Search Results - "DiMeo, Susan V"

Synthesis and Evaluation of Indenopyrazoles as Cyclin-Dependent Kinase Inhibitors. 3. Structure Activity Relationships at C3 by Yue, Eddy W, Higley, C. Anne, DiMeo, Susan V, Carini, David J, Nugiel, David A, Benware, Carrie, Benfield, Pamela A, Burton, Catherine R, Cox, Sarah, Grafstrom, Robert H, Sharp, Diane M, Sisk, Lisa M, Boylan, John F, Muckelbauer, Jodi K, Smallwood, Angela M, Chen, Haiying, Chang, Chong-Hwan, Seitz, Steven P, Trainor, George L

“…The identification of indeno[1,2-c]pyrazol-4-ones as inhibitors of cyclin-dependent kinases (CDKs) has led to the discovery of a series of novel and potent…”
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Synthesis and evaluation of indenopyrazoles as cyclin-dependent kinase inhibitors. Part 4: Heterocycles at C3 by Yue, Eddy W., DiMeo, Susan V., Higley, C.Anne, Markwalder, Jay A., Burton, Catherine R., Benfield, Pamela A., Grafstrom, Robert H., Cox, Sarah, Muckelbauer, Jodi K., Smallwood, Angela M., Chen, Haiying, Chang, Chong-Hwan, Trainor, George L., Seitz, Steven P.

“…New indeno[1,2- c]pyrazol-4-one cyclin dependent kinase inhibitors have been disclosed. The most promising compounds are nanomolar enzyme inhibitors with…”
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Development of a Scalable Synthesis toward a KRAS G12C Inhibitor Building Block Bearing an All-Carbon Quaternary Stereocenter, Part 2: Asymmetric Synthesis via Shi Epoxidation by Tan, Zhulin, Ju, Xuan, Wu, Hao, Dong, Weitong, Leung, Joyce C., Hou, Xiaowen, Lee, Heewon, Granger, Alice, Paolillo, Joshua M., DiMeo, Susan V., Chen, Chengsheng, Wu, Linglin, Lorenz, Jon C., Sarvestani, Max, Buono, Frederic, Frutos, Rogelio, Tampone, Thomas G., Huang, Xiaojun, Zhang, Gulin, Wang, Yuwen, Spinelli, Earl, Lei, Zhen, Song, Jinhua J.

“…The development of a scalable asymmetric synthesis of KRAS G12C inhibitor building block 1 is described. The all-carbon quaternary stereocenter was installed…”
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Development of a Scalable Synthesis toward a KRAS G12C Inhibitor Building Block Bearing an All-Carbon Quaternary Stereocenter, Part 1: From Discovery Route to Kilogram-Scale Production by Leung, Joyce C., Xu, Yibo, Radomkit, Suttipol, Lee, Jaehee, Kim, Wan Shin, Reeves, Jonathan T., Dong, Weitong, Jang, Hwanjong, Hou, Xiaowen, Lorenz, Jon C., Shao, Xiaole, Byrne, Denis, Johnson, Joe, Brundage, Anthony, Valentin, Clement, Beyer, Phouvieng, DiMeo, Susan V., Qu, Bo, Li, Ruoshi, Sarvestani, Max, Song, Jinhua J.

“…Synthesis of molecules containing all-carbon quaternary stereocenters has been a longstanding challenge in organic chemistry. In one of our discovery oncology…”
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