Search Results - "Diakos, C."

Immunogenic cell death in colorectal cancer: a review of mechanisms and clinical utility by De Silva, M., Tse, B. C. Y., Diakos, C. I., Clarke, S., Molloy, M. P.

“…Colorectal cancer (CRC) is a major cause of cancer-related morbidity and mortality worldwide. Despite several clinical advances the survival of patients with…”
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Cost of treating metastatic colorectal cancer: a systematic review by Bhimani, N., Wong, G.Y.M., Molloy, C., Pavlakis, N., Diakos, C.I., Clarke, S.J., Dieng, M., Hugh, T.J.

“…The cost of treating metastatic colorectal cancer places a significant economic burden on individuals, populations, and health care. However, there is a…”
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Retrospective cohort analysis of neoadjuvant treatment and survival in resectable and borderline resectable pancreatic ductal adenocarcinoma in a high volume referral centre by Itchins, M., Arena, J., Nahm, C.B., Rabindran, J., Kim, S., Gibbs, E., Bergamin, S., Chua, T.C., Gill, A.J., Maher, R., Diakos, C., Wong, M., Mittal, A., Hruby, G., Kneebone, A., Pavlakis, N., Samra, J., Clarke, S.

“…Pancreatic ductal adenocarcinoma (PDAC) is a deadly disease. Neoadjuvant therapy (NA) with chemotherapy (NAC) and radiotherapy (RT) prior to surgery provides…”
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Anti‐inflammatory effects of sodium butyrate on human monocytes: potent inhibition of IL‐12 and up‐regulation of IL‐10 production by Säemann, Marcus D., Böhmig, Georg A., Österreicher, Christoph H., Burtscher, Helmut, Parolini, Ornella, Diakos, Christos, Stöckl, Johannes, Hörl, Walter H., Zlabinger, Gerhard J.

“…ABSTRACT Cytokines are critical in regulating unresponsiveness versus immunity towards enteric antigens derived from the intestinal flora and ingested food…”
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Cytokines, chemokines and gene expresion patterns in BAL fluid of children after stem cell transplantation by Fazekas, T, Matthes, S, Lawitschka, A, Attarbaschi, A, Diakos, C, Eickhoff, P, Gadner, H, Fritsch, G, Peters, C

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Structure, Stability, and Interconversion Barriers of the Rotamers of cis-[PtIICl2(quinoline)2] and cis-[PtIICl2(3-bromoquinoline)(quinoline)] from X-ray Crystallography, NMR Spectroscopy and Molecular Mechanics Evidence by Davies, Murray S, Diakos, Connie I, Messerle, Barbara A, Hambley, Trevor W

“…Reported are the preparations of cis-[PtCl2(quinoline)2] and cis-[PtCl2(3-bromoquinoline)(quinoline)] and an investigation of the stabilities and…”
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P04.18 Unravelling the tumour microenvironment of glioma by McKelvey, K, Hudson, A, Wheeler, H, Diakos, C, Howell, V

“…Abstract Background With the incidence and mortality of brain cancer almost equivocal there is a vital need to understand the intricacies of the glioma…”
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DNA adducts of the enantiomers of the Pt(II) complexes of the ahaz ligand (ahaz = 3-aminohexahydroazepine) and recognition of these adducts by HMG domain proteins by Malina, Jaroslav, Vojtiskova, Marie, Brabec, Viktor, Diakos, Connie I., Hambley, Trevor W.

“…The bending, unwinding, and structural changes in DNA caused by the binding of each of the enantiomers of the platinum(II) complexes of the ahaz ligand ( R-…”
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Selective inhibition of NF-AT DNA binding by the short-chain fatty acid n-butyrate by Diakos, C, Prieschl, E, Säemann, M, Böhmig, G, Baumruker, T, Zlabinger, G

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Is baseline neutrophil to lymphocyte ratio (NLR) an independent prognostic biomarker for progression free survival (PFS) and overall survival (OS) in metastatic colorectal cancer (mCRC)? Analysis of the AGITG MAX study by Diakos, C.I., Wilson, K., Asher, R., Gebski, V., Yip, S., van Hazel, G., Robinson, B., Broad, A., Price, T.J., Simes, J., Tebbutt, N., Clarke, S.

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Modulation of primary T cell responses and tolerance induction by tyrphostin AG490 by Säemann, M.D, Diakos, C, Staffler, G, Böhmig, G.A, Österreicher, C.H, Stockinger, H, Zlabinger, G.J

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Is the derived neutrophil to lymphocyte ratio (dNLR) an independent prognostic marker in patients with metastatic colorectal cancer (mCRC)? Analysis of the CO.17 and CO.20 studies by Diakos, C.I., Tu, D., Gebski, V., Yip, S., Wilson, K., Karapetis, C.S., O'Callaghan, C.J., Shapiro, J., Tebbutt, N., Jonker, D.J., Siu, L.L., Wong, R., Doyle, C., Strickland, A.H., Price, T.J., Simes, J., Clarke, S.

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n-Butyrate inhibits Jun NH(2)-terminal kinase activation and cytokine transcription in mast cells by Diakos, Christos, Prieschl, Eva E., Säemann, Marcus D., Böhmig, Georg A., Csonga, Robert, Sobanov, Yury, Baumruker, Thomas, Zlabinger, Gerhard J.

“…Mast cells are well known to contribute to type I allergic conditions but only recently have been brought in association with chronic relapsing/remitting…”
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Prevention of CD40‐Triggered Dendritic Cell Maturation and Induction of T‐Cell Hyporeactivity by Targeting of Janus Kinase 3 by Säemann, Marcus D., Diakos, Christos, Kelemen, Peter, Kriehuber, Ernst, Zeyda, Maximilian, Böhmig, Georg A., Hörl, Walter H., Baumruker, Thomas, Zlabinger, Gerhard J.

“…Pharmacological targeting of Janus kinase 3 (JAK3) has been employed successfully to control allograft rejection and graft‐vs.‐host disease (GVHD). Recent…”
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Suppression of early T-cell-receptor-triggered cellular activation by the Janus kinase 3 inhibitor WHI-P-154 by Säemann, Marcus D, Zeyda, Maximilian, Diakos, Christos, Szekeres, Andreas, Böhmig, Georg A, Kelemen, Peter, Parolini, Ornella, Stockinger, Hannes, Prieschl, Eva E, Stulnig, Thomas M, Baumruker, Thomas, Zlabinger, Gerhard J

“…Therapeutic targeting of Janus kinase 3 (JAK3) has received particular attention, because it is associated with the common gamma signaling of cytokine…”
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Bacterial metabolite interference with maturation of human monocyte-derived dendritic cells by Säemann, Marcus D., Parolini, Ornella, Böhmig, Georg A., Kelemen, Peter, Krieger, Peter‐Michael, Neumüller, Josef, Knarr, Katharina, Kammlander, Willibald, Hörl, Walter H., Diakos, Christos, Stuhlmeier, Karl, Zlabinger, Gerhard J.

“…Dendritic cells (DC), the most potent APC, are central to antimicrobial immunity. Because of evolutionary pressure, it is reasonable that pathogens have…”
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Novel mode of interference with nuclear factor of activated T-cells regulation in T-cells by the bacterial metabolite n-butyrate by Diakos, Christos, Prieschl, Eva E, Saemann, Marcus, Novotny, Veronica, Bohmig, Georg, Csonga, Robert, Baumruker, Thomas, Zlabinger, Gerhard J

“…The transcription factor nuclear factor of activated T-cells (NF-AT) plays an essential role in the activation of many early immune response genes. A dynamic…”
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Suppression of primary T-cell responses and induction of alloantigen-specific hyporesponsiveness in vitro by the janus kinase inhibitor tyrphostin AG490 by SÄEMANN, Marcus D, BÖHMIG, Georg A, ÖSTERREICHER, Christoph H, STAFFLER, Günther, DIAKOS, Christos, KRIEGER, Peter-Michael, HÖRL, Walter H, STOCKINGER, Hannes, ZLABINGER, Gerhard J

“…Tyrphostin AG490 has recently been shown to block interleukin (IL)-2 receptor gamma-chain-associated Janus kinase 3. Here, we analyzed the effect of AG490 on…”
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Investigations into the Interactions between DNA and Conformationally Constrained Pyridylamineplatinum(II) Analogues of AMD473 by Munk, Vivienne P, Diakos, Connie I, Ellis, Leanne T, Fenton, Ronald R, Messerle, Barbara A, Hambley, Trevor W

“…The syntheses of [PtCl2(amp)] (amp = 2-pyridylmethylamine) and enantiomerically pure [PtCl2(R-pea)] and [PtCl2(S-pea)] (pea = 1-(2-pyridyl)ethylamine) and the…”
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Stereospecificity and Enantioselectivity in the Binding of the Platinum(II) Complex [PtCl2(tmdz)] (tmdz=5,5,7-Trimethyl-1,4-diazacycloheptane) to Dinucleotides and Oligonucleotides by Munk, Vivienne P., Diakos, Connie I., Messerle, Barbara A., Fenton, Ronald R., Hambley, Trevor W.

“…The two stereoisomers formed on reaction of each of the enantiomers of [PtCl2(tmdz)] with d(GpG) have been identified by using one‐ and two‐dimensional 1H NMR…”
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