Search Results - "DiScipio, Richard G."

The chemokine CCL18 causes maturation of cultured monocytes to macrophages in the M2 spectrum by Schraufstatter, Ingrid U., Zhao, Ming, Khaldoyanidi, Sophia K., DiScipio, Richard G.

“…Summary The observation that human monocytes cultured in the presence of the chemokine CCL18 showed increased survival, led us to profile cytokine expression…”
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C3a and C5a Are Chemotactic Factors for Human Mesenchymal Stem Cells, Which Cause Prolonged ERK1/2 Phosphorylation by Schraufstatter, Ingrid U, DiScipio, Richard G, Zhao, Ming, Khaldoyanidi, Sophia K

“…Mesenchymal stem cells (MSCs) have a great potential for tissue repair, especially if they can be delivered efficiently to sites of tissue injury. Since…”
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Structure of Complement C6 Suggests a Mechanism for Initiation and Unidirectional, Sequential Assembly of Membrane Attack Complex (MAC) by Aleshin, Alexander E., Schraufstatter, Ingrid U., Stec, Boguslaw, Bankston, Laurie A., Liddington, Robert C., DiScipio, Richard G.

“…The complement membrane attack complex (MAC) is formed by the sequential assembly of C5b with four homologous proteins as follows: one copy each of C6, C7, and…”
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Crystal Structure of C5b-6 Suggests Structural Basis for Priming Assembly of the Membrane Attack Complex by Aleshin, Alexander E., DiScipio, Richard G., Stec, Boguslaw, Liddington, Robert C.

“…The complement membrane attack complex (MAC) forms transmembrane pores in pathogen membranes. The first step in MAC assembly is cleavage of C5 to generate…”
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The role of the complement anaphylatoxins in the recruitment of eosinophils by DiScipio, Richard G., Schraufstatter, Ingrid U.

“…Eosinophils are blood and tissue immune cells that participate in a diverse range of activities normally beneficial for the host defense, but in circumstances…”
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Arrestin Regulates MAPK Activation and Prevents NADPH Oxidase-dependent Death of Cells Expressing CXCR2 by Zhao, Ming, Wimmer, Antonia, Trieu, Khanh, Discipio, Richard G, Schraufstatter, Ingrid U

“…Activation of CXCR2 IL-8 receptor leads to activation of extracellular signal-regulated kinases 1 and 2 (ERK1/2) and rapid receptor endocytosis…”
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Regulation of CXCR4-mediated nuclear translocation of extracellular signal-related kinases 1 and 2 by Zhao, Ming, Discipio, Richard G, Wimmer, Antonia G, Schraufstatter, Ingrid U

“…Activation of the chemokine receptor CXCR4 by its agonist stromal cell-derived factor 1 (SDF-1) has been associated with cell migration and proliferation in…”
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Eosinophils and monocytes produce pulmonary and activation-regulated chemokine, which activates cultured monocytes/macrophages by Schraufstatter, Ingrid, Takamori, Hiroshi, Sikora, Lyudmila, Sriramarao, P, DiScipio, Richard G

“…Pulmonary and activation-regulated chemokine (PARC/CCL18) belongs to the family of CC chemokines and shares 61% sequence identity with monocyte inflammatory…”
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A Comparison of C3a and C5a-Mediated Stable Adhesion of Rolling Eosinophils in Postcapillary Venules and Transendothelial Migration In Vitro and In Vivo by DiScipio, Richard G, Daffern, Pamela J, Jagels, Mark A, Broide, David H, Sriramarao, P

“…The comparative ability of the complement anaphylatoxins C3a and C5a to mediate leukocyte adhesion and transendothelial migration in vivo and in vitro was…”
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Magnetic bead based assays for complement component C5 by DiScipio, Richard G., Schraufstatter, Ingrid U.

“…Two novel magnetic agarose bead based assays have been developed to measure complement component C5 interaction with C3b and the Factor I Modules (FIMs) of C7…”
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Mesenchymal stem cells and their microenvironment by Schraufstatter, Ingrid U, Discipio, Richard G, Khaldoyanidi, Sophia

“…Mesenchymal stem cells (MSC) are multipotent stem cells that hold promise for an expanding list of therapeutic uses, not only due to their ability to…”
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Complement activation in the context of stem cells and tissue repair by Schraufstatter, Ingrid U, Khaldoyanidi, Sophia K, DiScipio, Richard G

“…The complement pathway is best known for its role in immune surveillance and inflammation. However,its ability of opsonizing and removing not only…”
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Fibulin-1 purification from human plasma using affinity chromatography on Factor H-Sepharose by DiScipio, Richard G., Liddington, Robert C., Schraufstatter, Ingrid U.

“…A method is reported to purify Fibulin-1 from human plasma resulting in a 36% recovery. The steps involve removal of the cryoglobulin and the vitamin K…”
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Akt plays an important role in breast cancer cell chemotaxis to CXCL12 by Zhao, Ming, Mueller, Barbara M., DiScipio, Richard G., Schraufstatter, Ingrid U.

“…The chemokine receptor CXCR4 is functionally expressed on the cell surface of various cancer cells, and plays a role in cell proliferation and migration of…”
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Expression of soluble proteins in Escherichia coli by linkage with the acidic propiece of eosinophil major basic protein by DiScipio, Richard G., Khaldoyanidi, Sophia K., Schraufstatter, Ingrid U.

“…An expression method has been developed to produce soluble cationic polypeptides in Escherichia coli while avoiding inclusion body deposition. For this…”
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CCL18/PARC stimulates hematopoiesis in long-term bone marrow cultures indirectly through its effect on monocytes by Wimmer, Antonia, Khaldoyanidi, Sophia K., Judex, Martin, Serobyan, Naira, DiScipio, Richard G., Schraufstatter, Ingrid U.

“…Chemokines play a role in regulating hematopoietic stem cell function, including migration, proliferation, and retention. We investigated the involvement of…”
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Alpha 7 subunit of nAChR regulates migration of human mesenchymal stem cells by Schraufstatter, Ingrid U, DiScipio, Richard G, Khaldoyanidi, Sophia K

“…The efficient migration of mesenchymal stem cells (MSCs) to diseased tissues is required for the fulfillment of their regenerative potential. Recruitment of…”
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C5a mediates secretion and activation of matrix metalloproteinase 9 from human eosinophils and neutrophils by DiScipio, Richard G., Schraufstatter, Ingrid U., Sikora, Lyudmila, Zuraw, Bruce L., Sriramarao, P.

“…Matrix metalloproteinase 9 (MMP-9) is a crucial proteinase, utilized by both eosinophils and neutrophils, that mediates transmigration through extracellular…”
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VCAM-1 is more effective than MAdCAM-1 in supporting eosinophil rolling under conditions of shear flow by SRIRAMARAO, P, DISCIPIO, R. G, COBB, R. R, CYBULSKY, M, STACHNICK, G, CASTANEDA, D, ELICES, M, BROIDE, D. H

“…The ability of the alpha4 integrin counterligands vascular cell adhesion molecule (VCAM)-1 or mucosal addressin (MAd)CAM-1 to support eosinophil rolling or…”
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Function of the Factor I Modules (FIMS) of Human Complement Component C6 by DiScipio, Richard G., Linton, Stuart M., Rushmere, Neil K.

“…In order to elucidate the function of complement component C6, truncated C6 molecules were expressed recombinantly. These were either deleted of the factor I…”
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