Search Results - "DiCello, Jesse J."

Endosomal signaling of delta opioid receptors is an endogenous mechanism and therapeutic target for relief from inflammatory pain by Jimenez-Vargas, Nestor N., Gong, Jing, Wisdom, Matthew J., Jensen, Dane D., Latorre, Rocco, Hegron, Alan, Teng, Shavonne, DiCello, Jesse J., Rajasekhar, Pradeep, Veldhuis, Nicholas A., Carbone, Simona E., Yu, Yang, Lopez-Lopez, Cintya, Jaramillo-Polanco, Josue, Canals, Meritxell, Reed, David E., Lomax, Alan E., Schmidt, Brian L., Leong, Kam W., Vanner, Stephen J., Halls, Michelle L., Bunnett, Nigel W., Poole, Daniel P.

“…Whether G protein-coupled receptors signal from endosomes to control important pathophysiological processes and are therapeutic targets is uncertain. We report…”
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Positive allosteric modulation of endogenous delta opioid receptor signaling in the enteric nervous system is a potential treatment for gastrointestinal motility disorders by DiCello, Jesse J, Carbone, Simona E, Saito, Ayame, Pham, Vi, Szymaszkiewicz, Agata, Gondin, Arisbel B, Alvi, Sadia, Marique, Kiliana, Shenoy, Priyank, Veldhuis, Nicholas A, Fichna, Jakub, Canals, Meritxell, Christopoulos, Arthur, Valant, Celine, Poole, Daniel P

“…Allosteric modulators (AMs) are molecules that can fine-tune signaling by G protein-coupled receptors (GPCRs). Although they are a promising therapeutic…”
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Distribution and trafficking of the μ-opioid receptor in enteric neurons of the guinea pig by Lay, Joslyn, Carbone, Simona E, DiCello, Jesse J, Bunnett, Nigel W, Canals, Meritxell, Poole, Daniel P

“…The μ-opioid receptor (MOR) is a major regulator of gastrointestinal motility and secretion and mediates opiate-induced bowel dysfunction. Although MOR is of…”
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Agonist-dependent development of delta opioid receptor tolerance in the colon by DiCello, Jesse J., Saito, Ayame, Rajasekhar, Pradeep, Sebastian, Benjamin W., McQuade, Rachel M., Gondin, Arisbel B., Veldhuis, Nicholas A., Canals, Meritxell, Carbone, Simona E., Poole, Daniel P.

“…The use of opioid analgesics is severely limited due to the development of intractable constipation, mediated through activation of mu opioid receptors (MOR)…”
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Clathrin and GRK2/3 inhibitors block δ-opioid receptor internalization in myenteric neurons and inhibit neuromuscular transmission in the mouse colon by DiCello, Jesse J, Rajasekhar, Pradeep, Eriksson, Emily M, Saito, Ayame, Gondin, Arisbel B, Veldhuis, Nicholas A, Canals, Meritxell, Carbone, Simona E, Poole, Daniel P

“…Endocytosis is a major mechanism through which cellular signaling by G protein-coupled receptors (GPCRs) is terminated. However, recent studies demonstrate…”
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INSL5 activates multiple signalling pathways and regulates GLP-1 secretion in NCI-H716 cells by Ang, Sheng Y, Evans, Bronwyn A, Poole, Daniel P, Bron, Romke, DiCello, Jesse J, Bathgate, Ross A D, Kocan, Martina, Hutchinson, Dana S, Summers, Roger J

“…Insulin-like peptide 5 (INSL5) is a newly discovered gut hormone expressed in colonic enteroendocrine L-cells but little is known about its biological…”
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Mu and Delta Opioid Receptors Are Coexpressed and Functionally Interact in the Enteric Nervous System of the Mouse Colon by DiCello, Jesse J., Carbone, Simona E., Saito, Ayame, Rajasekhar, Pradeep, Ceredig, Rhian A., Pham, Vi, Valant, Celine, Christopoulos, Arthur, Veldhuis, Nicholas A., Canals, Meritxell, Massotte, Dominique, Poole, Daniel P.

“…Functional interactions between the mu opioid receptor (MOR) and delta opioid receptor (DOR) represent a potential target for novel analgesics and may drive…”
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Mu and Delta Opioid Receptors Are Coexpressed and Functionally Interact in the Enteric Nervous System of the Mouse ColonSummary by Jesse J. DiCello, Simona E. Carbone, Ayame Saito, Pradeep Rajasekhar, Rhian A. Ceredig, Vi Pham, Celine Valant, Arthur Christopoulos, Nicholas A. Veldhuis, Meritxell Canals, Dominique Massotte, Daniel P. Poole

“…Background & Aims: Functional interactions between the mu opioid receptor (MOR) and delta opioid receptor (DOR) represent a potential target for novel…”
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