Search Results - "DiFrancesco, Benjamin R."

The TPR domain of PgaA is a multifunctional scaffold that binds PNAG and modulates PgaB-dependent polymer processing by Pfoh, Roland, Subramanian, Adithya S, Huang, Jingjing, Little, Dustin J, Forman, Adam, DiFrancesco, Benjamin R, Balouchestani-Asli, Negar, Kitova, Elena N, Klassen, John S, Pomès, Régis, Nitz, Mark, Howell, P. Lynne

“…The synthesis of exopolysaccharides as biofilm matrix components by pathogens is a crucial factor for chronic infections and antibiotic resistance. Many…”
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Modification and periplasmic translocation of the biofilm exopolysaccharide poly-β-1,6-N-acetyl-D-glucosamine by Little, Dustin J., Li, Grace, Ing, Christopher, DiFrancesco, Benjamin R., Bamford, Natalie C., Robinson, Howard, Nitz, Mark, Pomès, Régis, Howell, P. Lynne

“…Poly-β-1,6-N-acetyl-D-glucosamine (PNAG) is an exopolysaccharide produced by a wide variety of medically important bacteria. Poly-glucosamine subunit B (PgaB)…”
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Small Molecule Inhibition of an Exopolysaccharide Modification Enzyme is a Viable Strategy To Block Pseudomonas aeruginosa Pel Biofilm Formation by Razvi, Erum, DiFrancesco, Benjamin R, Wasney, Gregory A, Morrison, Zachary A, Tam, John, Auger, Anick, Baker, Perrin, Alnabelseya, Noor, Rich, Jacquelyn D, Sivarajah, Piyanka, Whitfield, Gregory B, Harrison, Joe J, Melnyk, Roman A, Nitz, Mark, Howell, P Lynne

“…Biosynthesis of the Pel exopolysaccharide in Pseudomonas aeruginosa requires all seven genes of the operon. The periplasmic modification enzyme PelA contains a…”
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Discovery of a novel class of aldol-derived 1,2,3-triazoles: Potent and selective inhibitors of human cytochrome P450 19A1 (aromatase) by McNulty, James, Nair, Jerald J., Vurgun, Nesrin, DiFrancesco, Benjamin R., Brown, Carla E., Tsoi, Bernice, Crankshaw, Denis J., Holloway, Alison C.

“…The discovery of a novel five-component 1,2,3-triazole-containing pharmacophore that exhibits potent and selective inhibition of aromatase (CYP 450 19A1) is…”
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Monosaccharide inhibitors targeting carbohydrate esterase family 4 de-N-acetylases by DiFrancesco, Benjamin R., Morrison, Zachary A., Nitz, Mark

“…[Display omitted] The Carbohydrate Esterase family 4 contains virulence factors which modify peptidoglycan and biofilm-related exopolysaccharides. Despite the…”
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The Protein BpsB Is a Poly-β-1,6-N-acetyl-d-glucosamine Deacetylase Required for Biofilm Formation in Bordetella bronchiseptica by Little, Dustin J., Milek, Sonja, Bamford, Natalie C., Ganguly, Tridib, DiFrancesco, Benjamin R., Nitz, Mark, Deora, Rajendar, Howell, P. Lynne

“…Bordetella pertussis and Bordetella bronchiseptica are the causative agents of whooping cough in humans and a variety of respiratory diseases in animals,…”
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Investigation of aryl halides as ketone bioisosteres: Refinement of potent and selective inhibitors of human cytochrome P450 19A1 (aromatase) by McNulty, James, Nielsen, Alexander J., Brown, Carla E., DiFrancesco, Benjamin R., Vurgun, Nesrin, Nair, Jerald J., Crankshaw, Denis J., Holloway, Alison C.

“…Bioisosteric replacement of cyclic ketone functionality with aryl halides was investigated on a centrally-flexible, five-component 1,2,3-triazole-containing…”
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Modification and periplasmic translocation of the biofilm exopolysaccharide poly-[Beta]-1,6-N-acetyl-D-glucosamine by Little, Dustin J, Li, Grace, Ing, Christopher, DiFrancesco, Benjamin R, Bamford, Natalie C, Robinson, Howard, Nitz, Mark, Pomès, Régis, Howell, P Lynne

“…Poly-β-1,6-N-acetyl-D-glucosamine (PNAG) is an exopolysaccharide produced by a wide variety of medically important bacteria. Polyglucosamine subunit B (PgaB)…”
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