Search Results - "Diabetes (New York, N.Y.)"

Short-Chain Fatty Acids Protect Against High-Fat Diet-Induced Obesity via a PPAR?-Dependent Switch From Lipogenesis to Fat Oxidation by den Besten, Gijs, Bleeker, Aycha, Gerding, Albert, Eunen, Karen van, Havinga, Rick, van Dijk, Theo H, Oosterveer, Maaike H, Jonker, Johan W, Groen, Albert K, Reijngoud, Dirk-Jan, Bakker, Barbara M

“…Short-chain fatty acids (SCFAs) are the main products of dietary fiber fermentation and are believed to drive the fiber-related prevention of the metabolic…”
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Aging, Male Sex, Obesity, and Metabolic Inflammation Create the Perfect Storm for COVID-19 by Mauvais-Jarvis, Franck

“…Coronavirus disease 2019 (COVID-19) is a novel threat that seems to result from the collusion between a new pandemic of severe acute respiratory syndrome…”
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circRNA_010383 Acts as a Sponge for miR-135a, and Its Downregulated Expression Contributes to Renal Fibrosis in Diabetic Nephropathy by Peng, Fenfen, Gong, Wangqiu, Li, Shuting, Yin, Bohui, Zhao, Chen, Liu, Wenting, Chen, Xiaowen, Luo, Congwei, Huang, Qianying, Chen, Ting, Sun, Lingzhi, Fang, Shun, Zhou, Weidong, Li, Zhijian, Long, Haibo

“…Diabetic nephropathy (DN), a vascular complication of diabetes, is the leading cause of death in patients with diabetes. The contribution of aberrantly…”
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Screening for Type 1 Diabetes in the General Population: A Status Report and Perspective by Sims, Emily K, Besser, Rachel E J, Dayan, Colin, Geno Rasmussen, Cristy, Greenbaum, Carla, Griffin, Kurt J, Hagopian, William, Knip, Mikael, Long, Anna E, Martin, Frank, Mathieu, Chantal, Rewers, Marian, Steck, Andrea K, Wentworth, John M, Rich, Stephen S, Kordonouri, Olga, Ziegler, Anette-Gabriele, Herold, Kevan C

“…Most screening programs to identify individuals at risk for type 1 diabetes have targeted relatives of people living with the disease to improve yield and…”
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Specific NLRP3 Inhibition Protects Against Diabetes-Associated Atherosclerosis by Sharma, Arpeeta, Choi, Judy S Y, Stefanovic, Nada, Al-Sharea, Annas, Simpson, Daniel S, Mukhamedova, Nigora, Jandeleit-Dahm, Karin, Murphy, Andrew J, Sviridov, Dmitri, Vince, James E, Ritchie, Rebecca H, de Haan, Judy B

“…Low-grade persistent inflammation is a feature of diabetes-driven vascular complications, in particular activation of the Nod-like receptor family pyrin domain…”
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Insulitis and [Beta]-Cell Mass in the Natural History of Type 1 Diabetes by Campbell-Thompson, Martha, Fu, Ann, Kaddis, John S, Wasserfall, Clive, Schatz, Desmond A, Pugliese, Alberto, Atkinson, Mark A

“…Descriptions of insulitis in human islets throughout the natural history of type 1 diabetes are limited. We determined insulitis frequency (the percent of…”
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Is Type 2 Diabetes Causally Associated With Cancer Risk? Evidence From a Two-Sample Mendelian Randomization Study by Yuan, Shuai, Kar, Siddhartha, Carter, Paul, Vithayathil, Mathew, Mason, Amy M, Burgess, Stephen, Larsson, Susanna C

“…We conducted a two-sample Mendelian randomization study to investigate the causal associations of type 2 diabetes mellitus (T2DM) with risk of overall cancer…”
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Circulating MicroRNA-122 Is Associated With the Risk of New-Onset Metabolic Syndrome and Type 2 Diabetes by Willeit, Peter, Skroblin, Philipp, Moschen, Alexander R, Yin, Xiaoke, Kaudewitz, Dorothee, Zampetaki, Anna, Barwari, Temo, Whitehead, Meredith, Ramírez, Cristina M, Goedeke, Leigh, Rotllan, Noemi, Bonora, Enzo, Hughes, Alun D, Santer, Peter, Fernández-Hernando, Carlos, Tilg, Herbert, Willeit, Johann, Kiechl, Stefan, Mayr, Manuel

“…MicroRNA-122 (miR-122) is abundant in the liver and involved in lipid homeostasis, but its relevance to the long-term risk of developing metabolic disorders is…”
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Differential Insulitic Profiles Determine the Extent of β-Cell Destruction and the Age at Onset of Type 1 Diabetes by Leete, Pia, Willcox, Abby, Krogvold, Lars, Dahl-Jørgensen, Knut, Foulis, Alan K, Richardson, Sarah J, Morgan, Noel G

“…Type 1 diabetes (T1D) results from a T cell-mediated destruction of pancreatic β-cells following the infiltration of leukocytes (including CD8(+), CD4(+), and…”
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A Genome-Wide Association Study of Diabetic Kidney Disease in Subjects With Type 2 Diabetes by van Zuydam, Natalie R, Ahlqvist, Emma, Sandholm, Niina, Deshmukh, Harshal, Rayner, N William, Abdalla, Moustafa, Ladenvall, Claes, Ziemek, Daniel, Fauman, Eric, Robertson, Neil R, McKeigue, Paul M, Valo, Erkka, Forsblom, Carol, Harjutsalo, Valma, Perna, Annalisa, Rurali, Erica, Marcovecchio, M Loredana, Igo, Jr, Robert P, Salem, Rany M, Perico, Norberto, Lajer, Maria, Käräjämäki, Annemari, Imamura, Minako, Kubo, Michiaki, Takahashi, Atsushi, Sim, Xueling, Liu, Jianjun, van Dam, Rob M, Jiang, Guozhi, Tam, Claudia H T, Luk, Andrea O Y, Lee, Heung Man, Lim, Cadmon K P, Szeto, Cheuk Chun, So, Wing Yee, Chan, Juliana C N, Ang, Su Fen, Dorajoo, Rajkumar, Wang, Ling, Clara, Tan Si Hua, McKnight, Amy-Jayne, Duffy, Seamus, Pezzolesi, Marcus G, Marre, Michel, Gyorgy, Beata, Hadjadj, Samy, Hiraki, Linda T, Ahluwalia, Tarunveer S, Almgren, Peter, Schulz, Christina-Alexandra, Orho-Melander, Marju, Linneberg, Allan, Christensen, Cramer, Witte, Daniel R, Grarup, Niels, Brandslund, Ivan, Melander, Olle, Paterson, Andrew D, Tregouet, David, Maxwell, Alexander P, Lim, Su Chi, Ma, Ronald C W, Tai, E Shyong, Maeda, Shiro, Lyssenko, Valeriya, Tuomi, Tiinamaija, Krolewski, Andrzej S, Rich, Stephen S, Hirschhorn, Joel N, Florez, Jose C, Dunger, David, Pedersen, Oluf, Hansen, Torben, Rossing, Peter, Remuzzi, Giuseppe, Brosnan, Mary Julia, Palmer, Colin N A, Groop, Per-Henrik, Colhoun, Helen M, Groop, Leif C, McCarthy, Mark I

“…Identification of sequence variants robustly associated with predisposition to diabetic kidney disease (DKD) has the potential to provide insights into the…”
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Differential Insulitic Profiles Determine the Extent of [Beta]-Cell Destruction and the Age at Onset of Type 1 Diabetes by Leete, Pia, Willcox, Abby, Krogvold, Lars, Dahl-Jørgensen, Knut, Foulis, Alan K, Richardson, Sarah J, Morgan, Noel G

“…Type 1 diabetes (T1D) results from a T cell-mediated destruction of pancreatic ...-cells following the infiltration of leukocytes (including CD8+, CD4+, and…”
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Collateral Damage: Insulin-Dependent Diabetes Induced With Checkpoint Inhibitors by Stamatouli, Angeliki M, Quandt, Zoe, Perdigoto, Ana Luisa, Clark, Pamela L, Kluger, Harriet, Weiss, Sarah A, Gettinger, Scott, Sznol, Mario, Young, Arabella, Rushakoff, Robert, Lee, James, Bluestone, Jeffrey A, Anderson, Mark, Herold, Kevan C

“…Insulin-dependent diabetes may occur in patients with cancers who are treated with checkpoint inhibitors (CPIs). We reviewed cases occurring over a 6-year…”
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An Expanded Genome-Wide Association Study of Type 2 Diabetes in Europeans by Scott, Robert A, Scott, Laura J, Mägi, Reedik, Marullo, Letizia, Gaulton, Kyle J, Kaakinen, Marika, Pervjakova, Natalia, Pers, Tune H, Johnson, Andrew D, Eicher, John D, Jackson, Anne U, Ferreira, Teresa, Lee, Yeji, Ma, Clement, Steinthorsdottir, Valgerdur, Thorleifsson, Gudmar, Qi, Lu, Van Zuydam, Natalie R, Mahajan, Anubha, Chen, Han, Almgren, Peter, Voight, Ben F, Grallert, Harald, Müller-Nurasyid, Martina, Ried, Janina S, Rayner, Nigel W, Robertson, Neil, Karssen, Lennart C, van Leeuwen, Elisabeth M, Willems, Sara M, Fuchsberger, Christian, Kwan, Phoenix, Teslovich, Tanya M, Chanda, Pritam, Li, Man, Lu, Yingchang, Dina, Christian, Thuillier, Dorothee, Yengo, Loic, Jiang, Longda, Sparso, Thomas, Kestler, Hans A, Chheda, Himanshu, Eisele, Lewin, Gustafsson, Stefan, Frånberg, Mattias, Strawbridge, Rona J, Benediktsson, Rafn, Hreidarsson, Astradur B, Kong, Augustine, Sigurðsson, Gunnar, Kerrison, Nicola D, Luan, Jian'an, Liang, Liming, Meitinger, Thomas, Roden, Michael, Thorand, Barbara, Esko, Tõnu, Mihailov, Evelin, Fox, Caroline, Liu, Ching-Ti, Rybin, Denis, Isomaa, Bo, Lyssenko, Valeriya, Tuomi, Tiinamaija, Couper, David J, Pankow, James S, Grarup, Niels, Have, Christian T, Jørgensen, Marit E, Jørgensen, Torben, Linneberg, Allan, Cornelis, Marilyn C, van Dam, Rob M, Hunter, David J, Kraft, Peter, Sun, Qi, Edkins, Sarah, Owen, Katharine R, Perry, John R B, Wood, Andrew R, Zeggini, Eleftheria, Tajes-Fernandes, Juan, Abecasis, Goncalo R, Bonnycastle, Lori L, Chines, Peter S, Stringham, Heather M, Koistinen, Heikki A, Kinnunen, Leena, Sennblad, Bengt, Mühleisen, Thomas W, Nöthen, Markus M, Pechlivanis, Sonali, Baldassarre, Damiano, Gertow, Karl, Humphries, Steve E, Tremoli, Elena, Klopp, Norman, Meyer, Julia, Steinbach, Gerald

“…To characterize type 2 diabetes (T2D)-associated variation across the allele frequency spectrum, we conducted a meta-analysis of genome-wide association data…”
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Exosomes From Adipose-Derived Stem Cells Attenuate Adipose Inflammation and Obesity Through Polarizing M2 Macrophages and Beiging in White Adipose Tissue by Zhao, Hui, Shang, Qianwen, Pan, Zhenzhen, Bai, Yang, Li, Zequn, Zhang, Huiying, Zhang, Qiu, Guo, Chun, Zhang, Lining, Wang, Qun

“…Adipose-derived stem cells (ADSCs) play critical roles in controlling obesity-associated inflammation and metabolic disorders. Exosomes from ADSCs exert…”
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Acylcarnitines: reflecting or inflicting insulin resistance? by Schooneman, Marieke G, Vaz, Frédéric M, Houten, Sander M, Soeters, Maarten R

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High-Dose Resveratrol Supplementation in Obese Men: An Investigator-Initiated, Randomized, Placebo-Controlled Clinical Trial of Substrate Metabolism, Insulin Sensitivity, and Body Composition by POULSEN, Morten M, VESTERGAARD, Poul F, CLASEN, Berthil F, RADKO, Yulia, CHRISTENSEN, Lars P, STØDKILDE-JØRGENSEN, Hans, MØLLER, Niels, JESSEN, Niels, PEDERSEN, Steen B, JØRGENSEN, Jens Otto L

“…Obesity, diabetes, hypertension, and hyperlipidemia constitute risk factors for morbidity and premature mortality. Based on animal and in vitro studies,…”
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Differential Adaptation of Human Gut Microbiota to Bariatric Surgery-Induced Weight Loss: Links With Metabolic and Low-Grade Inflammation Markers by FURET, Jean-Pierre, KONG, Ling-Chun, RIZKALLA, Salwa, CLEMENT, Karine, TAP, Julien, POITOU, Christine, BASDEVANT, Arnaud, BOUILLOT, Jean-Luc, MARIAT, Denis, CORTHIER, Gérard, DORE, Joël, HENEGAR, Corneliu

“…Obesity alters gut microbiota ecology and associates with low-grade inflammation in humans. Roux-en-Y gastric bypass (RYGB) surgery is one of the most…”
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Primary Human and Rat β-Cells Release the Intracellular Autoantigens GAD65, IA-2, and Proinsulin in Exosomes Together With Cytokine-Induced Enhancers of Immunity by Cianciaruso, Chiara, Phelps, Edward A, Pasquier, Miriella, Hamelin, Romain, Demurtas, Davide, Alibashe Ahmed, Mohamed, Piemonti, Lorenzo, Hirosue, Sachiko, Swartz, Melody A, De Palma, Michele, Hubbell, Jeffrey A, Baekkeskov, Steinunn

“…The target autoantigens in several organ-specific autoimmune diseases, including type 1 diabetes (T1D), are intracellular membrane proteins, whose initial…”
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Marked Expansion of Exocrine and Endocrine Pancreas With Incretin Therapy in Humans With Increased Exocrine Pancreas Dysplasia and the Potential for Glucagon-Producing Neuroendocrine Tumors by BUTLER, Alexandra E, CAMPBELL-THOMPSON, Martha, GURLO, Tatyana, DAWSON, David W, ATKINSON, Mark, BUTLER, Peter C

“…Controversy exists regarding the potential regenerative influences of incretin therapy on pancreatic β-cells versus possible adverse pancreatic proliferative…”
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New Understanding of β-Cell Heterogeneity and In Situ Islet Function by Benninger, Richard K P, Hodson, David J

“…Insulin-secreting β-cells are heterogeneous in their regulation of hormone release. While long known, recent technological advances and new markers have…”
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