Search Results - "DiMeglio, Linda A"

COVID-19 and Type 1 Diabetes: Addressing Concerns and Maintaining Control by DiMeglio, Linda A.

“…The worldwide outbreak of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been an unprecedented pandemic. Early on, even as the signs and…”
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100 years of insulin: celebrating the past, present and future of diabetes therapy by Sims, Emily K., Carr, Alice L. J., Oram, Richard A., DiMeglio, Linda A., Evans-Molina, Carmella

“…The year 2021 marks the centennial of Banting and Best’s landmark description of the discovery of insulin. This discovery and insulin’s rapid clinical…”
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Current state of type 1 diabetes treatment in the U.S.: updated data from the T1D Exchange clinic registry by Miller, Kellee M, Foster, Nicole C, Beck, Roy W, Bergenstal, Richard M, DuBose, Stephanie N, DiMeglio, Linda A, Maahs, David M, Tamborlane, William V

“…To examine the overall state of metabolic control and current use of advanced diabetes technologies in the U.S., we report recent data collected on individuals…”
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Diagnosis and Management of Osteopetrosis: Consensus Guidelines From the Osteopetrosis Working Group by Wu, Calvin C, Econs, Michael J, DiMeglio, Linda A, Insogna, Karl L, Levine, Michael A, Orchard, Paul J, Miller, Weston P, Petryk, Anna, Rush, Eric T, Shoback, Dolores M, Ward, Leanne M, Polgreen, Lynda E

“…Abstract Background Osteopetrosis encompasses a group of rare metabolic bone diseases characterized by impaired osteoclast activity or development, resulting…”
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Racial Differences in the Relationship of Glucose Concentrations and Hemoglobin A1c Levels by Bergenstal, Richard M, Gal, Robin L, Connor, Crystal G, Gubitosi-Klug, Rose, Kruger, Davida, Olson, Beth A, Willi, Steven M, Aleppo, Grazia, Weinstock, Ruth S, Wood, Jamie, Rickels, Michael, DiMeglio, Linda A, Bethin, Kathleen E, Marcovina, Santica, Tassopoulos, Andreana, Lee, Sooji, Massaro, Elaine, Bzdick, Suzan, Ichihara, Brian, Markmann, Eileen, McGuigan, Paul, Woerner, Stephanie, Ecker, Michelle, Beck, Roy W

“…Debate exists as to whether the higher hemoglobin A1c (HbA1c) levels observed in black persons than in white persons are due to worse glycemic control or…”
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Prevalence of detectable C-Peptide according to age at diagnosis and duration of type 1 diabetes by Davis, Asa K, DuBose, Stephanie N, Haller, Michael J, Miller, Kellee M, DiMeglio, Linda A, Bethin, Kathleen E, Goland, Robin S, Greenberg, Ellen M, Liljenquist, David R, Ahmann, Andrew J, Marcovina, Santica M, Peters, Anne L, Beck, Roy W, Greenbaum, Carla J

“…It is generally accepted that complete β-cell destruction eventually occurs in individuals with type 1 diabetes, which has implications for treatment…”
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Co-stimulation modulation with abatacept in patients with recent-onset type 1 diabetes: a randomised, double-blind, placebo-controlled trial by Orban, Tihamer, MD, Bundy, Brian, PhD, Becker, Dorothy J, Prof, DiMeglio, Linda A, MD, Gitelman, Stephen E, Prof, Goland, Robin, Prof, Gottlieb, Peter A, Prof, Greenbaum, Carla J, MD, Marks, Jennifer B, Prof, Monzavi, Roshanak, MD, Moran, Antoinette, Prof, Raskin, Philip, Prof, Rodriguez, Henry, Prof, Russell, William E, Prof, Schatz, Desmond, Prof, Wherrett, Diane, MD, Wilson, Darrell M, Prof, Krischer, Jeffrey P, Prof, Skyler, Jay S, Dr, Prof

“…Summary Background The immunopathogenesis of type 1 diabetes mellitus is associated with T-cell autoimmunity. To be fully active, immune T cells need a…”
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Interleukin-1 antagonism in type 1 diabetes of recent onset: two multicentre, randomised, double-blind, placebo-controlled trials by Moran, Antoinette, Prof, Bundy, Brian, PhD, Becker, Dorothy J, Prof, DiMeglio, Linda A, MD, Gitelman, Stephen E, Prof, Goland, Robin, Prof, Greenbaum, Carla J, MD, Herold, Kevan C, Prof, Marks, Jennifer B, Prof, Raskin, Philip, Prof, Sanda, Srinath, MD, Schatz, Desmond, Prof, Wherrett, Diane K, MD, Wilson, Darrell M, Prof, Krischer, Jeffrey P, Prof, Skyler, Jay S, Prof, Pickersgill, Linda, MD, de Koning, Eelco, Prof, Ziegler, Anette-G, Prof, Böehm, Bernhard, Prof, Badenhoop, Klaus, Prof, Schloot, Nanette, MD, Bak, Jens Friis, MD, Pozzilli, Paolo, Prof, Mauricio, Didac, MD, Donath, Marc Y, Prof, Castaño, Luis, Prof, Wägner, Ana, MD, Lervang, Hans Henrik, MD, Perrild, Hans, MD, Mandrup-Poulsen, Thomas, Prof

“…Summary Background Innate immunity contributes to the pathogenesis of autoimmune diseases, such as type 1 diabetes, but until now no randomised, controlled…”
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Global Consensus Recommendations on Prevention and Management of Nutritional Rickets by Munns, Craig F, Shaw, Nick, Kiely, Mairead, Specker, Bonny L, Thacher, Tom D, Ozono, Keiichi, Michigami, Toshimi, Tiosano, Dov, Mughal, M Zulf, Mäkitie, Outi, Ramos-Abad, Lorna, Ward, Leanne, DiMeglio, Linda A, Atapattu, Navoda, Cassinelli, Hamilton, Braegger, Christian, Pettifor, John M, Seth, Anju, Idris, Hafsatu Wasagu, Bhatia, Vijayalakshmi, Fu, Junfen, Goldberg, Gail, Sävendahl, Lars, Khadgawat, Rajesh, Pludowski, Pawel, Maddock, Jane, Hyppönen, Elina, Oduwole, Abiola, Frew, Emma, Aguiar, Magda, Tulchinsky, Ted, Butler, Gary, Högler, Wolfgang

“…Vitamin D and calcium deficiencies are common worldwide, causing nutritional rickets and osteomalacia, which have a major impact on health, growth, and…”
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Antigen-based therapy with glutamic acid decarboxylase (GAD) vaccine in patients with recent-onset type 1 diabetes: a randomised double-blind trial by Wherrett, Diane K, MD, Bundy, Brian, PhD, Becker, Dorothy J, Prof, DiMeglio, Linda A, MD, Gitelman, Stephen E, Prof, Goland, Robin, Prof, Gottlieb, Peter A, Prof, Greenbaum, Carla J, MD, Herold, Kevan C, Prof, Marks, Jennifer B, Prof, Monzavi, Roshanak, MD, Moran, Antoinette, Prof, Orban, Tihamer, MD, Palmer, Jerry P, MD, Raskin, Philip, Prof, Rodriguez, Henry, Prof, Schatz, Desmond, Prof, Wilson, Darrell M, Prof, Krischer, Jeffrey P, Prof, Skyler, Jay S, Dr, Prof

“…Summary Background Glutamic acid decarboxylase (GAD) is a major target of the autoimmune response that occurs in type 1 diabetes mellitus. In animal models of…”
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Cause or effect? A review of clinical data demonstrating beta cell dysfunction prior to the clinical onset of type 1 diabetes by Sims, Emily K., DiMeglio, Linda A.

“…Limited successes of conventional approaches to type 1 diabetes (T1D) prevention and treatment have highlighted the need for improved understanding of risk…”
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Type 1 diabetes by DiMeglio, Linda A, Evans-Molina, Carmella, Oram, Richard A

“…Type 1 diabetes is a chronic autoimmune disease characterised by insulin deficiency and resultant hyperglycaemia. Knowledge of type 1 diabetes has rapidly…”
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Evaluating the effect of prebiotics on the gut microbiome profile and β cell function in youth with newly diagnosed type 1 diabetes: protocol of a pilot randomized controlled trial by Ismail, Heba M, Spall, Maria, Evans-Molina, Carmella, DiMeglio, Linda A

“…Data show that disturbances in the gut microbiota play a role in glucose homeostasis, type 1 diabetes (T1D) risk and progression. The prebiotic high amylose…”
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Growth differentiation factor 15 (GDF15) elevation in children with newly diagnosed cancer by Runco, Daniel V, DiMeglio, Linda A, Vanderpool, Charles P, Han, Yan, Daggy, Joanne, Kelley, Mary M, Mikesell, Raya, Zimmers, Teresa A

“…Growth differentiation factor 15 (GDF15), an inflammatory marker and mediator of adult cancer cachexia, remains largely unexplored in children. GDF15 increases…”
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Targeting of memory T cells with alefacept in new-onset type 1 diabetes (T1DAL study): 12 month results of a randomised, double-blind, placebo-controlled phase 2 trial by Rigby, Mark R, Prof, DiMeglio, Linda A, Prof, Rendell, Marc S, MD, Felner, Eric I, Prof, Dostou, Jean M, Prof, Gitelman, Stephen E, Prof, Patel, Chetanbabu M, MD, Griffin, Kurt J, Prof, Tsalikian, Eva, Prof, Gottlieb, Peter A, Prof, Greenbaum, Carla J, MD, Sherry, Nicole A, MD, Moore, Wayne V, MD, Monzavi, Roshanak, MD, Willi, Steven M, MD, Raskin, Philip, Prof, Moran, Antoinette, Prof, Russell, William E, Prof, Pinckney, Ashley, MS, Keyes-Elstein, Lynette, DrPH, Howell, Michael, PhD, Aggarwal, Sudeepta, PhD, Lim, Noha, PhD, Phippard, Deborah, PhD, Nepom, Gerald T, MD, McNamara, James, MD, Ehlers, Mario R, MBChB

“…Summary Background Type 1 diabetes results from autoimmune targeting of the pancreatic β cells, likely mediated by effector memory T (Tem) cells. CD2, a T cell…”
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In Vitro Hyperglycemia or a Diabetic Intrauterine Environment Reduces Neonatal Endothelial Colony-Forming Cell Numbers and Function by INGRAM, David A, LIEN, Izlin Z, MEAD, Laura E, ESTES, Myka, PRATER, Daniel N, DERR-YELLIN, Ethel, DIMEGLIO, Linda A, HANELINE, Laura S

“…In Vitro Hyperglycemia or a Diabetic Intrauterine Environment Reduces Neonatal Endothelial Colony-Forming Cell Numbers and Function David A. Ingram 1 , 2 ,…”
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Analysis of serum Hsp90 as a potential biomarker of β cell autoimmunity in type 1 diabetes by Ocaña, Gail J, Sims, Emily K, Watkins, Renecia A, Ragg, Susanne, Mather, Kieren J, Oram, Richard A, Mirmira, Raghavendra G, DiMeglio, Linda A, Blum, Janice S, Evans-Molina, Carmella

“…Heat shock protein 90 (Hsp90) is a protein chaperone that is upregulated and released from pancreatic β cells under pro-inflammatory conditions. We…”
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Incidence and Characteristics of Pseudoprecocious Puberty Because of Severe Primary Hypothyroidism by Cabrera, Susanne M., MD, DiMeglio, Linda A., MD, MPH, Eugster, Erica A., MD

“…Severe primary hypothyroidism is a presumed rare cause of pseudoprecocious puberty (PsPP). Here, we report a 24% incidence of PsPP among 33 children with…”
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Vitamin D Status and Calcium Metabolism in Adolescent Black and White Girls on a Range of Controlled Calcium Intakes by Weaver, Connie M., McCabe, Linda D., McCabe, George P., Braun, Michelle, Martin, Berdine R., DiMeglio, Linda A., Peacock, Munro

“…Background: There are limited data in adolescents on racial differences in relationships between dietary calcium intake, absorption, and retention and serum…”
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Safety and prescribing recommendations for verapamil in newly diagnosed pediatric type 1 diabetes (T1D): The CLVer experience by Ekhlaspour, Laya, Buckingham, Bruce, Bauza, Colleen, Clements, Mark, Forlenza, Gregory P., Neyman, Anna, Norlander, Lisa, Schamberger, Marcus, Sherr, Jennifer L., Bailey, Ryan, Beck, Roy W., Kollman, Craig, Beasley, Shannon, Cobry, Erin, DiMeglio, Linda A., Paprocki, Emily, Van Name, Michelle, Moran, Antoinette

“…To report the safety and side effects associated with taking verapamil for beta-cell preservation in children with newly-diagnosed T1D. Eighty-eight…”
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