Search Results - "DiJoseph, J"

Therapeutic potential of CD22-specific antibody-targeted chemotherapy using inotuzumab ozogamicin (CMC-544) for the treatment of acute lymphoblastic leukemia by DIJOSEPH, J. F, DOUGHER, M. M, ARMELLINO, D. C, EVANS, D. Y, DAMLE, N. K

“…CMC-544 (inotuzumab ozogamicin) is a CD22-specific cytotoxic immunoconjugate of calicheamicin intended for the treatment of B-lymphoid malignancies. This…”
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The oncofetal protein, 5T4, is a suitable target for antibody-guided anti-cancer chemotherapy with calicheamicin by BOGHAERT, E. R, SRIDHARAN, L, DOUGHER, M, DIJOSEPH, J. F, DAMLE, N. K, KHANDKE, K. M, ARMELLINO, D, RYAN, M. G, MYERS, K, HARROP, R, KUNZ, A, HAMANN, P. R, MARQUETTE, K

“…The oncofetal protein, 5T4, is a tumor-associated protein displayed on the cell membrane of various carcinomas. This molecule is a promising target for…”
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Synthesis and SAR of bicyclic heteroaryl hydroxamic acid MMP and TACE inhibitors by Zask, A., Gu, Y., Albright, J.D., Du, X., Hogan, M., Levin, J.I., Chen, J.M., Killar, L.M., Sung, A., DiJoseph, J.F., Sharr, M.A., Roth, C.E., Skala, S., Jin, G., Cowling, R., Mohler, K.M., Barone, D., Black, R., March, C., Skotnicki, J.S.

“…Potent and selective bicyclic heteroaryl hydroxamic acid MMP and TACE inhibitors were synthesized by a novel convergent route. Selectivity and efficacy versus…”
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The discovery of anthranilic acid-based MMP inhibitors. Part 2: SAR of the 5-position and P1(1) groups by Levin, J I, Chen, J, Du, M, Hogan, M, Kincaid, S, Nelson, F C, Venkatesan, A M, Wehr, T, Zask, A, DiJoseph, J, Killar, L M, Skala, S, Sung, A, Sharr, M, Roth, C, Jin, G, Cowling, R, Mohler, K M, Black, R A, March, C J, Skotnicki, J S

“…A novel series of anthranilic acid-based inhibitors of MMP-1, MMP-9, MMP-13, and TACE was prepared and evaluated. Selective inhibitors of MMP-9, MMP-13, and…”
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The discovery of anthranilic acid-based mmp inhibitors. Part 3: incorporation of basic amines by Levin, J.I, Chen, J.M, Du, M.T, Nelson, F.C, Wehr, T, DiJoseph, J.F, Killar, L.M, Skala, S, Sung, A, Sharr, M.A, Roth, C.E, Jin, G, Cowling, R, Di, L, Sherman, M, Xu, Z.B, March, C.J, Mohler, K.M, Black, R.A, Skotnicki, J.S

“…Anthranilic acid derivatives bearing basic amines were prepared and evaluated in vitro and in vivo as inhibitors of MMP-1, MMP-9, MMP-13, and TACE. Piperazine…”
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The effect of rapamycin on kidney function in the Sprague-Dawley rat by DiJoseph, J F, Sharma, R N, Chang, J Y

“…The effects of rapamycin (RAPA) on kidney function and histology were investigated in the Sprague-Dawley rat and compared with cyclosporine. Drugs were…”
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Antibody-targeted chemotherapy of B-cell lymphoma using calicheamicin conjugated to murine or humanized antibody against CD22 by DIJOSEPH, John F, POPPLEWELL, Andrew, ZINKEWICH-PEOTTI, Karen, STEPHENS, Sue, WEIR, Neil, DAMLE, Nitin K, TICKLE, Simon, LADYMAN, Heather, LAWSON, Alastair, KUNZ, Arthur, KHANDKE, Kiran, ARMELLINO, Douglas C, BOGHAERT, Erwin R, HAMANN, Philip R

“…Antibody-targeted chemotherapy with immunoconjugates of calicheamicin is a clinically validated strategy in cancer therapy. This study describes the selection…”
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Therapeutic blood levels of sirolimus (rapamycin) in the allografted rat by DIJOSEPH, J. F, FLUHLER, E, ARMSRONG, J, SHARR, M, SEHGAL, S. N

“…A study was conducted to determine the relationship among oral dose, trough whole blood levels, graft survival, and side effects in sirolimus-treated…”
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The synthesis and biological activity of a novel series of diazepine MMP inhibitors by Levin, Jeremy I., DiJoseph, John F., Killar, Loran M., Sung, Amy, Walter, Thomas, Sharr, Michele A., Roth, Catherine E., Skotnicki, Jerauld S., Albright, J.Donald

“…A novel series of diazepine-based hydroxamic acid inhibitors of MMP-1, MMP-9, and MMP-13 were prepared and evaluated both in vitro and in vivo. A novel series…”
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Malonyl α-mercaptoketones and α-mercaptoalcohols, a new class of matrix metalloproteinase inhibitors by Campbell, David A., Xiao, Xiao-Yi, Harris, David, Ida, Satoru, Mortezaei, Reza, Ngu, Khehyong, Shi, Lihong, Tien, David, Wang, Yongwen, Navre, Marc, Patel, Dinesh V., Sharr, Michele A., DiJoseph, John F., Killar, Loran M., Leone, Christina L., Levin, Jeremy I., Skotnicki, Jerauld S.

“…A novel series of matrix metalloproteinase (MMP) inhibitors is described. Incorporation of a terminal α-mercaptoketone or α-mercaptoalcohol in the zinc binding…”
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The asymmetric synthesis and in vitro characterization of succinyl mercaptoalcohol and mercaptoketone inhibitors of matrix metalloproteinases by Levin, Jeremy I., DiJoseph, John F., Killar, Loran M., Sharr, Michele A., Skotnicki, Jerauld S., Patel, Dinesh V., Xiao, Xiao-Yi, Shi, Lihong, Navre, Marc, Campbell, David A.

“…A series of succinyl based mercaptoketones and diastereomeric mercaptoalcohols were prepared and evaluated in vitro as inhibitors of the matrix…”
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The discovery of anthranilic acid-based MMP inhibitors. Part 2 : SAR of the 5-position and P11 groups by LEVIN, J. I, CHEN, J, KILLAR, L. M, SKALA, S, SUNG, A, SHARR, M, ROTH, C, JIN, G, COWLING, R, MOHLER, K. M, BLACK, R. A, MARCH, C. J, DU, M, SKOTNICKI, J. S, HOGAN, M, KINCAID, S, NELSON, F. C, VENKATESAN, A. M, WEHR, T, ZASK, A, DIJOSEPH, J

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The discovery of anthranilic acid-based MMP inhibitors. Part 1: SAR of the 3-position by LEVIN, Jeremy I, DU, Mila T, GUIXIAN JIN, COWLING, Rebecca, SKOTNICKI, Jerauld S, DIJOSEPH, John F, KILLAR, Loran M, SUNG, Amy, WALTER, Thomas, SHARR, Michele A, ROTH, Catherine E, MOY, Franklin J, POWERS, Robert

“…A novel series of anthranilic acid-based inhibitors of MMP-1, MMP-9, and MMP-13 was prepared and evaluated both in vitro and in vivo. The most potent compound,…”
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Renal effects of rapamycin in the spontaneously hypertensive rat by DiJoseph, J F, Mihatsch, M J, Sehgal, S N

“…The effects of rapamycin (RAPA), administered at therapeutic doses, were investigated in the spontaneously hypertensive rat (SHR). Additionally, the…”
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Influence of rat strain on rapamycin's kidney effects by DiJoseph, J F, Mihatsch, M J, Sehgal, S N

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Gastric antisecretory and antiulcer effects of WHR1582A, a compound exerting alpha-2 adrenoceptor agonist activity by DiJoseph, J F, Eash, J R, Mir, G N

“…The gastric antisecretory and antiulcer effects of a novel compound, [1-(2,-dimethylphenyl)-3-isobutoxyamidinourea]hydrochloride (WHR1582A), are described…”
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Heteroaryl and cycloalkyl sulfonamide hydroxamic acid inhibitors of matrix metalloproteinases by LEVIN, Jeremy I, YANSONG GU, COSMI, Scott, HSIAO, Chu-Lai, EDRIS, Wade, WILHELM, James, KILLAR, Loran M, SKOTNICKI, Jerauld S, NELSON, Frances C, ZASK, Arie, DIJOSEPH, John F, SHARR, Michele A, SUNG, Amy, GUIXIAN JIN, COWLING, Rebecca, CHANDA, Pranab

“…Heteroaryl and cycloalkyl sulfonamide-hydroxamic acid MMP inhibitors were investigated. Of these, the pyridyl analogue 2 is the most potent and selective…”
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Activated aluminum complex derived from solubilized antacids exhibits enhanced cytoprotective activity in the rat by DiJoseph, J F, Borella, L E, Mir, G N

“…Removing the buffering capacity of aluminum-containing antacids by acidification greatly increased their cytoprotective activity over the parent antacid…”
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Dialysis tubing implant assay in the rat: A novel in vivo method for identifying inhibitors of matrix metalloproteinases by DiJoseph, John F., Sharr, Michele A.

“…A novel model to assess the in vivo bioactivity of matrix metalloproteinase (MMP) inhibitors is described. A solution containing the target enzyme, either…”
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Kidney dysfunction in the arthritic rat by Dijoseph, J F, Walter, T L, Hartman, D A, Carlson, R P

“…Kidney function and histopathology were investigated in the adjuvant-induced arthritic rat. Rats injected with Mycobacterium butyricum exhibited symptoms of…”
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