Search Results - "DiFrancesco, D."

Funny channels in the control of cardiac rhythm and mode of action of selective blockers by DiFrancesco, Dario

“…“Funny” (f) channels underlie the cardiac “pacemaker”If current, originally described as an inward current activated on hyperpolarization to the diastolic…”
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Properties of ivabradine-induced block of HCN1 and HCN4 pacemaker channels by Bucchi, A., Tognati, A., Milanesi, R., Baruscotti, M., DiFrancesco, D.

“…Ivabradine is a ‘heart rate-reducing’ agent able to slow heart rate, without complicating side-effects. Its action results from a selective and specific…”
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Cell-specific Dynamic Clamp analysis of the role of funny If current in cardiac pacemaking by Ravagli, E., Bucchi, A., Bartolucci, C., Paina, M., Baruscotti, M., DiFrancesco, D., Severi, S.

“…We used the Dynamic Clamp technique for i) comparative validation of conflicting computational models of the hyperpolarization-activated funny current, If, and…”
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Cardiac mesoangioblasts are committed, self-renewable progenitors, associated with small vessels of juvenile mouse ventricle by Galvez, B G, Sampaolesi, M, Barbuti, A, Crespi, A, Covarello, D, Brunelli, S, Dellavalle, A, Crippa, S, Balconi, G, Cuccovillo, I, Molla, F, Staszewsky, L, Latini, R, DiFrancesco, D, Cossu, G

“…Different cardiac stem/progenitor cells have been recently identified in the post-natal heart. We describe here the identification, clonal expansion and…”
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From Funny Current to HCN Channels: 20 Years of Excitation by Accili, E. A, Proenza, C, Baruscotti, M, DiFrancesco, D

“…E. A. Accili 3 , C. Proenza 3 , M. Baruscotti 1 and D. DiFrancesco 1 ,2 1 Dipartimento di Fisiologia e Biochimica Generali, Laboratorio di Fisiologia…”
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Action of the hyperpolarization-activated current (Ih) blocker ZD 7288 in hippocampal CA1 neurons by Gasparini, S, DiFrancesco, D

“…The effects of ZD 7288, a "bradycardic" agent, in young rat hippocampal slices in vitro were studied. ZD 7288 (1-1000 microM) reduced the…”
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Heart rate reduction via selective ‘funny’ channel blockers by Bucchi, Annalisa, Barbuti, Andrea, Baruscotti, Mirko, DiFrancesco, Dario

“…The ‘funny’ current, first described in cardiac pacemaker cells almost 30 years ago, is a key player in the generation of pacemaker activity and the autonomic…”
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The contribution of the 'pacemaker' current (if) to generation of spontaneous activity in rabbit sino-atrial node myocytes by DiFrancesco, D

“…1. The contribution to the diastolic depolarization of the hyperpolarization-activated current, if, relative to other components was investigated in isolated…”
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High cardiac differentiation properties are evident in induced pluripotent stem cells obtained from atrial mesenchymal cells by Meraviglia, V, Wen, J, Piacentini, L, Campostrini, G, Wang, C, Florio, M.C, Azzimato, V, Fassina, L, Langes, M, Wong, J, Miragoli, M, Gaetano, C, Pompilio, G, Barbuti, A, DiFrancesco, D, Mascalzoni, D, Pramstaller, P.P, Colombo, G.I, Chen, H.S.V, Rossini, A

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Modulation of single hyperpolarization-activated channels (i(f)) by cAMP in the rabbit sino-atrial node by DiFrancesco, D, Mangoni, M

“…1. The hyperpolarization-activated 'pacemaker' current (i(f)) was recorded in inside-out patches excised from rabbit sino-atrial (SA) node cell membranes. 2…”
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A Potassium Channel Protein Encoded by Chlorella Virus PBCV-1 by Plugge, B., Gazzarrini, S., Nelson, M., Cerana, R., van Etten, J. L., Derst, C., DiFrancesco, D., Moroni, A., Thiel, G.

“…The large chlorella virus PBCV-1, which contains double-stranded DNA (dsDNA), encodes a 94-codon open reading frame (ORF) that contains a motif resembling the…”
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Properties of the hyperpolarization-activated current in rat hippocampal CA1 pyramidal cells by Maccaferri, G, Mangoni, M, Lazzari, A, DiFrancesco, D

“…1. Voltage and current clamp recordings were performed on CA1 rat hippocampal pyramidal cells using the patch clamp technique on "in vitro" slice preparations…”
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Integrated allosteric model of voltage gating of HCN channels by Altomare, C, Bucchi, A, Camatini, E, Baruscotti, M, Viscomi, C, Moroni, A, DiFrancesco, D

“…Hyperpolarization-activated (pacemaker) channels are dually gated by negative voltage and intracellular cAMP. Kinetics of native cardiac f-channels are not…”
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The onset and autonomic regulation of cardiac pacemaker activity: relevance of the f current by DiFrancesco, D

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A model of cardiac electrical activity incorporating ionic pumps and concentration changes by Di Francesco, D., Noble, Denis

“…Equations have been developed to describe cardiac action potentials and pacemaker activity. The model takes account of extensive developments in experimental…”
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Differential control of the hyperpolarization-activated current (i(f)) by cAMP gating and phosphatase inhibition in rabbit sino-atrial node myocytes by Accili, E A, Redaelli, G, DiFrancesco, D

“…1. The actions of the phosphatase inhibitor calyculin A on the hyperpolarization-activated cardiac 'pacemaker' current (i(f)) were determined in single cells…”
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A new interpretation of the pace-maker current in calf Purkinje fibres by DiFrancesco, D

“…1. The properties of the 'pace-maker' current iK2 of Purkinje fibres are investigated to verify whether its behaviour during voltage-clamp pulses is consistent…”
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Basal responses of the L-type Ca2+ and hyperpolarization-activated currents to autonomic agonists in the rabbit sino-atrial node by Zaza, A, Robinson, R B, DiFrancesco, D

“…1. The dose dependence of the cholinergic agonist acetylcholine (ACh) and the beta-adrenergic agonist isoprenaline (Iso) were determined for the…”
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A study of the ionic nature of the pace-maker current in calf Purkinje fibres by DiFrancesco, D

“…1. Properties of the pace-maker current (if) in Purkinje fibres were studied in the presence of Ba, which by partially blocking the iK1 channel reduces K…”
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Activation of f-channels by cAMP analogues in macropatches from rabbit sino-atrial node myocytes by Bois, P., Renaudon, B., Baruscotti, M., Lenfant, J., DiFrancesco, D.

“…1. The action of the two diastereometric phosphorothioate derivatives of cAMP, Rp-cAMPs and Sp-cAMPs, was investigated on hyperpolarization-activated…”
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