Search Results - "DiPolo, Reinaldo"

Sodium/Calcium Exchanger: Influence of Metabolic Regulation on Ion Carrier Interactions by Dipolo, Reinaldo, Beauge, Luis

“…Laboratorio de Permebilidad Ionica, Centro de Biofísica y Bioquímica, Instituío Venezolano de Investigaciones Científicas, Caracas, Venezuela; and Laboratorio…”
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The marine sponge toxin agelasine B increases the intracellular Ca2+ concentration and induces apoptosis in human breast cancer cells (MCF-7) by Pimentel, Adriana A., Felibertt, Pimali, Sojo, Felipe, Colman, Laura, Mayora, Adriana, Silva, May Li, Rojas, Hector, Dipolo, Reinaldo, Suarez, Alírica I., Compagnone, Reinaldo S., Arvelo, Francisco, Galindo-Castro, Ivan, De Sanctis, Juan B., Chirino, Perla, Benaim, Gustavo

“…Purpose In search for new drugs derived from natural products for the possible treatment of cancer, we studied the action of agelasine B, a compound purified…”
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Intracellular calcium clearance in Purkinje cell somata from rat cerebellar slices by Fierro, Leonardo, DiPolo, Reinaldo, Llano, Isabel

“…The mechanisms governing the return of intracellular calcium to baseline levels following depolarization-evoked [Ca 2+ ] i rises were investigated in Purkinje…”
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Factors affecting SOCE activation in mammalian skeletal muscle fibers by Bolaños, Pura, Guillén, Alis, DiPolo, Reinaldo, Caputo, Carlo

“…Enzymatically dissociated mouse FDB muscle fibers, loaded with Fura-2 AM, were used to study the effect of mitochondrial uncoupling on the capacitative Ca(2+)…”
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SEA-0400, a potent inhibitor of the Na+/Ca2+ exchanger, as a tool to study exchanger ionic and metabolic regulation by Beaugé, Luis, DiPolo, Reinaldo

“…The effects of a new, potent, and selective inhibitor of the Na(+)/Ca(2+) exchange, SEA-0400 (SEA), on steady-state outward (forward exchange), inward (reverse…”
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The Activity of the Na+/Ca2+ Exchanger Largely Modulates the Ca2+i Signal Induced by Hypo-Osmotic Stress in Rat Cerebellar Astrocytes. The Effect of Osmolarity on Exchange Activity by Rojas, Héctor, Ramos, Magaly, Benaim, Gustavo, Caputo, Carlo, DiPolo, Reinaldo

“…We recently demonstrated that rat cerebellar Type-1 astrocytes express a very active Na+/Ca2+ exchanger highly colocalized with ryanodine receptors (RyRs),…”
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MgATP counteracts intracellular proton inhibition of the sodium-calcium exchanger in dialysed squid axons by DiPolo, Reinaldo, Beaugé, Luis

“…Intracellular Na + and H + inhibit Na + -Ca 2+ exchange. ATP regulates exchange activity by altering kinetic parameters for , and . The role of the regulatory…”
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Na+ entry via glutamate transporter activates the reverse Na+/Ca2+ exchange and triggers ‐induced Ca2+ release in rat cerebellar Type‐1 astrocytes by Rojas, Héctor, Colina, Claudia, Ramos, Magaly, Benaim, Gustavo, Jaffe, Erica H., Caputo, Carlo, DiPolo, Reinaldo

“…We have previously demonstrated that rat cerebellar Type‐1 astrocytes express a very active genistein sensitive Na+/Ca2+ exchanger, which accounts for most of…”
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Metabolic pathways in the regulation of invertebrate and vertebrate Na+/Ca2+ exchange by DiPolo, R, Beaugé, L

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Differential up-regulation of Na+-Ca2+ exchange by phosphoarginine and ATP in dialysed squid axons by DiPolo, Reinaldo, Beaugé, Luis

“…The aim of this study was to characterize further the two main metabolic pathways of regulation of the Na + -Ca 2+ exchanger in squid axons induced by its two…”
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In dialyzed squid axons oxidative stress inhibits the Na+/Ca2+ exchanger by impairing the Cai2+-regulatory site by DiPolo, Reinaldo, Beaugé, Luis

“…The Na(+)/Ca(2+) exchanger, a major mechanism by which cells extrude calcium, is involved in several physiological and physiopathological interactions. In this…”
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In the squid axon Na+/Ca2+ exchanger the state of the Ca i-regulatory site influences the affinities of the intra- and extracellular transport sites for Na+ and Ca2 by DiPolo, Reinaldo, Beaugé, Luis

“…In squid axons, intracellular Mg2+ reduces the activity of the Na+/Ca2+ exchanger by competing with Ca2+ i for its regulatory site. The state of the Ca…”
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In the squid axon Na+/Ca2+ exchanger the state of the Cai-regulatory site influences the affinities of the intra- and extracellular transport sites for Na+ and Ca2 by DiPolo, Reinaldo, Beaugé, Luis

“…In squid axons, intracellular Mg 2+ reduces the activity of the Na + /Ca 2+ exchanger by competing with for its regulatory site. The state of the Ca i…”
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Metabolic regulation of the squid nerve Na +/Ca 2+ exchanger: Recent kinetic, biochemical and structural developments by Berberián, Graciela, Podjarny, Alberto, DiPolo, Reinaldo, Beaugé, Luis

“…The Na +/Ca 2+ exchangers are structural membrane proteins, essential for the extrusion of Ca 2+ from most animal cells. Apart from the transport sites, they…”
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Metabolic regulation of the squid nerve Na(+)/Ca (2+) exchanger: recent developments by Beaugé, Luis, Dipolo, Reinaldo, Bollo, Mariana, Cousido, Alexandra, Berberián, Graciela, Podjarny, Alberto

“…In squid nerves, MgATP modulation of the Na(+)/Ca(2+) exchanger requires the presence of a cytosolic protein which becomes phosphorylated during the process…”
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Metabolic regulation of the squid nerve Na⁺/Ca²⁺ exchanger: recent kinetic, biochemical and structural developments by Berberián, Graciela, Podjarny, Alberto, DiPolo, Reinaldo, Beaugé, Luis

“…The Na⁺/Ca²⁺ exchangers are structural membrane proteins, essential for the extrusion of Ca²⁺ from most animal cells. Apart from the transport sites, they have…”
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The Squid Axon Na+/Ca2+ Exchanger Shows Ping Pong Kinetics only when the Cai-regulatory Site is Saturated by Beaugé, Luis, DiPolo, Reinaldo

“…In a previous work we demonstrated that, in dialyzed squid axons, an impairment of the Ca 2+ i -regulatory site affected the apparent affinities for external…”
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Dual effect of Nai+ on Ca2+ influx through the Na+/Ca2+ exchanger in dialyzed squid axons. Experimental data confirming the validity of the squid axon kinetic model by Beaugé, Luis, DiPolo, Reinaldo

“…We propose a steady-state kinetic model for the squid Na(+)/Ca(2+) exchanger that differs from other current models of regulation in that it takes into…”
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External Sodium Affects SOCE Activation In Mouse FDB Muscle Fibers by Bolaños, Pura, Guillen, Alis, DiPolo, Reinaldo, Caputo, Carlo

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Some Biochemical Properties of the Upregulation of the Squid Nerve Na + /Ca 2+ Exchanger by MgATP and Phosphoarginine by BERBERIÁN, GRACIELA, DiPOLO, REINALDO, BEAUGÉ, LUIS

“…In squid nerve MgATP upregulation of Na + /Ca 2+ exchange requires a soluble cytosolic regulatory protein (SCRP) of about 13 kDa; phosphoarginine (PA)…”
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