurodegenerative diseases in a prion-like manner. In…”
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Network of hotspot interactions cluster tau amyloid folds by Mullapudi, Vishruth, Vaquer-Alicea, Jaime, Bommareddy, Vaibhav, Vega, Anthony R., Ryder, Bryan D., White, Charles L., Diamond, Marc. I., Joachimiak, Lukasz A.

“…Cryogenic electron microscopy has revealed unprecedented molecular insight into the conformations of β-sheet-rich protein amyloids linked to neurodegenerative…”
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Neuronal activity enhances tau propagation and tau pathology in vivo by Wu, Jessica W, Hussaini, S Abid, Bastille, Isle M, Rodriguez, Gustavo A, Mrejeru, Ana, Rilett, Kelly, Sanders, David W, Cook, Casey, Fu, Hongjun, Boonen, Rick A C M, Herman, Mathieu, Nahmani, Eden, Emrani, Sheina, Figueroa, Y Helen, Diamond, Marc I, Clelland, Catherine L, Wray, Selina, Duff, Karen E

“…The authors show that tau can be released by neurons and transferred to other neurons via the extracellular space. Moreover, they show that enhancing neuronal…”
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Heparan sulfate proteoglycans mediate internalization and propagation of specific proteopathic seeds by Holmes, Brandon B, DeVos, Sarah L, Kfoury, Najla, Li, Mei, Jacks, Rachel, Yanamandra, Kiran, Ouidja, Mohand O, Brodsky, Frances M, Marasa, Jayne, Bagchi, Devika P, Kotzbauer, Paul T, Miller, Timothy M, Papy-Garcia, Dulce, Diamond, Marc I

“…Recent experimental evidence suggests that transcellular propagation of fibrillar protein aggregates drives the progression of neurodegenerative diseases in a…”
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Profilin reduces aggregation and phase separation of huntingtin N-terminal fragments by preferentially binding to soluble monomers and oligomers by Posey, Ammon E., Ruff, Kiersten M., Harmon, Tyler S., Crick, Scott L., Li, Aimin, Diamond, Marc I., Pappu, Rohit V.

“…Huntingtin N-terminal fragments (Htt-NTFs) with expanded polyglutamine tracts form a range of neurotoxic aggregates that are associated with Huntington’s…”
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Mechanisms of protein seeding in neurodegenerative diseases by Walker, Lary C, Diamond, Marc I, Duff, Karen E, Hyman, Bradley T

“…Most age-associated neurodegenerative diseases involve the aggregation of specific proteins within the nervous system. In Alzheimer disease, the insidious…”
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Tau local structure shields an amyloid-forming motif and controls aggregation propensity by Chen, Dailu, Drombosky, Kenneth W., Hou, Zhiqiang, Sari, Levent, Kashmer, Omar M., Ryder, Bryan D., Perez, Valerie A., Woodard, DaNae R., Lin, Milo M., Diamond, Marc I., Joachimiak, Lukasz A.

“…Tauopathies are neurodegenerative diseases characterized by intracellular amyloid deposits of tau protein. Missense mutations in the tau gene ( MAPT )…”
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Ultrasensitive and selective detection of 3-repeat tau seeding activity in Pick disease brain and cerebrospinal fluid by Saijo, Eri, Ghetti, Bernardino, Zanusso, Gianluigi, Oblak, Adrian, Furman, Jennifer L., Diamond, Marc I., Kraus, Allison, Caughey, Byron

“…The diagnosis and treatment of diseases involving tau-based pathology such as Alzheimer disease and certain frontotemporal dementias is hampered by the…”
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Inert and seed-competent tau monomers suggest structural origins of aggregation by Mirbaha, Hilda, Chen, Dailu, Morazova, Olga A, Ruff, Kiersten M, Sharma, Apurwa M, Liu, Xiaohua, Goodarzi, Mohammad, Pappu, Rohit V, Colby, David W, Mirzaei, Hamid, Joachimiak, Lukasz A, Diamond, Marc I

“…Tauopathies feature progressive accumulation of tau amyloids. Pathology may begin when these amplify from a protein template, or seed, whose structure is…”
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