Search Results - "Diabetologia"

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    Global trends in diabetes complications: a review of current evidence by Harding, Jessica L., Pavkov, Meda E., Magliano, Dianna J., Shaw, Jonathan E., Gregg, Edward W.

    Published in Diabetologia (2019)
    “…In recent decades, large increases in diabetes prevalence have been demonstrated in virtually all regions of the world. The increase in the number of people…”
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    Sex differences in metabolic regulation and diabetes susceptibility by Tramunt, Blandine, Smati, Sarra, Grandgeorge, Naia, Lenfant, Françoise, Arnal, Jean-François, Montagner, Alexandra, Gourdy, Pierre

    Published in Diabetologia (01-03-2020)
    “…Gender and biological sex impact the pathogenesis of numerous diseases, including metabolic disorders such as diabetes. In most parts of the world, diabetes is…”
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    The mechanisms of action of metformin by Rena, Graham, Hardie, D. Grahame, Pearson, Ewan R.

    Published in Diabetologia (01-09-2017)
    “…Metformin is a widely-used drug that results in clear benefits in relation to glucose metabolism and diabetes-related complications. The mechanisms underlying…”
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    Gestational diabetes and the risk of cardiovascular disease in women: a systematic review and meta-analysis by Kramer, Caroline K., Campbell, Sara, Retnakaran, Ravi

    Published in Diabetologia (01-06-2019)
    “…Aims/hypothesis Women who develop gestational diabetes mellitus (GDM) have an elevated lifetime risk of type 2 diabetes mellitus. Recently, a series of studies…”
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    SGLT2 inhibitors and mechanisms of cardiovascular benefit: a state-of-the-art review by Verma, Subodh, McMurray, John J. V.

    Published in Diabetologia (01-10-2018)
    “…Sodium–glucose cotransporter (SGLT)2 inhibitors have been demonstrated to reduce cardiovascular events, particularly heart failure, in cardiovascular outcome…”
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    Metformin: historical overview by Bailey, Clifford J.

    Published in Diabetologia (01-09-2017)
    “…Metformin (dimethylbiguanide) has become the preferred first-line oral blood glucose-lowering agent to manage type 2 diabetes. Its history is linked to Galega…”
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    Diabetic cardiomyopathy: a hyperglycaemia- and insulin-resistance-induced heart disease by Jia, Guanghong, Whaley-Connell, Adam, Sowers, James R.

    Published in Diabetologia (01-01-2018)
    “…Diabetic cardiomyopathy is characterised in its early stages by diastolic relaxation abnormalities and later by clinical heart failure in the absence of…”
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    Neurodegeneration in diabetic retinopathy: does it really matter? by Simó, Rafael, Stitt, Alan W., Gardner, Thomas W.

    Published in Diabetologia (01-09-2018)
    “…The concept of diabetic retinopathy as a microvascular disease has evolved, in that it is now considered a more complex diabetic complication in which…”
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    Canagliflozin reduces inflammation and fibrosis biomarkers: a potential mechanism of action for beneficial effects of SGLT2 inhibitors in diabetic kidney disease by Heerspink, Hiddo J. L., Perco, Paul, Mulder, Skander, Leierer, Johannes, Hansen, Michael K., Heinzel, Andreas, Mayer, Gert

    Published in Diabetologia (01-07-2019)
    “…Aims/hypothesis The sodium–glucose cotransporter 2 (SGLT2) inhibitor canagliflozin slows progression of kidney function decline in type 2 diabetes. The aim of…”
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    New insights into the mechanisms of diabetic complications: role of lipids and lipid metabolism by Eid, Stephanie, Sas, Kelli M., Abcouwer, Steven F., Feldman, Eva L., Gardner, Thomas W., Pennathur, Subramaniam, Fort, Patrice E.

    Published in Diabetologia (01-09-2019)
    “…Diabetes adversely affects multiple organs, including the kidney, eye and nerve, leading to diabetic kidney disease, diabetic retinopathy and diabetic…”
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    Hypoxia and hypoxia-inducible factors in diabetes and its complications by Catrina, Sergiu-Bogdan, Zheng, Xiaowei

    Published in Diabetologia (01-04-2021)
    “…Hypoxia-inducible factors (HIFs) are the key regulators of oxygen homeostasis in response to hypoxia. In diabetes, multiple tissues are hypoxic but adaptive…”
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    Sex differences in type 2 diabetes by Kautzky-Willer, Alexandra, Leutner, Michael, Harreiter, Jürgen

    Published in Diabetologia (01-06-2023)
    “…The prevalence of type 2 diabetes mellitus is increasing in both sexes, but men are usually diagnosed at a younger age and lower body fat mass than women…”
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