Biosynthesis of pure hematite phase magnetic iron oxide nanoparticles using floral extracts of Callistemon viminalis (bottlebrush): their physical properties and novel biological applications

Aqueous floral extracts of Callistemon viminalis were used to synthesize Fe O nanoparticles (IONPs) which were intensively characterized through UV-vis, X-ray diffraction, HR-SEM/HR-TEM, Fourier- transform infrared spectroscopy (FTIR) and energy dispersive X-ray spectroscopy (EDS). Their physical pr...

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Bibliographic Details
Published in:	Artificial cells, nanomedicine, and biotechnology Vol. 46; no. sup1; p. 693
Main Authors:	Hassan, Dilawar, Khalil, Ali Talha, Saleem, Jabran, Diallo, Abdullah, Khamlich, Saleh, Shinwari, Zabta Khan, Maaza, Malik
Format:	Journal Article
Language:	English
Published:	England 01-01-2018
Subjects:	Anti-Bacterial Agents - chemical synthesis Anti-Bacterial Agents - chemistry Anti-Bacterial Agents - pharmacology Antineoplastic Agents - chemical synthesis Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacology Antioxidants - chemical synthesis Antioxidants - chemistry Antioxidants - pharmacology Antiprotozoal Agents - chemical synthesis Antiprotozoal Agents - chemistry Antiprotozoal Agents - pharmacology Chemistry Techniques, Synthetic Cholinesterase Inhibitors - chemical synthesis Cholinesterase Inhibitors - chemistry Cholinesterase Inhibitors - pharmacology Erythrocytes - cytology Erythrocytes - drug effects Ferric Compounds - chemical synthesis Ferric Compounds - chemistry Ferric Compounds - pharmacology Flowers - chemistry Hep G2 Cells Humans Magnets - chemistry Materials Testing Myrtaceae - chemistry Particle Size Physical Phenomena Plant Extracts - chemistry Temperature antileishmanial nanoparticles DPPH biocompatibility Iron oxide (FeO) HepG2 temperature magnetic antibacterial hematite anti-cancer hepatocellular carcinoma
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Summary:	Aqueous floral extracts of Callistemon viminalis were used to synthesize Fe O nanoparticles (IONPs) which were intensively characterized through UV-vis, X-ray diffraction, HR-SEM/HR-TEM, Fourier- transform infrared spectroscopy (FTIR) and energy dispersive X-ray spectroscopy (EDS). Their physical properties were studied in response to different annealing temperatures. It was observed that the increase in the annealing temperature produced small-sized nanoparticles. The nanoparticle size was calculated as 32, 26 and 22 nm for annealing at 300, 400 and 500 °C, respectively. The magnetic nature of the bioinspired IONPs was revealed by superconducting quantum interference device (SQUID). Their antibacterial potential was investigated against nine pathogenic bacterial strains (gram positive and gram negative) using disc diffusion method while their MIC was calculated using broth dilution assay. Bioinspired IONPs were found to be highly effective against HepG2 cells (IC =20 µg/mL). Moderate antileishmanial activities against the promastigotes and amastigotes cultures are reported. Moderate acetylcholine esterase (AchE), butylcholine esterase (BchE) and α-Glycosidase inhibition are reported. Additional assessment of the biocompatibility was performed using haemolytic activity on the freshly isolated human red blood cells and macrophages. Furthermore, the antioxidant activities, including TAC, DPPH and TRP were also performed. Our results indicate that the biogenic and magnetic Fe O can be used for diverse biomedical applications.
ISSN:	2169-141X
DOI:	10.1080/21691401.2018.1434534