Search Results - "DiGregorio, A"

Nanoscale Distribution of Presynaptic Ca2+ Channels and Its Impact on Vesicular Release during Development by Nakamura, Yukihiro, Harada, Harumi, Kamasawa, Naomi, Matsui, Ko, Rothman, Jason S., Shigemoto, Ryuichi, Silver, R. Angus, DiGregorio, David A., Takahashi, Tomoyuki

“…Synaptic efficacy and precision are influenced by the coupling of voltage-gated Ca2+ channels (VGCCs) to vesicles. But because the topography of VGCCs and…”
Get full text

Distinct Nanoscale Calcium Channel and Synaptic Vesicle Topographies Contribute to the Diversity of Synaptic Function by Rebola, Nelson, Reva, Maria, Kirizs, Tekla, Szoboszlay, Miklos, Lőrincz, Andrea, Moneron, Gael, Nusser, Zoltan, DiGregorio, David A.

“…The nanoscale topographical arrangement of voltage-gated calcium channels (VGCC) and synaptic vesicles (SVs) determines synaptic strength and plasticity, but…”
Get full text

Stability, affinity, and chromatic variants of the glutamate sensor iGluSnFR by Marvin, Jonathan S., Scholl, Benjamin, Wilson, Daniel E., Podgorski, Kaspar, Kazemipour, Abbas, Müller, Johannes Alexander, Schoch, Susanne, Quiroz, Francisco José Urra, Rebola, Nelson, Bao, Huan, Little, Justin P., Tkachuk, Ariana N., Cai, Edward, Hantman, Adam W., Wang, Samuel S.-H., DePiero, Victor J., Borghuis, Bart G., Chapman, Edwin R., Dietrich, Dirk, DiGregorio, David A., Fitzpatrick, David, Looger, Loren L.

“…Single-wavelength fluorescent reporters allow visualization of specific neurotransmitters with high spatial and temporal resolution. We report variants of…”
Get full text

Synaptic basis of a sub-second representation of time in a neural circuit model by Barri, A., Wiechert, M. T., Jazayeri, M., DiGregorio, D. A.

“…Temporal sequences of neural activity are essential for driving well-timed behaviors, but the underlying cellular and circuit mechanisms remain elusive. We…”
Get full text

Thin Dendrites of Cerebellar Interneurons Confer Sublinear Synaptic Integration and a Gradient of Short-Term Plasticity by Abrahamsson, Therese, Cathala, Laurence, Matsui, Ko, Shigemoto, Ryuichi, DiGregorio, David A.

“…Interneurons are critical for neuronal circuit function, but how their dendritic morphologies and membrane properties influence information flow within…”
Get full text

A first-passage approach to diffusion-influenced reversible binding and its insights into nanoscale signaling at the presynapse by Reva, Maria, DiGregorio, David A., Grebenkov, Denis S.

“…Synaptic transmission between neurons is governed by a cascade of stochastic calcium ion reaction–diffusion events within nerve terminals leading to vesicular…”
Get full text

Synaptic diversity enables temporal coding of coincident multisensory inputs in single neurons by Chabrol, François P, Arenz, Alexander, Wiechert, Martin T, Margrie, Troy W, DiGregorio, David A

“…Processing multiple sensory modalities is critical for executing complex behaviors. This study finds that single cerebellar granule cells integrate inputs from…”
Get full text

Variations in Ca2+ Influx Can Alter Chelator-Based Estimates of Ca2+ Channel-Synaptic Vesicle Coupling Distance by Nakamura, Yukihiro, Reva, Maria, DiGregorio, David A

“…The timing and probability of synaptic vesicle fusion from presynaptic terminals is governed by the distance between voltage-gated Ca 2+ channels (VGCCs) and…”
Get full text

A Role for Synaptic Input Distribution in a Dendritic Computation of Motion Direction in the Retina by Vlasits, Anna L., Morrie, Ryan D., Tran-Van-Minh, Alexandra, Bleckert, Adam, Gainer, Christian F., DiGregorio, David A., Feller, Marla B.

“…The starburst amacrine cell in the mouse retina presents an opportunity to examine the precise role of sensory input location on neuronal computations. Using…”
Get full text

Underpinning heterogeneity in synaptic transmission by presynaptic ensembles of distinct morphological modules by Fekete, Adam, Nakamura, Yukihiro, Yang, Yi-Mei, Herlitze, Stefan, Mark, Melanie D., DiGregorio, David A., Wang, Lu-Yang

“…Synaptic heterogeneity is widely observed but its underpinnings remain elusive. We addressed this issue using mature calyx of Held synapses whose numbers of…”
Get full text

Ca2+ channel to synaptic vesicle distance accounts for the readily releasable pool kinetics at a functionally mature auditory synapse by Chen, Zuxin, Das, Brati, Nakamura, Yukihiro, DiGregorio, David A, Young, Jr, Samuel M

“…Precise regulation of synaptic vesicle (SV) release at the calyx of Held is critical for auditory processing. At the prehearing calyx of Held, synchronous and…”
Get full text

Demonstration that sublinear dendrites enable linearly non-separable computations by Cazé, Romain D., Tran-Van-Minh, Alexandra, Gutkin, Boris S., DiGregorio, David A.

“…Theory predicts that nonlinear summation of synaptic potentials within dendrites allows neurons to perform linearly non-separable computations (LNSCs). Using…”
Get full text

Holographic photolysis of caged neurotransmitters by Emiliani, Valentina, Lutz, Christoph, Otis, Thomas S, DeSars, Vincent, Charpak, Serge, DiGregorio, David A

“…Holographic illumination allows the production of complex, user-defined, two-dimensional illumination patterns. Used to manipulate light-sensitive molecules in…”
Get full text

Feed-forward recruitment of electrical synapses enhances synchronous spiking in the mouse cerebellar cortex by Hoehne, Andreas, McFadden, Maureen H, DiGregorio, David A

“…In the cerebellar cortex, molecular layer interneurons use chemical and electrical synapses to form subnetworks that fine-tune the spiking output of the…”
Get full text

Contribution of sublinear and supralinear dendritic integration to neuronal computations by Tran-Van-Minh, Alexandra, Cazé, Romain D, Abrahamsson, Therése, Cathala, Laurence, Gutkin, Boris S, DiGregorio, David A

“…Nonlinear dendritic integration is thought to increase the computational ability of neurons. Most studies focus on how supralinear summation of excitatory…”
Get full text

A portable miniaturized laser heterodyne radiometer (mini-LHR) for remote measurements of column CH4 and CO2 by Wilson, E. L., DiGregorio, A. J., Villanueva, G., Grunberg, C. E., Souders, Z., Miletti, K. M., Menendez, A., Grunberg, M. H., Floyd, M. A. M., Bleacher, J. E., Euskirchen, E. S., Edgar, C., Caldwell, B. J., Shiro, B., Binsted, K.

“…We present the design of a portable version of our miniaturized laser heterodyne radiometer (mini-LHR) that simultaneously measures methane (CH 4 ) and carbon…”
Get full text

Developmental emergence of two-stage nonlinear synaptic integration in cerebellar interneurons by Biane, Celia, Rückerl, Florian, Abrahamsson, Therese, Saint-Cloment, Cécile, Mariani, Jean, Shigemoto, Ryuichi, DiGregorio, David A, Sherrard, Rachel M, Cathala, Laurence

“…Synaptic transmission, connectivity, and dendritic morphology mature in parallel during brain development and are often disrupted in neurodevelopmental…”
Get full text

Modulation of Glutamate Mobility Reveals the Mechanism Underlying Slow-Rising AMPAR EPSCs and the Diffusion Coefficient in the Synaptic Cleft by Nielsen, Thomas A., DiGregorio, David A., Silver, R.Angus

“…Fast- and slow-rising AMPA receptor-mediated EPSCs occur at central synapses. Fast-rising EPSCs are thought to be mediated by rapid local release of glutamate…”
Get full text

Two-photon compatibility and single-voxel, single-trial detection of subthreshold neuronal activity by a two-component optical voltage sensor by Fink, Ann E, Bender, Kevin J, Trussell, Laurence O, Otis, Thomas S, DiGregorio, David A

“…Minimally invasive measurements of neuronal activity are essential for understanding how signal processing is performed by neuronal networks. While optical…”
Get full text

Spillover of Glutamate onto Synaptic AMPA Receptors Enhances Fast Transmission at a Cerebellar Synapse by DiGregorio, David A., Nusser, Zoltan, Silver, R.Angus

“…Diffusion of glutamate from the synaptic cleft can activate high-affinity receptors, but is not thought to contribute to fast AMPA receptor-mediated…”
Get full text