Search Results - "DiSanto, Michael E"
-
1
Glutathione Peroxidase 3 induced mitochondria-mediated apoptosis via AMPK /ERK1/2 pathway and resisted autophagy-related ferroptosis via AMPK/mTOR pathway in hyperplastic prostate
Published in Journal of translational medicine (26-08-2023)“…Abstract Background Benign prostatic hyperplasia (BPH) is a common disease in elderly men, mainly resulted from an imbalance between cell proliferation and…”
Get full text
Journal Article -
2
Simvastatin Improves Benign Prostatic Hyperplasia: Role of Peroxisome-Proliferator-Activated Receptor-γ and Classic WNT/β-Catenin Pathway
Published in International journal of molecular sciences (01-03-2023)“…Benign prostatic hyperplasia (BPH) is a common disease in elderly men with an uncertain etiology and mechanistic basis. Metabolic syndrome (MetS) is also a…”
Get full text
Journal Article -
3
The Emerging Role of Cell Adhesion Molecules on Benign Prostatic Hyperplasia
Published in International journal of molecular sciences (02-02-2023)“…Benign prostatic hyperplasia (BPH) is a common disease in elderly men. It is characterized by prostatic enlargement and urethral compression and often causes…”
Get full text
Journal Article -
4
Mechanism of RhoA regulating benign prostatic hyperplasia: RhoA-ROCK-β-catenin signaling axis and static & dynamic dual roles
Published in Molecular medicine (Cambridge, Mass.) (20-10-2023)“…Abstract Background The pathogenesis of benign prostatic hyperplasia (BPH) has not been fully elucidated. Ras homology family member A (RhoA) plays an…”
Get full text
Journal Article -
5
M2a macrophage can rescue proliferation and gene expression of benign prostate hyperplasia epithelial and stroma cells from insulin‐like growth factor 1 knockdown
Published in The Prostate (01-06-2021)“…Background Benign prostatic hyperplasia (BPH) is a common disease in elderly men and is often accompanied by chronic inflammation. Macrophages (several…”
Get full text
Journal Article -
6
Heat Shock Protein 70 and 90 Family in Prostate Cancer
Published in Life (Basel, Switzerland) (26-09-2022)“…Prostate cancer (PCa) is the second most frequent cancer that affects aging men worldwide. However, its exact pathogenesis has not been fully elucidated. The…”
Get full text
Journal Article -
7
Changes in the Expression and Functional Activities of C-X-C Motif Chemokine Ligand 13 ( CXCL13 ) in Hyperplastic Prostate
Published in International journal of molecular sciences (21-12-2022)“…C-X-C motif chemokine ligand 13 ( ), a member of the CXC subtype in chemokine superfamily, affects numerous biological processes of various types of cells and…”
Get full text
Journal Article -
8
Glucose-regulated protein 78 modulates cell growth, epithelial–mesenchymal transition, and oxidative stress in the hyperplastic prostate
Published in Cell death & disease (24-01-2022)“…Benign prostatic hyperplasia (BPH) is a chronic condition which mainly affects elderly males. Existing scientific evidences have not completely revealed the…”
Get full text
Journal Article -
9
The Role of Heat Shock Protein 70 Subfamily in the Hyperplastic Prostate: From Molecular Mechanisms to Therapeutic Opportunities
Published in Cells (Basel, Switzerland) (28-06-2022)“…Benign prostatic hyperplasia (BPH) is one of the most common causes of lower urinary tract symptoms (LUTS) in men, which is characterized by a noncancerous…”
Get full text
Journal Article -
10
Blebbistatin modulates prostatic cell growth and contrapctility through myosin II signaling
Published in Clinical science (1979) (31-10-2018)“…To investigate the effect of blebbistatin (BLEB, a selective myosin inhibitor) on regulating contractility and growth of prostate cells and to provide insight…”
Get more information
Journal Article -
11
Upregulated Interleukin 21 Receptor Enhances Proliferation and Epithelial-Mesenchymal Transition Process in Benign Prostatic Hyperplasia
Published in Frontiers in endocrinology (Lausanne) (2019)“…Interleukins (ILs) and related chronic inflammation have been found to contribute to the development of benign prostatic hyperplasia (BPH) in recent decades…”
Get full text
Journal Article -
12
The Immune-Related Gene HCST as a Novel Biomarker for the Diagnosis and Prognosis of Clear Cell Renal Cell Carcinoma
Published in Frontiers in oncology (23-04-2021)“…Clear cell renal cell carcinoma (ccRCC) is the most common type of kidney tumor worldwide. Analysis of The Cancer Genome Atlas (TCGA) and Gene Expression…”
Get full text
Journal Article -
13
Upregulation of Oxytocin Receptor in the Hyperplastic Prostate
Published in Frontiers in endocrinology (Lausanne) (03-08-2018)“…The etiology of benign prostatic hyperplasia (BPH) is complex, both age and androgen are thought to be important. However, the failure of androgen blockade…”
Get full text
Journal Article -
14
Blebbistain, a myosin II inhibitor, as a novel strategy to regulate detrusor contractility in a rat model of partial bladder outlet obstruction
Published in PloS one (07-10-2011)“…Partial bladder outlet obstruction (PBOO), a common urologic pathology mostly caused by benign prostatic hyperplasia, can coexist in 40-45% of patients with…”
Get full text
Journal Article -
15
Smoothened inhibition leads to decreased cell proliferation and suppressed tissue fibrosis in the development of benign prostatic hyperplasia
Published in Cell death discovery (18-05-2021)“…Benign prostatic hyperplasia (BPH) is a common disease in aging males. It has been proven that the Hedgehog (HH) is implied as an effective and fundamental…”
Get full text
Journal Article -
16
Identification of Seven Aberrantly Methylated and Expressed Genes in Adrenocortical Carcinoma
Published in Frontiers in endocrinology (Lausanne) (12-07-2019)“…Adrenocortical carcinoma (ACC) is a rare endocrine malignancy with an unfavorable prognosis and limited treatment options. Nevertheless, no clinically…”
Get full text
Journal Article -
17
Obstruction-induced changes in urinary bladder smooth muscle contractility: a role for Rho kinase
Published in American journal of physiology. Renal physiology (01-11-2003)“…Detrusor smooth muscle (DSM) undergoes hypertrophy after partial bladder outlet obstruction (PBOO) in male rabbits, as it does in men with PBOO induced by…”
Get more information
Journal Article -
18
S100A4 modulates cell proliferation, apoptosis and fibrosis in the hyperplastic prostate
Published in The international journal of biochemistry & cell biology (01-04-2024)“…Benign prostatic hyperplasia (BPH) is one of the most common diseases in elderly men worldwide that may result in lower urinary tract symptoms (LUTS). At…”
Get full text
Journal Article -
19
Expression and functional activity of myosin II in hyperplastic prostates of varying volumes
Published in Cellular signalling (01-06-2023)“…Prostate volume (PV) differs dramatically among benign prostatic hyperplasia (BPH) patients. Estimation of PV is important to guide the most appropriate…”
Get full text
Journal Article -
20
DHCR7 promotes tumorigenesis via activating PI3K/AKT/mTOR signalling pathway in bladder cancer
Published in Cellular signalling (01-02-2023)“…Bladder cancer (BCa) is a common malignancy with uncertain molecular mechanism. 7-dehydrocholesterol reductase (DHCR7), the enzyme of mammalian sterol…”
Get full text
Journal Article